17078545
Descripción
Test por Matthew Coulson, actualizado hace más de 1 año
|
Creado por Matthew Coulson
hace más de 5 años
|
|
Pregunta 1
Pregunta
Major forms of Hb:
HbA = 2 Alpha chains & 2 [blank_start]Beta[blank_end] chains
HbA2 = 2 Alpha chains & 2 [blank_start]Delta[blank_end] chains
HbF = 2 Alpha chains & 2 [blank_start]Gamma[blank_end] chains
Respuesta
-
Beta
-
Delta
-
Gamma
-
Delta
-
Beta
-
Gamma
-
Theta
-
Gamma
-
Delta
-
Beta
-
Theta
-
Theta
Pregunta 2
Pregunta
The most abundant Hb in the normal human body is [blank_start]HbA[blank_end]
Respuesta
-
HbA
-
HbA2
-
HbF
Pregunta 3
Pregunta
Alpha genes lie on chromosome 16. There are [blank_start]4[blank_end] alpha genes per cell ([blank_start]2[blank_end] on each chromosome)
Beta genes lie on chromosome 11. There are [blank_start]2[blank_end] beta genes per cell ([blank_start]1[blank_end] on each chromosome)
Respuesta
-
4
-
2
-
6
-
2
-
1
-
3
-
2
-
4
-
6
-
1
-
2
-
3
Pregunta 4
Pregunta
Adult levels of HbA are typically achieved by [blank_start]12 months[blank_end] of age
Respuesta
-
12 months
-
3 months
-
18 months
-
2 years
Pregunta 5
Pregunta
Haemoglobinopathies are hereditary conditions which affect the synthesis of [blank_start]globin[blank_end] chains, thus affecting haemoglobin production.
Respuesta
-
globin
Pregunta 6
Pregunta
Haemoglobinopathies whereby there is a decreased rate of globin chain synthesis are called [blank_start]thalassaemias[blank_end]
Respuesta
-
thalassaemias
Pregunta 7
Pregunta
Reduced rate of production of alpha globin chains is known as [blank_start]alpha thalassaemia[blank_end]
Reduced rate of production of beta globin chains is known as [blank_start]beta thalassaemia[blank_end]
Respuesta
-
alpha thalassaemia
-
beta thalassaemia
Pregunta 8
Pregunta
Thalassaemias lead to [blank_start]microcytic[blank_end] anaemia
Respuesta
-
microcytic
-
macrocytic
Pregunta 9
Pregunta
[blank_start]Alpha Thalassaemia Trait[blank_end] = 1 or 2 alpha genes missing (i.e -α/αα OR -α/-α)
[blank_start]Haemoglobin H Disease (HbH)[blank_end] = 3 alpha genes missing (i.e. (--/-α)
[blank_start]Barts Hydrops Fetalis[blank_end] = All 4 alpha genes missing (i.e. (--/--)
Respuesta
-
Barts Hydrops Fetalis
-
Haemoglobin H Disease (HbH)
-
Alpha Thalassaemia Trait
Pregunta 10
Pregunta
Alpha Thalassaemia Trait is the most severe form of the condition and patients rarely survive past infancy.
Respuesta
- True
- False
Pregunta 11
Pregunta
HbH disease causes strange 3 beta 1 alpha tetramers to form which can't carry oxygen, thus causing severe anaemia.
Respuesta
- True
- False
Pregunta 12
Pregunta
The skin of HbH Disease patient may be slightly discoloured as this condition is known to cause a mild [blank_start]jaundice[blank_end]
Respuesta
-
jaundice
Pregunta 13
Pregunta
Extramedullary haematopoiesis in HbH Disease causes the pathological enlargement of which organ?
The [blank_start]Spleen[blank_end]
Respuesta
-
Spleen
Pregunta 14
Pregunta
Hb Barts Hydrops Fetalis is a condition whereby HbA cannot be produced due to the inability to synthesize alpha chains. This condition is typically incompatible with life.
Respuesta
- True
- False
Pregunta 15
Pregunta
[blank_start]Alpha[blank_end] Thalassaemia is considered to be more dangerous that [blank_start]Beta[blank_end] Thalassaemia as the former affects HbA, HbA2 & HbF whereas the latter only affects HbA
Respuesta
-
Beta
-
Alpha
-
Alpha
-
Beta
Pregunta 16
Pregunta
β+/β or β0/β = Beta Thalassaemia [blank_start]Trait[blank_end]
β+/β+ or β0/β+ = Beta Thalassaemia [blank_start]Intermedia[blank_end]
β0/β0 = Beta Thalassaemia [blank_start]Major[blank_end]
Respuesta
-
Trait
-
Intermedia
-
Major
Pregunta 17
Pregunta
Beta Thalassaemia Trait = [blank_start]Asymptomatic[blank_end]
Beta Thalassaemia Intermedia = [blank_start]Occasional Transfusions Required[blank_end]
Beta Thalassaemia Major = [blank_start]Lifelong Transfusions Required[blank_end]
Respuesta
-
Asymptomatic
-
Occasional Transfusions Required
-
Lifelong Transfusions Required
Pregunta 18
Pregunta
Beta thalassaemia major present around 6-24 months of age as the individual's [blank_start]HbF[blank_end] falls
Respuesta
-
HbF
-
HbA
-
HbA2
Pregunta 19
Pregunta
Children with beta thalassaemia major will typically present with which two key clinical signs?
Respuesta
-
Pallor
-
Failure to thrive
-
Reduced consciousness
-
Reduced appetite
-
Loss of accommodation reflex
Pregunta 20
Pregunta
Beta thalassaemia major can be separated from Alpha thalassaemia by looking at the child's blood - there will be an abundance of HbF in young beta thalassaemia patients.
Respuesta
- True
- False
Pregunta 21
Pregunta
Regular transfusion of patients with beta thalassaemia major aims to keep the Hb level at around [blank_start]95-105[blank_end]g/L
Respuesta
-
95-105
-
105-15
-
115-125
Pregunta 22
Pregunta
The main cause of mortality in beta thalassaemia major patients who are well treated is [blank_start]iron[blank_end] overload from the regular blood transfusions
Respuesta
-
iron
Pregunta 23
Pregunta
Beta thalassaemia major patient with iron overload are typically treated via venesection
Respuesta
- True
- False
Pregunta 24
Pregunta
Sickle cell disease is caused by a [blank_start]point[blank_end] mutation in codon 6 of the [blank_start]beta[blank_end] globin gene that substitutes glutamine to value producing Beta Globin S
Respuesta
-
beta
-
point
Pregunta 25
Pregunta
When you have one normal (B) and one abnormal (BS) gene this is known as sickle [blank_start]trait[blank_end]. This is asymptomatic and makes you a carrier of sickle cell disease (not affected by the condition).
Respuesta
-
trait
Pregunta 26
Pregunta
Sickle cell anaemia follows which kind of inheritance pattern?
Autosomal [blank_start]Recessive[blank_end].
Respuesta
-
Recessive
Pregunta 27
Pregunta
Sickle Cell Anaemia causes [blank_start]Hyposplenism[blank_end] due to repeated splenic infarcts
Respuesta
-
Hyposplenism
-
Hypersplenism
Pregunta 28
Pregunta
A patient with known HbSS is out with friends hiking. He progressively develops chest pain, shortness of breath, headache and skin pallor. He is likely experiencing a [blank_start]sickle crisis[blank_end]
Respuesta
-
sickle crisis
Pregunta 29
Pregunta
Sickle cells can become stuck in arteries leading to sickle vaso-occlusion. This can cause a patient extreme [blank_start]pain[blank_end]
Respuesta
-
pain
-
dizziness
-
itchiness
-
nausea
Pregunta 30
Pregunta
Which of the following are common causes of sickle crises in HbSS patients?
Respuesta
-
Hypoxia
-
Dehydration
-
Infection
-
Stress
-
Cold Exposure
Pregunta 31
Pregunta
A Sickle Crisis should be managed by providing analgesia (if pain present, which it likely will be), hydration, oxygen and rest.
Respuesta
- True
- False
Pregunta 32
Pregunta
Long term management of Sickle Cell Disease includes:
- [blank_start]Folic Acid[blank_end] supplementation to increase RBC turnover
- Hydroxycarbamide to induce produce of [blank_start]HbF[blank_end]
Respuesta
-
HbF
-
HbA
-
HbA2
-
Folic Acid (Vitamin B9)
-
Vitamin B12
-
Vitamin A
Pregunta 33
Pregunta
Due to the risk of occlusion, sickle cell anaemia patients are at a significantly higher risk of experiencing a stroke.
Respuesta
- True
- False
Pregunta 34
Pregunta
Raised HbA2 is diagnostic of which type of Thalassaemia?
[blank_start]Beta Thalassaemia Trait[blank_end]
Respuesta
-
Beta Thalassaemia Trait
-
Alpha Thalassaemia Trait
-
HbH Disease
-
Barts Hydrops Fetalis
Pregunta 35
Pregunta
HPLC blood testing is normal in [blank_start]alpha[blank_end] thalassaemia trait and thus DNA testing is necessary to confirm the condition.
Respuesta
-
alpha
-
beta
¿Quieres crear tus propios Tests gratis con GoConqr? Más información.