10007789
Description
Quiz by Michael Jardine, updated more than 1 year ago
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Created by Michael Jardine
about 7 years ago
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Question 1
Question
The vast majority of cancers are:
Answer
-
Monoclonal
-
Polyclonal
Question 2
Question
Etymology.
The "Leuk-" part of leukaemia means what?
Answer
-
Blood
-
White
-
Cancer
Question 3
Question
Etymology.
The "-aemia" part of leukaemia means what?
Answer
-
Blood
-
White
-
Cancer
Question 4
Question
Most cancers are derived from what type of cells?
Answer
-
Epithelial
-
Mesenchymal
Question 5
Question
Blood cell malignancies.
The most obvious difference between Leukaemia and Lymphoma is what?
Answer
-
Leukaemia is mainly in circulation. Lymphoma is mainly in lymph nodes (or spleen).
-
Leukaemia is mainly in lymph nodes (or spleen). Lymphoma is mainly in circulation.
-
No noticeable differences.
Question 6
Question
Roughly what proportion of the cells in your body are blood cells?
Answer
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1 / 2
-
1 / 4
-
1 / 8
-
1 / 16
-
1 / 32
-
1 / 64
Question 7
Question
What is the etymology of Macrophages?
(which are a subcategory of Leukocytes)
Answer
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Macro- = "Big" -phage = "Eater"
-
Macro- = "Little" -phage = "Eater"
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Macro- = "Big" -phage = "Enzyme"
-
Macro- = "Little" -phage = "Enzyme"
Question 8
Question
Etymology.
Blast cells. What does "Blast" mean in Greek?
Answer
-
Bud
-
Destroyer
-
Eater
-
Builder
Question 9
Question
What are the distinguishing features of Blast Cells?
(select all that apply)
Answer
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Haematopoietic progenitor cells
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Highly proliferative
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Large, transcriptionally active nucleus
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Survival and proliferation dependent on Growth Factor signalling
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Hepatopoietic progenitor cells
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Fully mature cells
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Normally found in large quantities in blood vessels
Question 10
Question
True or false?
Mature blood cells typically have more active nuclei than blasts.
Answer
- True
- False
Question 11
Question
True or false?
-blasts are the most likely cell type to become Leukaemic.
Answer
- True
- False
Question 12
Question
True or false?
-blasts are the least likely cell type to become Leukaemic.
Answer
- True
- False
Question 13
Question
True or false?
Mature blood cells typically have less active nuclei than blasts.
Answer
- True
- False
Question 14
Question
There are 4 types of Leukaemia. These include:
(select all that apply)
Answer
-
ALL - Acute Lymphoblastic Leukaemia
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AML - Acute Myelogenous Leukaemia
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CLL - Chronic Lymphoblastic Leukaemia
-
CML - Chronic Myelogenous Leukaemia
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ALL - Acute Lymphatic Leukaemia
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AML - Acute Myelodysplastic Leukaemia
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CLL - Chronic Lymphatic Leukaemia
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CML - Chronic Myelodysplastic Leukaemia
Question 15
Question
Acute Leukaemias arise from [blank_start]__________[blank_end] .
Chronic Leukaemias arise from [blank_start]__________[blank_end] .
Answer
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Stem Cells
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Committed Precursors
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Late Precursors and Mature Forms
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Stem Cells
-
Committed Precursors
-
Late Precursors and Mature Forms
Question 16
Question
There are 3 ways to donate marrow.
1 - Bone marrow transplant (becoming less common, though)
2 - PBSC
3 - Cord Blood (saved since birth)
PBSC stands for [blank_start]__________[blank_end] Blood Stem Cell
Answer
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Purified
-
Peripheral
-
Progenitor
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Please don't fuck this up
Question 17
Question
The Philadelphia chromosome (AKA Bcr-Abl) is a translocation between chromosomes 9 and 22 that results in a fusion protein called "BCR-ABL". What is the effect of this?
Answer
-
Blocks myeloid differentiation in the progenitor stage
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Blocks myeloid differentiation in the haematopoietic stem cell stage
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Blocks lymphoid differentiation in the progenitor stage
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Blocks lymphoid differentiation in the haematopoietic stem cell stage
Question 18
Question
Bcr-Abl.
Bcr = Breakpoint Cluster Region protein
Abl = Abelson Murine Leukaemia viral oncogene homolog 1 (a non-receptor tyrosine kinase)
The fusion of the two results in what?
Answer
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Constitutive activation of the Abl kinase
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Inactivation of the Abl kinase
Question 19
Question
Lymphoma is a malignancy arising from which of the following?
Answer
-
Progenitor B and T cells in the peripheral lymphoid tissues
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Progenitor B and T cells in the bloodstream
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Erythrocytes in the bloodstream
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Leukocytes in the bloodstream
Question 20
Question
Which of the following are symptoms of Leukaemia?
(select all that apply)
Answer
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Hyperviscosity syndrome
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Bruising
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Anaemia
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Arthritis
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Splenomegaly
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Abnormal blood cell profiles (more nucleated cells in the blood)
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Abnormal blood cell profiles (fewer nucleated cells in the blood
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