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58425
Schizo - Genetics
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Biological (Depression & Schizophrenia) Mind Map on Schizo - Genetics, created by n.c.wetmore on 26/04/2013.
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biological
depression & schizophrenia
biological
depression & schizophrenia
Mind Map by
n.c.wetmore
, updated more than 1 year ago
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n.c.wetmore
over 11 years ago
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Resource summary
Schizo - Genetics
Twin Studies
more closely you re bio related to someone with schizo, greater your prob of schizo is
GOTTESMAN 1991
MZ twins have higher concordat for schizo than DZ twins
MZ twins only have 50% not 100% concordance. MZ twins could differ because gene activated in over and suppressed in another or environment diff
TSUJITA ET AL 1998
greater similarity between DZ twins than siblings, DZ twins have same genetic resemblance as siblings but greater environment similarly incl. prenatal
Adopted Children Who Develop Schizophrenia
adoptive children with schizo - common in bio parents not adoptive
children with a moderately high probability of schizo even if adopted by mentally healthy parents
suggests genetic basis but also consistent with prenatal influence
pregnant mothers pass genes and provide prenatal environment for child
many smoke, drink, drugs, eat unhealthy during pregnant
they have a disproportionate number complications during pregnancy and delivery
study of adoptive children in finalnd found high probability of schizo or related conditions among children who had a bio mother with schizo
genetic risk itself or disordered family had less effect
WYNNE ET AL 2006
Efforts to Locate a Gene
more than dozen appear to be more common in people with schizo
DISC1 (disrupted in schizo 1)
controls production of dendritic spines and generation of new neurones in the hippo
DUAN ET AL 2007
other genes are important for brain development
control of transmission at glutamate synapses
connections between hippo and prefrontal cortex
haven't replicates any of these studies
if schizo depended on a single gene it would be hard to stay in 1% of population
those with schizo die younger than others
fewer than half as many children other people do
many cases of schizo arise from new mutations
mutations don't come around that often
proper brain development depends on hundreds of genes
mutation in one gene is rare but mutation in several hundred isn't
more likely possibility is deletion of gene - common error in reproduction
examined chromosomes of people with and without schizo
found genetic micro deletions and micro duplications in 5% control 15% schizo and 20% onset schizo before 18
leads to hypothesis that new mutation or deletion of any of a large number genes disrupts brain development and increase prob of schizo
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