Pregunta 1
Pregunta
Which of the following is not a pattern of cell death in tissues?
Respuesta
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fibrinoid necrosis
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fat necrosis
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coagulative necrosis
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contracture necrosis
Pregunta 2
Pregunta
Compare acute cell injury with cellular adaptations.
Respuesta
-
Cellular adaptations develop over a brief period of time and are reversible
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Acute cell injury can be manifested as reversible cell swelling
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Acute cell injury can be manifested as irreversible necrosis
Pregunta 3
Pregunta
What is lipofuscin?
Respuesta
-
Blue-pigmented cytoplasmic inclusions in stressed cells
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A lipid-containing residual body of autophagy
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An irreversible "wear and tear" pigment
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A product of cells undergoing decreased cell turnover
Pregunta 4
Pregunta
Metatstatic calcification is due to precipitation of calcium at sites of cell/tissue injury
Pregunta 5
Pregunta
Which of the following mechanisms explains the pathogenesis of alcohol-induced fatty liver?
Respuesta
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Increased delivery of free fatty acids
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Increased lipogenesis
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Decreased apoprotein synthesis for triglyceride export
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Increased utilization of triglycerides and oxidation of fatty acids
Pregunta 6
Pregunta
Metaplasia can be characterized by which of the following?
Respuesta
-
One adult cell type being replaced by another through chronic injury
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Irreversible change in cells/tissue
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Decreased risk of malignancy/neoplasia
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Increase in cell number
Pregunta 7
Pregunta
Which is an example of physiologic apoptosis?
Pregunta 8
Pregunta
Apoptosis can result from endogenous OR exogenous causes
Pregunta 9
Pregunta
In a Masson Trichrome stain
Respuesta
-
Nucleic acids stain dark blue
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Connective tissue stains blue
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Proteins stain light purple
Pregunta 10
Pregunta
Which of the following would you expect to see in necrosis?
Respuesta
-
A rounded up, fragmented cell morphology
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Phagocytosis by neutrophils
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Phagocytosis by macrophages and nonprofessional macrophages
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Functionally intact cell membrane
Pregunta 11
Pregunta
You are examining the tissue of a patient who had a subarachnoid hemorrhage. When looking at the brain tissue microscopically, what would you expect to observe in the area of hemorrhage?
Pregunta 12
Pregunta
At what point in cell injury would you expect to observe hydropic change of the cell?
Respuesta
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< 10 minutes
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10-15 minutes
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15-60 minutes
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4-8 hours
Pregunta 13
Pregunta
You know that irreversible cell injury is often characterized by nuclear changes. Which of the nuclear changes describes pyknosis?
Respuesta
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Fragmentation of the nucleus into dense basophilic fragments ("nuclear debris")
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Dissolution of nuclear fragments
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Condensation of chromatin
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Dilation of the endoplasmic reticulum
Pregunta 14
Pregunta
In coagulative necrosis, the shapes of cells and tissues change dramatically, but the nuclei/organelles are intact.
Pregunta 15
Pregunta
Where would you expect to see liquefactive necrosis most often?
Respuesta
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Brain
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Lungs
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Abscesses
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GI tract
Pregunta 16
Pregunta
Your patient's cells and tissues demonstrate obvious enzymatic necrosis. You immediately know the condition that (likely) caused this is:
Respuesta
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COVID
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Acute pancreatitis
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Myocardial infarction
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Hypercalcemia
Pregunta 17
Pregunta
What is the most common cause of caseous necrosis?
Pregunta 18
Pregunta
Fibrinoid necrosis is caused by injury to vessel walls that causes leakage of protein and fibrin from the circulation that becomes entrapped. Which vascular injury might cause this type of necrosis?
Pregunta 19
Pregunta
What is a heterophagosome?
Respuesta
-
A secondary lysosome involved in digestion of a cell's own organelles
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A primary lysosome fused with absorptive vesicles originating from the plasma membrane
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A small vesicle budding from enzymes on the lateral side of the Golgi apparatus
Pregunta 20
Pregunta
In your elective oncology rotation, a patient presents with multiple calcified breast tumors. You know this to be a result of metastatic calcification.
Pregunta 21
Pregunta
Upon histological examination, tissue cells demonstrate what looks like "nuclear dust". This is characteristic of
Respuesta
-
karyorrhexis
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karyolysis
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karyogram
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pyknosis
Pregunta 22
Pregunta
In response to [blank_start]cigarette smoke[blank_end], columnar epithelial cells of the bronchial epithelium undergo squamous [blank_start]metaplasia[blank_end]. Smoking-induced metaplasia may lead to bronchial squamous cell [blank_start]neoplasia[blank_end].
Respuesta
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cigarette smoke
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sitting for 12 hours/day
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drinking too much water
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pulmonary HTN
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metaplasia
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hyperplasia
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neoplasia