10007789
Descripción
Test por Michael Jardine, actualizado hace más de 1 año
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Creado por Michael Jardine
hace alrededor de 7 años
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Pregunta 1
Pregunta
The vast majority of cancers are:
Respuesta
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Monoclonal
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Polyclonal
Pregunta 2
Pregunta
Etymology.
The "Leuk-" part of leukaemia means what?
Respuesta
-
Blood
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White
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Cancer
Pregunta 3
Pregunta
Etymology.
The "-aemia" part of leukaemia means what?
Respuesta
-
Blood
-
White
-
Cancer
Pregunta 4
Pregunta
Most cancers are derived from what type of cells?
Respuesta
-
Epithelial
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Mesenchymal
Pregunta 5
Pregunta
Blood cell malignancies.
The most obvious difference between Leukaemia and Lymphoma is what?
Respuesta
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Leukaemia is mainly in circulation. Lymphoma is mainly in lymph nodes (or spleen).
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Leukaemia is mainly in lymph nodes (or spleen). Lymphoma is mainly in circulation.
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No noticeable differences.
Pregunta 6
Pregunta
Roughly what proportion of the cells in your body are blood cells?
Respuesta
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1 / 2
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1 / 4
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1 / 8
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1 / 16
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1 / 32
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1 / 64
Pregunta 7
Pregunta
What is the etymology of Macrophages?
(which are a subcategory of Leukocytes)
Respuesta
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Macro- = "Big" -phage = "Eater"
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Macro- = "Little" -phage = "Eater"
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Macro- = "Big" -phage = "Enzyme"
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Macro- = "Little" -phage = "Enzyme"
Pregunta 8
Pregunta
Etymology.
Blast cells. What does "Blast" mean in Greek?
Respuesta
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Bud
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Destroyer
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Eater
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Builder
Pregunta 9
Pregunta
What are the distinguishing features of Blast Cells?
(select all that apply)
Respuesta
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Haematopoietic progenitor cells
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Highly proliferative
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Large, transcriptionally active nucleus
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Survival and proliferation dependent on Growth Factor signalling
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Hepatopoietic progenitor cells
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Fully mature cells
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Normally found in large quantities in blood vessels
Pregunta 10
Pregunta
True or false?
Mature blood cells typically have more active nuclei than blasts.
Respuesta
- True
- False
Pregunta 11
Pregunta
True or false?
-blasts are the most likely cell type to become Leukaemic.
Respuesta
- True
- False
Pregunta 12
Pregunta
True or false?
-blasts are the least likely cell type to become Leukaemic.
Respuesta
- True
- False
Pregunta 13
Pregunta
True or false?
Mature blood cells typically have less active nuclei than blasts.
Respuesta
- True
- False
Pregunta 14
Pregunta
There are 4 types of Leukaemia. These include:
(select all that apply)
Respuesta
-
ALL - Acute Lymphoblastic Leukaemia
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AML - Acute Myelogenous Leukaemia
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CLL - Chronic Lymphoblastic Leukaemia
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CML - Chronic Myelogenous Leukaemia
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ALL - Acute Lymphatic Leukaemia
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AML - Acute Myelodysplastic Leukaemia
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CLL - Chronic Lymphatic Leukaemia
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CML - Chronic Myelodysplastic Leukaemia
Pregunta 15
Pregunta
Acute Leukaemias arise from [blank_start]__________[blank_end] .
Chronic Leukaemias arise from [blank_start]__________[blank_end] .
Respuesta
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Stem Cells
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Committed Precursors
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Late Precursors and Mature Forms
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Stem Cells
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Committed Precursors
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Late Precursors and Mature Forms
Pregunta 16
Pregunta
There are 3 ways to donate marrow.
1 - Bone marrow transplant (becoming less common, though)
2 - PBSC
3 - Cord Blood (saved since birth)
PBSC stands for [blank_start]__________[blank_end] Blood Stem Cell
Respuesta
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Purified
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Peripheral
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Progenitor
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Please don't fuck this up
Pregunta 17
Pregunta
The Philadelphia chromosome (AKA Bcr-Abl) is a translocation between chromosomes 9 and 22 that results in a fusion protein called "BCR-ABL". What is the effect of this?
Respuesta
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Blocks myeloid differentiation in the progenitor stage
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Blocks myeloid differentiation in the haematopoietic stem cell stage
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Blocks lymphoid differentiation in the progenitor stage
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Blocks lymphoid differentiation in the haematopoietic stem cell stage
Pregunta 18
Pregunta
Bcr-Abl.
Bcr = Breakpoint Cluster Region protein
Abl = Abelson Murine Leukaemia viral oncogene homolog 1 (a non-receptor tyrosine kinase)
The fusion of the two results in what?
Respuesta
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Constitutive activation of the Abl kinase
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Inactivation of the Abl kinase
Pregunta 19
Pregunta
Lymphoma is a malignancy arising from which of the following?
Respuesta
-
Progenitor B and T cells in the peripheral lymphoid tissues
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Progenitor B and T cells in the bloodstream
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Erythrocytes in the bloodstream
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Leukocytes in the bloodstream
Pregunta 20
Pregunta
Which of the following are symptoms of Leukaemia?
(select all that apply)
Respuesta
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Hyperviscosity syndrome
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Bruising
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Anaemia
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Arthritis
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Splenomegaly
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Abnormal blood cell profiles (more nucleated cells in the blood)
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Abnormal blood cell profiles (fewer nucleated cells in the blood
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