Neuromuscular Blockade

Descripción

Diplomat of ABA (Fundamental Topics in Anesthesiology) Medicine Test sobre Neuromuscular Blockade, creado por Mike Ru el 28/04/2018.
Mike Ru
Test por Mike Ru, actualizado hace más de 1 año
Mike Ru
Creado por Mike Ru hace alrededor de 6 años
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Resumen del Recurso

Pregunta 1

Pregunta
Use of succinylcholine to facilitate endotracheal intubation would be acceptable (“safe”) in which one of the following situations:
Respuesta
  • 80 y.o. female patient 2 days after 40% body surface area burn
  • 18 y. o. male one week after spinal cord transection injury
  • 12 y.o. with Duchene’s muscular dystrophy
  • 22 y. o. with evolving respiratory failure secondary to Guillian-Barre’
  • 27 y. o. female with myasthenia gravis

Pregunta 2

Pregunta
A patient taking which of the following drugs would most commonly be associated with resistance to (nondepolarizing) NMB drugs:
Respuesta
  • Quinidine
  • Phenytoin
  • Cyclophosphamide
  • Aminoglycosides
  • Magnesium

Pregunta 3

Pregunta
The MOST important parameter that determines the speed of onset for NMB drugs is:
Respuesta
  • Potency
  • Lipophilicity
  • Ionization
  • Plasma clearance
  • E. Receptor affinity

Pregunta 4

Pregunta
A characteristic common to current aminosteroid-based NMB drugs such as vecuronium or rocuronium is:
Respuesta
  • Significant histamine release after a bolus injection
  • Vagolysis producing tachycardia
  • Hofmann elimination
  • Deacetylation in the liver
  • Production of laudanosine as the primary metabolite

Pregunta 5

Pregunta
Clinical data support that when the TOFR exceeds [blank_start]__[blank_end], anesthesia providers have trouble assessing the presence of fade
Respuesta
  • 0.4
  • 0.2
  • 0.7
  • 0.9

Pregunta 6

Pregunta
TOF count of 3 would equate to a twitch suppression of [blank_start]__[blank_end]%
Respuesta
  • 55
  • 75
  • 85
  • 90

Pregunta 7

Pregunta
Once the TOF ratio exceeds [blank_start]0.60[blank_end], fade to DBS generally cannot be detected subjectively
Respuesta
  • 0.60
  • 0.40
  • 0.70
  • 0.85

Pregunta 8

Pregunta
What is true about Tetanic stimulation (TET)?
Respuesta
  • During partial depolarizing block, fade is not observed in response to tetanic stimulation
  • Tetanic stimulation is not painful
  • Muscular fatigue usually develop at a stimulation frequency of 50 Hz
  • Fade is thought to be an effect of a depolarizing agent on the presynaptic nerve membrane

Pregunta 9

Pregunta
Which statement about posttetanic count is NOT correct?
Respuesta
  • The number of posttetanic count twitches is inversely related to time until the first regular TOF twitch returns
  • Posttetanic count used when TOF or DBS is absent to estimate recovery time
  • Posttetanic count uses tetany followed by TOF at frequency of 1 Hz
  • The main use of posttetanic count is when profound neuromuscular block is not required

Pregunta 10

Pregunta
Correct statements about objective monitoring techniques include:
Respuesta
  • Mechanomyography (MMG) measures isotonic contraction of peripheral muscles in response to nerve stimulation
  • Acceleromyography (AMG) calculates the force of contraction of a muscle using a miniature piezoelectric transducer
  • Electromyography (EMG) measures the electrical activity (compound muscle action potential) of a stimulated muscle
  • Kinemyography (KMG) detects the acceleration of the thumb contraction in response to electrical stimulation of a nerve

Pregunta 11

Pregunta
All of the following are examples of Benzylisoquinolinium compounds consist of two quaternary ammonium groups joined by methyl groups EXCEPT:
Respuesta
  • D-tubocurarine
  • Atracurium
  • Mivacurium
  • Pancuronium
  • Cisatracurium

Pregunta 12

Pregunta
Train-of-four (TOF) has all of the following characteristics, EXCEPT:
Respuesta
  • TOF consists of four ST stimuli at a frequency of 4 Hz
  • TOF does not require a “baseline” or “control” muscle response
  • TOF “fade” is defined as a weaker fourth twitch than the first twitch
  • TOF is delivered every 15-20 sec to prevent potentiation of subsequent responses
  • TOF ratios >0.40 cannot be reliably detected subjectively (visually or tactilely)

Pregunta 13

Pregunta
Double burst stimulation (DBS) characteristics include all of the following, EXCEPT:
Respuesta
  • The two mini-tetanic bursts are separated by 0.5 sec
  • DBS is delivered no more frequently than every 20 sec to prevent subsequent response potentiation
  • In DBS, similar to TOF pattern, no control (“baseline”) muscle response is needed
  • DBS ratios >0.60 cannot be reliably detected by subjective (tactile, visual) means
  • In awakening patients, DBS is more painful than TOF, but less so than tetanic stimulation

Pregunta 14

Pregunta
Potential side-effects associated with the use of succinylcholine include all of the below, EXCEPT:
Respuesta
  • Myalgia
  • Tachycardia
  • Anaphylaxis
  • Hyperkalemia

Pregunta 15

Pregunta
Since sugammadex has no direct cholinergic properties, anesthesiologist do not require the ready availability of an anticholinergic like glycopyrrolate at the time of reversal.
Respuesta
  • True
  • False

Pregunta 16

Pregunta
When administering sugammadex through a peripheral IV, it is important to note that the drug has a physical incompatibility with all of the following drugs except:
Respuesta
  • Verapamil
  • Dexamethasone
  • Ranitidine
  • Odansetron
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