Pregunta 1
Pregunta
Which form of Glycogen Phosphorylase is relatively inactive?
Respuesta
-
Phosphorylase A
-
Phosphorylase B
Pregunta 2
Pregunta
In phosphorylase B, where is the N terminus?
Pregunta 3
Pregunta
Which of the forms of glyocgen phosphorylase is most effected by cellular AMP/ATP levels?
Respuesta
-
Phosphorylase A
-
Phosphorylase B
Pregunta 4
Pregunta
Which of the following phosphorylates Glycogen Phosphorylase?
Respuesta
-
Phosphorylase B Kinase
-
Phosphorylase A Kinase
-
Phosphorylase Kinase
Pregunta 5
Pregunta
What protein causes the dephosphorylation of phosphorylase?
Respuesta
-
Protein phosphatase
-
Protein phosphorylase
-
Prokein Kinase P
Pregunta 6
Pregunta
What is needed for the reaction of Phosphorylase B --> A to reverse itself?
Respuesta
-
Water (and a lack of inhibiting AMP)
-
Water (and a lack of inhibiting ATP)
-
Water (and a lack of inhibiting GMP)
Pregunta 7
Pregunta
What is different about Phosphorylase A to B?
Respuesta
-
Ser14 has been phosphorylated
-
Tyr14 has been phosphorylated
-
Thr14 has been phosphorylated
Pregunta 8
Pregunta
What difference does phosphorylating Glycogen phosphorylase make?
Pregunta 9
Pregunta
How does phosphorylase B Kinase connect Glycogen Phosphorylase levels to the level of stimulation?
Respuesta
-
It is activated by Ca2+- when the muscle is stimulated, glucose is needed and so glycogen is broken down
-
It is deactivated by Ca2+- when the muscle is stimulated, glucose is not needed and so glycogen isn't broken down
Pregunta 10
Pregunta
What part of Phosphorylase B Kinase binds to Calcium?
Respuesta
-
Calmodulin
-
Calsequestrin
-
Troponin C
Pregunta 11
Pregunta
Which parts of phosphorylase B kinase are regulatory?
Respuesta
-
Alpha and beta
-
Alpha and gamma
-
Gamma and beta
Pregunta 12
Pregunta
Which part of phosphorylase B kinase is catalytic?
Pregunta 13
Pregunta
In phosphorylase B kinase's Ca2+ binding sites, what are the affinities?
Respuesta
-
2 high
2 low
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4 high
-
4 low
Pregunta 14
Pregunta
What protein causes the phosphorylation of Phosphorylase B Kinase?
Pregunta 15
Pregunta
What is another name of cAMP dependent protein kinase?
Respuesta
-
Protein Kinase A
-
Protein Kinase B
-
Protein Kinase C
Pregunta 16
Pregunta
What is the role of inhibitor one?
Respuesta
-
To bind to protein phosphatase, activating it
-
To bind to protein phosphatase, inhibiting it
-
To bind to protein kinase A, activating it
Pregunta 17
Pregunta
What is contained in the N terminus domain of Glycogen Phosphorylase?
Pregunta 18
Pregunta
How does glycogen get from it's binding domain to the catalytic site?
Respuesta
-
A hydrophobic tunnel
-
A hydrophillic tunnel
-
A lipophobic tunnel
Pregunta 19
Pregunta
Why is glycogen phosphorylase's site in a deep groove?
Respuesta
-
To prevent AMP from entering
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To prevent ATP from entering
-
To prevent water from entering
Pregunta 20
Pregunta
What happens if water enters the active site?