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404505
Cytokine receptors
Description
cell signalling Mind Map on Cytokine receptors, created by fatimaelfitouri on 30/11/2013.
No tags specified
cell signalling
cell signalling
Mind Map by
fatimaelfitouri
, updated more than 1 year ago
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Created by
fatimaelfitouri
over 10 years ago
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Resource summary
Cytokine receptors
GHR
Jaks-stat-socs
inhibition
SOCS
PIAS
CIS
3 groups
type I
also known as hematopoietin receptor
Share 3 common components: either gp130, bc, gc
Divided into 3 groups depending on which component they utilise (gp130, bc or yc)
Type II
also known as interferon receptors
another group responds to proinflammatory cytokines
both type I and II lack intrinsic protein kinase activity, they are structurally distinct
cytokine
polypeptide or low molecular weight protein involved in cell-to-cell signaling
Acts in paracrine or autocrine fashion through specific cellular receptors
Can be produced by cells of any tissue and act on many cells involved in immune and inflammatory response
act like hormones
eg interleukins, TGF-b and chemokines
Cytokines that use the same receptor component usually have overlapping effects in the immune system
signalling
ligand binds to dimer receptor or monomer receptors that dimerse
ligand binding recruits JAK
jak2 transphosophorylate each other
stat1 is recruited, phosphorylated and dimerised with another stat
stat dimer translocated to the nucleus and regulates transcription
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