Pregunta 1
Pregunta
In chronic lympholeukemia in the liver can be seen
Respuesta
-
myeloblasts
-
mature lymphocytes and single lymphoblasts
-
focal leukemic infiltrates in the portal spaces
-
leukemic infiltrates in the sinusoids
Pregunta 2
Pregunta
Chronic myeloleukemia causes the following changes in liver
Respuesta
-
effaced lobular structure
-
hypertrophy and hyperplasia of hepatocytes
-
atrophy of hepatocytes
-
leukemic infiltrates in the sinusoids
Pregunta 3
Pregunta
In chronic myeloleukemia we observe the following
Respuesta
-
long remissions even without treatment
-
extreme hepato-splenomegaly
-
anemia, hemorrhages, infections
-
splenic infarctions
Pregunta 4
Pregunta
Which are the clinical phases of chronic myeloleukemia?
Respuesta
-
chronic stable phase
-
accelerated phase
-
blast crisis
-
none of the above
Pregunta 5
Pregunta
In Hodgkin lymphoma, mixed cellularity type
Respuesta
-
there can be seen numerous eosinophils
-
we can observe areas with necrosis
-
intact histological lymph node structure
-
giant bi-nucleated cells, called ‘mirror image"
Pregunta 6
Pregunta
Plasmocytoma has the following features:
Respuesta
-
Reed-Sternberg tumor cells
-
Jelly-like raspberry red osteolytic bone lesion
-
The tumor cells have a large vacuolar nucleus with prominent nucleolus
-
The tumor cells have a round eccentric nucleus with a pale halo around it
Pregunta 7
Pregunta
Which of the following are examples of pathological processes in the oral cavity that can have an effect of internal organs?
Pregunta 8
Pregunta
Which avitaminosis can be associated with changes in the oral cavity?
Respuesta
-
vit. B6
-
vit. B12
-
vit. D
-
none of the above
Pregunta 9
Pregunta
Vitamin B12 deficiency can cause the following changes in the oral cavity
Pregunta 10
Pregunta
What type of examination you will suggest to your patient if you diagnose him/her with atrophic glossitis (Hunter’s tongue)?
Respuesta
-
colonoscopy
-
dermatoscopy
-
gastroscopy
-
hysteroscopy
Pregunta 11
Pregunta
If a patient with atrophic glossitis is examined with gastroscopy, what can be the findings in gastric mucosa?
Pregunta 12
Pregunta
The risk of which disease does atrophic autoimmune gastritis carry?
Pregunta 13
Pregunta
What are the usual changes in leukoplakia?
Respuesta
-
the epithelium is hyperkeratotic
-
acanthosis in the epithelium
-
chronic inflammation
-
dysplasia in the epithelium can be observed
Pregunta 14
Pregunta
What can we observe in leukoplakia?
Respuesta
-
parakeratosis
-
dysplasia
-
carcinoma in situ
-
diabetes
Pregunta 15
Pregunta
Which of the following 15 true of pleomorphic adenoma of the parotid gland
Pregunta 16
Pregunta
In chronic tonsillitis we can observe the following
Pregunta 17
Pregunta
The typical histological picture of epulis includes
Respuesta
-
Langhans giant multinuclear cells
-
Fresh heamorrhages and hemosiderin
-
Osteoclast-type multinuclear giant cells
-
It is a true tumor
Pregunta 18
Pregunta
Adamantinoma (amelloblastoma) is
Pregunta 19
Pregunta
Why is it necessary to comment on the presence or absence of H.pylori in gastric biopsies?
Respuesta
-
H. pylori is a risk factor for MALT lymphoma
-
H. pylori is a risk factor for duodenal cancer
-
H. pylori causes chronic gastritis
-
H. pylori is a severe fungal infection
Pregunta 20
Pregunta
Which of the following are possible complications of chronic gastric ulcer?
Pregunta 21
Pregunta
Which special stain help us determine the presence of H. pylori in gastric biopsies?
Respuesta
-
Van Gieson
-
Giemsa
-
Congo Red
-
Immunohistochemistry
Pregunta 22
Pregunta
The following changes can be observed in acute duodenal ulcer
Respuesta
-
fibrinoid necrosis at the ulcer base
-
inflammatory infiltrate with lymphocytes and plasma cells
-
ulceration penetrating through muscularis mucosae, reaching muscularis propria
-
it often undergoes malignant transformation
Pregunta 23
Pregunta
What histological types of gastric cancer do you recognize?
Pregunta 24
Pregunta
In phlegmonous appendicitis we can observe the following
Respuesta
-
peri-appendicitis
-
lymphocytic infiltration in the mucosa
-
neutrophilic infiltration throughout the thickness of the wall of the appendix
-
constriction of the blood vessels of the serosa
Pregunta 25
Pregunta
Phlegmonous appendicitis is characterized by
Respuesta
-
purulent exudate in the lumen
-
hypoplasia of the lymph follicles
-
hyperplastic activated lymph follicles
-
hyperemic blood vessels of the serosa
Pregunta 26
Pregunta
Gangrenous appendicitis is characterized by
Respuesta
-
lymphocytic infiltration of the mucosa
-
thrombosis of blood vessels
-
necrosis of the wall of the appendix
-
severe inflammation through the wall of the appendix
Pregunta 27
Pregunta
What are the causes which may lead to micro-nodular liver cirrhosis?
Respuesta
-
acute viral hepatitis
-
chronic viral hepatitis
-
cardiogenic shock
-
chronic alcoholism
Pregunta 28
Pregunta
Which of the types of necrosis are found in chronic active hepatitis?
Respuesta
-
piece-meal necrosis
-
adjacent necrosis
-
bridging necrosis
-
caseous necrosis
Pregunta 29
Pregunta
Why the level of calcium in the blood has prognostic value in acute pancreatitis?
Respuesta
-
calcium is deposited in the bones
-
calcium levels in the blood lower with the progression of steato-necrosis
-
calcium reacts with fatty acids to form soaps
-
it has no prognostic value
Pregunta 30
Pregunta
Some of the gross features of acute pancreatitis are
Respuesta
-
enlarged liver
-
steatonecrosis of the fatty tissue around and inside the pancreas
-
hemorrhages in the tissues of the pancreas
-
fibrosis in the tissues of the pancreas
Pregunta 31
Pregunta
What histological changes can be observed in chronic hepatitis?
Pregunta 32
Pregunta
Chronic cholecystitis is characterized by the following
Respuesta
-
often it is accompanied by cholelithiasis
-
it has no association with cholelithiasis
-
can cause adhesions
-
it is caused by viral infection
Pregunta 33
Pregunta
Which of the following can be complications caused by chronic cholecystitis?
Pregunta 34
Pregunta
After consuming poisonous mushrooms, a patient shows signs of acute liver failure with progressive reduction of the size of the liver. What process has developed in the liver?
Respuesta
-
acute viral hepatitis
-
massive hepatic necrosis
-
hepatocellular carcinoma
-
none of the above
Pregunta 35
Pregunta
After consuming poisonous mushrooms, a patient shows signs of acute liver failure with progressive reduction of the size of the liver. Besides liver failure, what other complication can worsen the patient’s clinical condition?
Pregunta 36
Pregunta
Which of the following can occur after a streptococcal tonsillitis?
Respuesta
-
post-infectious cholecystitis
-
post-infectious glomerulonephritis
-
minimal change disease of the kidneys
-
acute rheumatism
Pregunta 37
Pregunta
Which types of glomerulonephritis are clinically presented by nephritic syndrome
Respuesta
-
diffuse endocapillary glomerulonephritis
-
rapidly progressing glomerulonephritis
-
minimal change disease
-
membranous glomerulonephritis
Pregunta 38
Pregunta
Which types of glomerulonephritis are clinically presented by nephrotic syndrome
Respuesta
-
diffuse endocapillary glomerulonephritis
-
rapidly progressing glomerulonephritis
-
minimal change disease
-
membranous glomerulonephritis
Pregunta 39
Pregunta
What findings can be observed in glomerulonephritis?
Respuesta
-
Klebsiella
-
E.coli
-
Streptococcus
-
The urine is sterile
Pregunta 40
Pregunta
Which type of glomerulonephritis is ‘crescentic’?
Respuesta
-
minimal change disease
-
rapidly progressing glomerulonepbhritis
-
membranous glomerulonephritis
-
diffuse endocapillary glomerulonephritis
Pregunta 41
Pregunta
‘Big white kidney’ can be observed in the following cases
Respuesta
-
rapidly progressing glomerulonephritis
-
amyloidosis of the kidney
-
minimal change disease
-
nephrosclerosis glomerulonephritica
Pregunta 42
Pregunta
Which of the following histological changes are associated with tubal pregnancy?
Respuesta
-
chorionic villi and decidual changes of the endometrium
-
monstrous trophoblast, hydropic chorionic villi
-
hematoma in fallopian tube, chronic villi invading the muscle layer of the tube, decidual changes of the endometrium
-
cervical intraepithelial lesion, third grade
Pregunta 43
Pregunta
Which of the following histological changes are associated with mola hydatidosa?
Respuesta
-
chronic villi and decidual changes of the endometrium
-
monstrous trophoblast, hydropic chorionic villi without fetal blood capillaries
-
hematoma in the fallopian tube, chorionic villi invading the muscle layer of the tube, decidual changes of the endometrium
-
cervical intraepithelial lesion, third grade
Pregunta 44
Pregunta
Which of the following histological changes are associated with abortion (miscarriage)?
Respuesta
-
chronic villi and decidual changes of the endometrium
-
monstrous trophoblast, hydropic chorionic villi without fetal blood capillaries
-
hematoma in the fallopian tube, chorionic villi invading the muscle layer of the tube, decidual changes of the endometrium
-
cervical intraepithelial lesion, third grade
Pregunta 45
Pregunta
Specify the associated clinical symptoms in dysplasia and carcinoma in situ of the uterine cervix
Pregunta 46
Pregunta
Why if curettage from a suspected pregnancy shows only decidual changes, the gynecologist should be notified immediately?
Respuesta
-
there is an increased risk for endometrial carcinoma
-
there is an increased risk of associated mola hydatidosa
-
there is an increased risk of associated intraepithelial lesion of the cervix
-
there is a high risk of associated tubal pregnancy
Pregunta 47
Pregunta
Mola hydatidosa has the following characteristics
Respuesta
-
grossly it resembles grape-like structures
-
chronic villi have fetal capillaries
-
chronic villi are with hydropic edema
-
chronic villi lack fetal blood vessels
Pregunta 48
Pregunta
Examples of ovarian cysts are
Pregunta 49
Pregunta
Which hormones play a role in breast diseases?
Respuesta
-
somatotropin
-
oxytocin
-
estrogen
-
progesterone
Pregunta 50
Pregunta
How does the breast cancer metastasize?
Pregunta 51
Pregunta
Select the epithelial ovarian tumors
Respuesta
-
Granulosa cell tumor
-
Thecoma
-
Brenner’s tumor
-
Androblastoma
Pregunta 52
Pregunta
Which of the following are epithelial ovarian tumors?
Respuesta
-
Thecoma
-
Serous cystadenoma
-
Dysgerminoma
-
Brenner’s tumor
Pregunta 53
Pregunta
Which of the following are sex-cord stromal ovarian tumors?
Respuesta
-
granulosa cell tumor
-
thecoma
-
dysgerminoma
-
androblastoma
Pregunta 54
Pregunta
Which of the following ovarian tumors are benign?
Pregunta 55
Pregunta
Which of the following ovarian tumors are malignant?
Pregunta 56
Pregunta
In fibro-cystic breast disease we find the following
Pregunta 57
Pregunta
In fibroadenoma of the breast we find
Pregunta 58
Pregunta
Benign prostate hyperplasia is seen most commonly in
Pregunta 59
Pregunta
Prostate carcinoma is usually seen in
Pregunta 60
Pregunta
Which two markers are valuable for the diagnosis of prostate carcinoma?
Respuesta
-
PSA
-
HER2
-
PAP
-
Estrogen receptors
Pregunta 61
Pregunta
What pathogenetic mechanism can be used for the therapy of prostate carcinoma?
Respuesta
-
hormonal therapy - anti-testosterone drugs
-
hormonal therapy - anti-progesterone drugs
-
treatment with monoclonal antibodies
Pregunta 62
Pregunta
Which of the following types of cancer metastasize to bone?
Respuesta
-
ovarian cancer
-
renal cancer
-
breast cancer
-
thyroid gland cancer
Pregunta 63
Pregunta
Bone metastases are observed in which
Respuesta
-
gastric cancer
-
ovarian cancer
-
prostate cancer
-
breast cancer
Pregunta 64
Pregunta
Which of the following statements are true for Grave’s disease
Respuesta
-
it is the most common cause for hypothyroidism
-
exophthalmos in some patients
-
pretibial myxedema
-
usually most patients are euthyroid
Pregunta 65
Pregunta
The following is true for Grave’s disease
Respuesta
-
it causes hyperthyroidism
-
autoantibodies against TSH-receptors
-
affects more men than women
-
thyroid stimulating IgG is the cause
Pregunta 66
Pregunta
Histologically in Grave’s disease we can find
Respuesta
-
nodular colloid goiter
-
signs of thyroid hyperfunction
-
small thyroid follicles with small amounts of diluted colloid
-
many resorbtive vacuoles in the thyroid follicles
Pregunta 67
Pregunta
In nodular toxic goiter we can observe the following
Pregunta 68
Pregunta
Which of the following are renal complications of diabetes?
Pregunta 69
Pregunta
In goiter we observe
Respuesta
-
cystically dilated thyroid follicles
-
histological accommodation of the epithelium lining the follicles
-
papillary folds of the epithelium of the follicles
-
diluted, scarce colloid
Pregunta 70
Pregunta
Hashimoto’s thyroiditis is characterized by
Respuesta
-
the thyroid follicles are dilated, filled with large amounts of concentrated colloid
-
atypical looking cells called oncocytes
-
the thyroid follicles are replaced by lymph follicles
-
these lymphoid follicles have pale germinal centers
Pregunta 71
Pregunta
Pneumococcus usually causes infections of the CNS in
Respuesta
-
newboms
-
adults
-
teenagers
-
toddlers
Pregunta 72
Pregunta
Haemophylus influenze is the most common etiological agent for infections of the CNS in
Respuesta
-
newborns
-
adults
-
teenagers
-
toddlers
Pregunta 73
Pregunta
Escherichia coli is the most common etiological agent from infections of the CNS in
Respuesta
-
newborns
-
adults
-
teenagers
-
toddlers
Pregunta 74
Pregunta
Neisseria meningitidis is the most common etiological agent from infections of the CNS in
Respuesta
-
newborns
-
adults
-
teenagers
-
toddlers
Pregunta 75
Pregunta
Which of the following statements are true for tumors of the CNS?
Respuesta
-
metastatic tumors to the brain are more common than the primary
-
primary tumors of the CNS often metastasize outside the CNS
-
primary tumors of the CNS almost never metastasize outside the CNS
-
most important factor for the outcome is the tumor location
Pregunta 76
Pregunta
Which are the purposes of pathological autopsy?
Respuesta
-
to accuse the clinicians of medical malpractice
-
to establish the cause of death and the definitive diagnosis
-
to help and educate clinicians and to improve their work
-
to help the-relatives of the deceased to convict the doctors
Pregunta 77
Pregunta
Which are the conditions for an autopsy to be done?
Respuesta
-
death occurred in a hospital due to a disease
-
available medical history of the patient
-
presence of the treating doctor
-
all of the listed above
Pregunta 78
Pregunta
What are the characteristics of a frozen section?
Respuesta
-
urgent diagnosis given during an operation
-
the preparation of the tissue samples is done by a paraffin method
-
the preparation of the tissue samples is done on a freezing microtome
-
sometimes the diagnosis is not exactly clear because of the preparation method but information like “malignant tumor”, “benign tumor” or “inflammation” is given to the surgeons to know how to proceed with the operation
Pregunta 79
Pregunta
Which fixative is most commonly used?
Respuesta
-
Bouin solution
-
Absolute alcohol
-
Formalin 10%
-
Salts of heavy metals
Pregunta 80
Pregunta
What fixative should be used for a liver biopsy from a baby with a suspected inherited metabolic disease?
Respuesta
-
Formalin 10
-
1,5-4% glutaraldehyde
-
Frozen section
-
Zenker’s fixative
Pregunta 81
Pregunta
What is the role of immunohistochemical stains?
Respuesta
-
to give urgent answers about the diagnosis or at least orientation about the pathological process during surgery
-
to determine the histogenesis of the tumor especially in highly undifferentiated malignant tumors
-
to determine the proliferative activity and the hormonal receptors of the tumor that is highly important for the treatment
-
to help determine the cause of death
Pregunta 82
Pregunta
Cytokeratin, S-100 protein, Vimentin, Desmin, CD-20 are examples of
Pregunta 83
Pregunta
In which cases a pathological autopsy is performed?
Respuesta
-
when there is suspicion for diagnostic or therapeutic malpractice
-
death of a person outside the hospital
-
when there is suspicion of violent death
-
death of a patient in the hospital and when the relatives don’t ask the principal to cancel the autopsy
Pregunta 84
Pregunta
Which of the followings is not a part of performing an autopsy
Pregunta 85
Pregunta
Size, shape, elasticity, consistency, color and cut surface are characteristics of
Respuesta
-
microscopic examination of organs
-
gross examination of organs
-
ultramicroscopic examination of organs
-
none of the listed
Pregunta 86
Pregunta
Indicate correctly the name of the described test.
The pericardial sac is cut in Y-like section and filled with water, after that, in the presence of a witness, the right ventricle is punctured with a knife
Pregunta 87
Pregunta
Indicate correctly the name of the described test.
The pulmonary artery is cut at the place of truncus pulmonalis. Tweezers are inserted and the content of the artery is taken out for examinationion
Pregunta 88
Pregunta
Indicate correctly the name of the described test.
A pocket between the skin and the ribs is formed and is filled with water. In the presence of a witness, the thorax is punctured with a thin knife in an intercostal space
Pregunta 89
Pregunta
Where is the main accumulation of glycogen in patients with diabetes?
Respuesta
-
in epithelial cells of convoluted tubules and Henle’s loop
-
in epithelial cells of gastrointestinal mucosa
-
in the nuclei and in the cytoplasm of the hepatocytes
-
endothelial cells of the vessels
Pregunta 90
Pregunta
The abnormal inclusions in the hepatocytes in alpha-1 antitrypsin deficiency are composed of
Respuesta
-
glycogen
-
lipids
-
bile
-
proteins
Pregunta 91
Pregunta
PAS reaction with PAS control is used to distinguish
Pregunta 92
Pregunta
PAS-control is done using
Respuesta
-
sulfuric acid
-
hydrochloric acid
-
amylase
-
picric acid
Pregunta 93
Pregunta
What is the relation between fatty degeneration of the liver and diabetes?
Respuesta
-
there is no relation between them
-
patients with diabetes have increased intake of lipids to provide more energy
-
the fatty liver in diabetes is caused by increased lipolysis and increased delivery of fatty acids in the liver
-
the fatty liver leads to diabetes mellitus
Pregunta 94
Pregunta
What is android type of obesity?
Respuesta
-
also called “male”or “apple” type, it is the accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female” or “pear’’type, it is the accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Pregunta 95
Pregunta
What is gynoid type of obesity?
Respuesta
-
also called “male”or “apple” type, it is the accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female”or “pear”type, it is the accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Pregunta 96
Pregunta
What is upper type of obesity?
Respuesta
-
also called “male”or “apple” type, accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female”or “pear”type, it is the accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Pregunta 97
Pregunta
What is lower type of obesity?
Respuesta
-
also called “male” or “apple” type, it is the accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female”or “pear”’type - accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Pregunta 98
Pregunta
Which type of obesity has worse prognosis?
Pregunta 99
Pregunta
Haemolytic jaundice is characterized by the following laboratory findings:
Respuesta
-
increased indirect bilirubin in the serum, hypercholic stools and increased urobilinogen in the urine
-
both types of bilirubin are increased in the serum, normal colour of the stools, both bilirubin and urobilinogen are increased in the urine
-
increased direct bilirubin in the serum, hypoholic or acholic stool, increased bilirubin in the urine
-
none of the above
Pregunta 100
Pregunta
Mechanical jaundice is characterized by the following laboratory findings
Respuesta
-
increased indirect bilirubin in the serum, hypercholic stools and increased urobilinogen in the urine
-
both types of bilirubin are increased in the serum, normal colour of the stools, both bilirubin and urobilinogen are increased in the urine
-
increased direct bilirubin in the serum, hypocholic or acholic stools, increased bilirubin in the urine
-
none of the above