10320480
Descripción
Test por Michael Jardine, actualizado hace más de 1 año
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Creado por Michael Jardine
hace alrededor de 7 años
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Pregunta 1
Pregunta
True or false:
Cells which have entered senescence have a large, flattened morphology "like poached eggs".
Respuesta
- True
- False
Pregunta 2
Pregunta
Mutations in p53 and/or Rb can lead to:
Respuesta
-
Bypassing senescence and crisis.
-
Bypassing senescence and entering crisis.
-
Entering crisis.
-
[none of the above]
Pregunta 3
Pregunta
Cells in "crisis" have which of the following traits?
(select all that apply)
Respuesta
-
Massive cell death
-
Reduced cell death
-
Increased genomic stability
-
Genomic instability
Pregunta 4
Pregunta
The Hayflick limit is:
Respuesta
-
The number of divisions a cell can undergo before entering senescence.
-
(not this one)
Pregunta 5
Pregunta
Telomeres shorten by ~[blank_start]_____[blank_end] bp with each round of cell division.
Respuesta
-
5 - 15
-
50 - 150
-
500 - 1,500
-
5,000 - 15,000
-
130 - 210
-
2,000 - 40,000
Pregunta 6
Pregunta
There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
What does ALT stand for?
[blank_start]_____[blank_end]
Respuesta
-
Alternative Lengthening of Telomeres
Pregunta 7
Pregunta
Which [non-cancerous] cell type does NOT have shortening telomeres during replication?
Respuesta
-
Germ line cells
-
Stem cells
-
Cardiomyocytes
Pregunta 8
Pregunta
Telomerase is:
Respuesta
-
An enzyme
-
A protein
-
A molecule
Pregunta 9
Pregunta
Which telomere maintenance mechanism is used in the majority of cancers?
Respuesta
-
Telomerase
-
ALT
Pregunta 10
Pregunta
Telomerase can be detected using which of the following methods:
(select all that apply)
Respuesta
-
TRAP (Telomere Repeat Amplification Protocol) assay
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TRF (Terminal Restriction Fragment) assay
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APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
Pregunta 11
Pregunta
ALT can be detected using which of the following methods?
(select all that apply)
Respuesta
-
TRAP (Telomere Repeat Amplification Protocol) assay
-
TRF (Terminal Restriction Fragment) assay
-
APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
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