Complimentation Tests & Epistasis

Description

Year 2 Quiz on Complimentation Tests & Epistasis, created by gina_evans0312 on 16/12/2013.
gina_evans0312
Quiz by gina_evans0312, updated more than 1 year ago
gina_evans0312
Created by gina_evans0312 almost 11 years ago
594
0

Resource summary

Question 1

Question
The complimentation test is used to find out if mutations are allelic or non allelic
Answer
  • True
  • False

Question 2

Question
In what circumstances will a Complimentation Test give a false result?
Answer
  • When the mutation is recessive
  • When the mutation is dominant
  • When the mutated gene is part of a complex
  • Where proteins form multimers

Question 3

Question
Genotypes M1 & M2 are bred together, and a Wild Type result is obtained- are the mutations allelic
Answer
  • No- as the presentation of a wild type phenotypes shows there is at least one dominant wild type allele for each gene
  • Yes- The two mutations on the same allele are able to compliment each other sufficiently to produce a wild type phenotype

Question 4

Question
If M3 and M2 are bred together and they present as M2, what does this tell us about the mutation's location?
Answer
  • They are on the same allele- there is no dominant wild type allele to mask their activity
  • They are on separate alleles, but M2 has a far greater effect than previously thought

Question 5

Question
According to the above table, which mutations are allelic
Answer
  • M9 & M4
  • M8 & M6
  • M2
  • All of the above

Question 6

Question
A Complimentation Test can be fooled if the mutant protein can form a functioning heterodimer with the wild type protein
Answer
  • True
  • False

Question 7

Question
One gene is said to be epistatic to another if...
Answer
  • The presence of a double mutant exhibits the phenotype of the mutant gene
  • The presence of the wild type masks the phenotype of the mutant gene
  • A genes expression causes a change in the expression of another gene further down the pathway

Question 8

Question
Where are epistatic genes usually found in substrate dependent pathways?
Answer
  • Upstream
  • Downstream

Question 9

Question
A substrate dependent pathway is a series of positive and negative regulators that act on one another of the final product
Answer
  • True
  • False

Question 10

Question
This image is of a Switch Regulatory Pathway
Answer
  • True
  • False

Question 11

Question
Why should null alleles be used for epistatic analysis (i.e how to find out the order of gene function in a pathway)
Answer
  • The masking of alleles downstream becomes obvious
  • They are easier to make than hypomorphic alleles
  • They can be used for both Substrate Dependent and Switch pathways

Question 12

Question
How do we identify that the pathway effected by the (epistatic) mutation is a Switch Regulatory pathway?
Answer
  • If the mutation prevents the production of the final product
  • If the phenotype of a double mutant is different to the phenotype of either single mutant

Question 13

Question
The Rif1 & Rif2 strains are both causes lengthened telomeres, as shown in the diagram. Based on the Rif1/Rif2 double mutation, which of the two availible pathways (shown) is likely to be the one used?
Answer
  • Pathway A
  • Pathway B
Show full summary Hide full summary

Similar

Chromosome Mutations
gina_evans0312
Copy Number Variation
gina_evans0312
Alleles and Complimentation- Definitions
gina_evans0312
Chromosomal Abberations and Repair
gina_evans0312
Telomeres and Genetic Stability
gina_evans0312
Head, Neck and Back 2nd Sem- Anatomy 2nd Year- PMU
Med Student
Respiratory System 2nd Year PMU Anatomy
Med Student
Respiratory System Year 2/
Sole C
Fiction or NonFiction Year 1
Judy Stephenson
Fiction or NonFiction Year 2
Judy Stephenson
Anatomy Year 2 - Head, Neck and Back
Sole C