17000429
Descripción
Test por Matthew Coulson, actualizado hace más de 1 año
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Creado por Matthew Coulson
hace más de 5 años
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Pregunta 1
Pregunta
Between months 3-7 of pregnancy, the foetus uses which organ to conduct haematopoiesis?
The [blank_start]Spleen[blank_end]
Respuesta
-
Spleen
Pregunta 2
Pregunta
A Multipotent Haematopoietic Stem Cell (Hemocystblast) can differentiate to form two types of common progenitor stem cells:
The Common [blank_start]Myeloid[blank_end] Progenitor, which goes on to form such cells as neutrophils, basophils and erythrocytes.
The Common [blank_start]Lymphoid[blank_end] Progenitor, which goes on to form such cells as natural killer cells, B cells and T cells.
Respuesta
-
Lymphoid
-
Myeloid
Pregunta 3
Pregunta
An erythrocyte is another term for a [blank_start]red blood cell[blank_end].
Erythrocytes arise from Common [blank_start]Myeloid[blank_end] Progenitor Cells
Respuesta
-
Myeloid
-
red blood cell
Pregunta 4
Pregunta
During erythropoiesis, the late normoblast matures by losing which of its internal structures?
Its [blank_start]nucleus[blank_end]
Respuesta
-
nucleus
Pregunta 5
Pregunta
Immature, non-nucleated red blood cells are called [blank_start]reticulocytes[blank_end]
Respuesta
-
reticulocytes
Pregunta 6
Pregunta
A [blank_start]megakaryocyte[blank_end] is a large bone marrow cell with a lobulated nucleus which is responsible for the production of platelets
Respuesta
-
megakaryocyte
Pregunta 7
Pregunta
Megakaryocytes (and thus platelets) arise from common [blank_start]myeloid[blank_end] progenitor cells.
Respuesta
-
myeloid
Pregunta 8
Pregunta
Name the three types of granulocytes in alphabetical order
[blank_start]Basophils[blank_end]
[blank_start]Eosinophils[blank_end]
[blank_start]Neutrophils[blank_end]
Respuesta
-
Basophils
-
Eosinophils
-
Neutrophils
Pregunta 9
Pregunta
[blank_start]Neutrophils[blank_end] - Granulocytes with polymorphic (multiple) nuclei
[blank_start]Eosinophils[blank_end] - Granulocytes with bi-lobed nucleus
[blank_start]Basophils[blank_end] - Granulocytes with large deep purple granules obscuring the nucleus
Respuesta
-
Neutrophils
-
Eosinophils
-
Basophils
-
Eosinophils
-
Neutrophils
-
Basophils
-
Basophils
-
Neutrophils
-
Eosinophils
Pregunta 10
Respuesta
-
Neutrophil
-
Eosinophil
-
Basophil
Pregunta 11
Respuesta
-
Monocyte
Pregunta 12
Pregunta
Monocytes circulate in the blood for around a week before entering tissues to become [blank_start]macrophages[blank_end]
Respuesta
-
macrophages
Pregunta 13
Pregunta
Which bony aspect of the hip is the most common site for bone marrow aspiration?
The [blank_start]posterior iliac crest[blank_end]
Respuesta
-
posterior iliac crest
Pregunta 14
Pregunta
Which aspect of the iliac crests, anterior or posterior, is the most common site for bone marrow aspiration?
The [blank_start]Posterior[blank_end] Iliac Crests
Respuesta
-
Posterior
Pregunta 15
Pregunta
A bone marrow biopsy is also commonly called a [blank_start]trephine[blank_end] biopsy due to the surgical instrument used to conduct the procedure, which has a cylindrical saw used for removing a disk of bone.
Respuesta
-
trephine
Pregunta 16
Pregunta
Red blood cells have large, single nuclei.
Respuesta
- True
- False
Pregunta 17
Pregunta
Adult Haemoglobin consists of two [blank_start]alpha[blank_end] chains and two [blank_start]beta[blank_end] chains
Respuesta
-
alpha
-
delta
-
beta
-
gamma
Pregunta 18
Pregunta
Foetal Haemoglobin consists of two [blank_start]alpha[blank_end] chains and two [blank_start]gamma[blank_end] chains
Respuesta
-
alpha
-
delta
-
gamma
-
beta
Pregunta 19
Pregunta
[blank_start]Gamma[blank_end] chains allow a higher affinity for oxygen as they do not interact as well with 2,3-DPG
Respuesta
-
Gamma
-
Alpha
-
Beta
-
Delta
Pregunta 20
Pregunta
[blank_start]Fe3+[blank_end] = Oxidised form of iron
[blank_start]Fe2+[blank_end] = Reduced (non-oxidised) form of Iron
Respuesta
-
Fe3+
-
Fe2+
-
Fe2+
-
Fe3+
Pregunta 21
Pregunta
The form of iron that exists in the Heme group is the [blank_start]non-oxidised[blank_end] [blank_start]Fe2+[blank_end] form
Respuesta
-
non-oxidised
-
oxidised
-
Fe2+
-
Fe3+
Pregunta 22
Pregunta
Red Blood Cell destruction occurs in which organ?
The [blank_start]Spleen[blank_end]
Respuesta
-
Spleen
Pregunta 23
Pregunta
The heme group of the red blood cell is broken down by the spleen into Iron and [blank_start]Bilirubin[blank_end]
Respuesta
-
Bilirubin
Pregunta 24
Pregunta
Which organ conjugates bilirubin?
The [blank_start]Liver[blank_end]
Respuesta
-
Liver
Pregunta 25
Pregunta
Bilirubin is excreted within which substance, which gives colour to both urine and faeces?
The [blank_start]Bile[blank_end]
Respuesta
-
Bile
Pregunta 26
Pregunta
Heme breakdown pathway:
Heme --> [blank_start]Porphyrin[blank_end] --> [blank_start]Biliverdin[blank_end] --> [blank_start]Unconjugated Bilirubin[blank_end]
Respuesta
-
Porphyrin
-
Biliverdin
-
Unconjugated Bilirubin
Pregunta 27
Pregunta
Which hormone regulates the differentiation and proliferation of erythroid progenitor cells in the bone marrow to mature red blood cells?
[blank_start]Erythropoietin[blank_end]
Respuesta
-
Erythropoietin
Pregunta 28
Pregunta
Erythropoietin is produced mainly in the [blank_start]kidneys[blank_end]
Respuesta
-
kidneys
Pregunta 29
Pregunta
Methemoglobin is the non-oxygen carrying type of haemoglobin in which the heme groups contains the [blank_start]oxidised[blank_end] [blank_start]Fe3+[blank_end]
Respuesta
-
oxidised
-
non-oxidised
-
Fe3+
-
Fe2+
Pregunta 30
Pregunta
Superoxide to Hydrogen Peroxide is regulated by which enzyme?
[blank_start]Superoxide Dismutase[blank_end]
Respuesta
-
Superoxide Dismutase
Pregunta 31
Pregunta
Which antioxidant reacts with Hydrogen Peroxide to form water, in order to protect us against the free radical?
[blank_start]Glutathione[blank_end]
Respuesta
-
Glutathione
Pregunta 32
Pregunta
CO2 Transport:
10% [blank_start]Dissolved in solution[blank_end]
30% [blank_start]Bound directly to Hb[blank_end]
60% [blank_start]Travels as Bicarbonate[blank_end]
Respuesta
-
Travels as Bicarbonate
-
Bound directly to Hb
-
Dissolved in solution
Pregunta 33
Pregunta
[blank_start]Myoglobin[blank_end] follows Michaelis-Menten Kinetics
[blank_start]Haemoglobin[blank_end] DOES NOT follow Michaelis-Menten Kinetics
Respuesta
-
Haemoglobin
-
Myoglobin
-
Myoglobin
-
Haemoglobin
Pregunta 34
Pregunta
The product of the Rapapoport-Lubering Shunt is ...
Respuesta
-
2,3-DPG
-
Glutathione
-
Pentose Phosphate
-
Hexose Monophosphate
-
Glyceraldehyde-3-Phosphate
Pregunta 35
Pregunta
As 2,3-DPG concentration increases, the rate of oxygen dissociation [blank_start]increases[blank_end] as the affinity of haemoglobin for oxygen [blank_start]decreases[blank_end].
Respuesta
-
decreases
-
increases
-
increases
-
decreases
Pregunta 36
Pregunta
The causes of a right shift to the Oxygen–hemoglobin dissociation curve:
[blank_start]Increase[blank_end] in CO2 concentration
[blank_start]Decrease[blank_end] in pH
[blank_start]Increase[blank_end] in 2,3-DPG concentration
[blank_start]Increase[blank_end] in Exercise
[blank_start]Increase[blank_end] in Temperature
Respuesta
-
Increase
-
Decrease
-
Decrease
-
Increase
-
Increase
-
Decrease
-
Increase
-
Decrease
-
Increase
-
Decrease
Pregunta 37
Pregunta
Glutathione is replenished by which chemical? Hint: It is a normal part of glycolysis
[blank_start]NADPH[blank_end]
Respuesta
-
NADPH
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