PHSI3012 09-1 Atherothrombosis

What’s the most common type of heart disease, and leading cause of death?

There are two major categories of stroke. 80% are which one?

Platelets are disc-shaped fragments produced by __________.

Average platelet count is:

Which of the following are functional responses of platelets?

Shape change is a crucial functional response of platelets to …something. They change shape from [blank_start]__________[blank_end] to [blank_start]__________[blank_end]

Which receptor/ligand interactions occur during which bit?

Fibrin generation at the site of vascular injury has a crucial role in anchoring the thrombus to the vessel. It requires initiation of coagulation and generation of thrombin. This depends on Tissue Factor (TF) expression on the surface of [blank_start]__________[blank_end] and fibroblasts.

Platelet-mediated fibrin clot retraction shrinks the size of the blood clot. Thought to be important for stabilising the clot against shear forces of blood flow. This requires:

Which of the following are prothrombotic and which are antithrombotic? ADP: [blank_start]__________[blank_end]; Aspirin: [blank_start]__________[blank_end]; Epinephrine: [blank_start]__________[blank_end]; Clopidogrel: [blank_start]__________[blank_end]; Collagen: [blank_start]__________[blank_end]; Heparin: [blank_start]__________[blank_end]; Thrombin: [blank_start]__________[blank_end];

Does Aspirin prevent initial platelet adhesion?

Does Aspirin prolong skin bleeding time?

What’s the efficacy of Aspirin?

Does Aspirin inhibit prostacyclin synthesis?

Does Aspirin stimulate prostacyclin synthesis?

Does Aspirin suppress the release of thrombogenic factors from platelets?

Integrin αIibβ3 (GPIIbIIIa) inhibitors are:

Which of the following are CURRENT (not further potential) antithrombotic treatments:

PAR antagonists are under development as a potential novel antithrombotic. What’s PAR?