10319305
Descripción
Test por Michael Jardine, actualizado hace más de 1 año
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Creado por Michael Jardine
hace alrededor de 7 años
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Pregunta 1
Pregunta
What is the difference between cell growth and cell proliferation?
Respuesta
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Cell growth = increase in ONE cell's mass/size; Cell proliferation = increase in cell numbers.
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Cell growth = increase in cell numbers; Cell proliferation = increase in ONE cell's mass/size.
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No meaningful distinction. (/ distinction without substantial difference) (/ fuck all)
Pregunta 2
Pregunta
Which of the following is true?
Respuesta
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Control of cell proliferation is intrinsically linked to cell growth.
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Control of cell growth is intrinsically linked to cell proliferation.
Pregunta 3
Pregunta
The order of the rough phases of the cell cycle are as follows:
G1 > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] > [blank_start]_____[blank_end] (then back to G1 again)
Respuesta
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S
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G2
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M
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Cytokinesis
Pregunta 4
Pregunta
G1 phase stands for, and involves, what?
Respuesta
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Growth phase
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Gap phase
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Cell growth
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Monitoring
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Mitosis
Pregunta 5
Pregunta
G2 phase stands for, and involves, what?
Respuesta
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Growth phase
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Gap phase
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Cell growth
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Monitoring
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Mitosis
Pregunta 6
Pregunta
S phase stands for, and involves, what?
Respuesta
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DNA synthesis
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Selectivity
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Cell growth
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Mitosis
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Stretching
Pregunta 7
Pregunta
M phase stands for, and involves, what?
Respuesta
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Mitosis
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Meiosis
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Monitoring
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DNA synthesis
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Cell division
Pregunta 8
Pregunta
Cdks (Cyclin-Dependent KinaseS) are regulated by:
Respuesta
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Cyclins
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Phosphorylation
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Both of the above
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[none of the above]
Pregunta 9
Pregunta
Mitogens are:
Respuesta
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Things that stimulate cell division (e.g. hormones, cytokines).
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Stimulate migration.
Pregunta 10
Pregunta
Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.
Acquiring the ability to synthesise mitogens (resulting in autocrine stimulation) is one way this can happen. Some examples of this are:
Respuesta
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PDGF, TGFα - glioblastomas & osteosarcoma
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EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)
Pregunta 11
Pregunta
Disordered signaling in cancer.
Many cancer-critical genes (oncogenes or tumour-suppressor genes) regulate cell growth and proliferation.
e.g. a mutation may lead to independence from mitogen-dependence.
Constitutive expression of their receptors (resulting in increased sensitivity?) is one way this can happen. Some examples of this are:
Respuesta
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PDGF, TGFα - glioblastomas & osteosarcoma
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EGF-R/erbB (epidermal growth factor receptor); HER2 (human epidermal growth factor receptor)
Pregunta 12
Pregunta
HER2 (Human Epidermal growth factor Receptor) mutations are present in:
Respuesta
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Overexpressed in breast cancer.
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Overexpressed in stomach, brain, and breast cancer.
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Abnormally present in glioblastomas and osteosarcoma.
Pregunta 13
Pregunta
EGF-R / erbB (Epidermal Growth Factor Receptor) and cancer...
Respuesta
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Up-regulated in stomach, brain, and breast cancer.
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Up-regulated in breast cancer.
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Abnormally present in gliobastomas & osteosarcoma.
Pregunta 14
Pregunta
True or false: Mitogens [usually?] act through the ras/raf/ERK cascade.
Respuesta
- True
- False
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