16366412
Descripción
Test por Berfin Miiau, actualizado hace más de 1 año
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Creado por Berfin Miiau
hace casi 6 años
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Pregunta 1
Pregunta
the main routes of enteral administration of drugs are
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oral
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by injection
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rectal
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per mucosa
Pregunta 2
Pregunta
Advantages of the oral route of drug administration are
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easily self-administered
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toxicity and overdose may be overcome with antidotes
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drugs avoid first-pass metabolism
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drugs go directly into the systemic circulation
Pregunta 3
Pregunta
Advantages of the rectal route of drug administration are
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suitable for vomiting patients
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suitable for children
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suitable for unconscious patients
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a way to avoid first-pass metabolism
Pregunta 4
Pregunta
Disadvantages of iv drug administration are
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a trained staff is required
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risk of bacterial contamination at the site of injection
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it is painful and stressful for the patient
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drugs undergo first-pass metabolism in the liver
Pregunta 5
Pregunta
Point out the correct statements for iv drug administration
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aqueous solutions can be administered iv
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oil solutions can be administered iv
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has the highest bioavailability
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used for treatment of life-threatening conditions
Pregunta 6
Pregunta
The subject of pharmacokinetics is
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drug absorption and distribution
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drug biotransformation
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drug elimination
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drug biological activity
Pregunta 7
Pregunta
Point out the correct statements for passive diffusion
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does not require energy
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requires energy
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involves a carrier
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drugs move from high to lower concentration
Pregunta 8
Pregunta
The diffusion of lipid soluble drugs
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depends on the charge of the drug molecule
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does not depend on the charge of the drug molecule
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is penetration through aqueous channels or pores
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is penetration through the biological membranes
Pregunta 9
Pregunta
A drug-weak acid will be absorbed
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in a medium with low pH
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in a medium with high pH
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in the stomach
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in the intestine
Pregunta 10
Pregunta
A drug-weak base will be absorbed
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in a medium with low pH
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in a medium with high pH
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in the stomach
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in the intestine
Pregunta 11
Pregunta
Point out the correct statements for active drug transport
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it is energy- dependent
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it is not energy- dependent
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requires carriers
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does not require carriers
Pregunta 12
Pregunta
Point out the correct statement for drugs bound to plasma proteins
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bound drugs are pharmacologically active
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only the unbound drugs can act on target sites in the tissues
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only the bound drugs are available to the process of elimination
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drugs may displace each other from the binding proteins
Pregunta 13
Pregunta
Drug metabolism may
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increase a drug's pharmacological activity
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decrease a drug's pharmacological activity
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change the pharmacological effects of a drug
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change the toxicity of a drug
Pregunta 14
Pregunta
first phase liver metabolism reactions include
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acetylation
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conjugation
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reduction
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oxidation
Pregunta 15
Pregunta
Second phase liver metabolism reactions include
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acetylation
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conjugation
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reduction
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oxidation
Pregunta 16
Pregunta
Phase I of drug metabolism
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may or may not involve cytochrome P450 system
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phase I reactions convert lipophilic molecules to more polar molcecules
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includes alcohol dehydrogenation, amine oxidation, hydrolysis
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consists of conjugation reactions
Pregunta 17
Pregunta
Renal excretion of a drug will be reduced if
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the drug is a weak acid and the urine is alkaline
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the drug is a weak acid and the urine is acidic
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the drug is a weak base and the urine is alkaline
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the drug is a barbiturate and the urine is alkaline
Pregunta 18
Pregunta
Drug pharmacodynamics includes
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drug effects
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mechanisms of drug action
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drug elimination
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how the organism changes drugs
Pregunta 19
Pregunta
The changes that occur due to the interaction between drug molecules and organism structures are called
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drug effect
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drug action
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adverse drug reaction
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placebo effect
Pregunta 20
Pregunta
The organism response as a result of the changes that have occured due to its interaction with the drug is called
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drug action
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drug effect
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adverse drug reaction
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placebo effect
Pregunta 21
Pregunta
What is characteristic for a drug receptor
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induces (generates) a change in organism functions
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has selectivity
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has sensitivity
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has specifity
Pregunta 22
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Agonists are ligands which
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have affinity
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block receptors
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have intrinsic activity
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bind to the receptor
Pregunta 23
Pregunta
Antagonists are ligands which
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have strong affinity
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have intrinsic activity
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block the receptor
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do not have intrinsic activity
Pregunta 24
Pregunta
Therapeutic margin is the
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difference between maximal toxic and minimal therapeutic doses
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ratio between minimal toxic and minimal therapeutic doses
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difference between mean lethal and mean effective doses
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ratio between lethal and mean effective doses
Pregunta 25
Pregunta
Drugs' therapeutic index is the
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difference between minimal toxic and minimal therapeutic doses
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ratio between minimal toxic and minimal therapeutic doses
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difference between mean lethal and mean effective doses
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ratio between mean lethal and mean effective doses
Pregunta 26
Pregunta
Types of drug interaction are
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synergy
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antagonism
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synergy/ antagonism
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chemical antagonism (formation of complexes)
Pregunta 27
Pregunta
Potentiation can be observed during the concomitant use of
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Fentanyl and Droperidol
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Heparin and Protamine
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Amoxicillin and Clavulonic acid
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Diazepam and Flumazenil
Pregunta 28
Pregunta
Full competitive antagonist of opioid receptors, administered in acute opioid intoxication is
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Allylnormorphine
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Methadone
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Naloxone
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Flumazenil
Pregunta 29
Pregunta
Chemical antagonism or complex formation can be observed in
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Morphine and Naloxone
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Diazepam and Flumazenil
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Epinephrine and Histamine
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Iron preparation and Deferroxamine
Pregunta 30
Pregunta
Which of the following are enzyme inducers
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Phenytoin
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Phenobarbital
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Metamizol
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Metronidazole
Pregunta 31
Pregunta
Multiple drug administration could lead to
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drug tolerance
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drug dependence
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drug accumulation
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allergic reactions
Pregunta 32
Pregunta
Drug addicition/ dependence involves
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drug tolerance
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physical dependence
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psychological dependence
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allergy
Pregunta 33
Pregunta
Antiseptics are used for
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decontamination of laundry and sanitary facilities
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decontamination of skin and mucous membranes
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internal administration
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treatment of fever
Pregunta 34
Pregunta
Disinfectants are used for decontamination of
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urine, faeces and other
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mouth
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instruments
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clothing and underwear
Pregunta 35
Pregunta
Antiseptics and disinfectants are
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detergents
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barbiturates
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oxidizing agents and halogen derivatives
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phenols
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