transplant and reproductive immunology

Descripción

Medicine Test sobre transplant and reproductive immunology, creado por mariam Butt el 07/07/2021.
mariam Butt
Test por mariam Butt, actualizado hace más de 1 año
mariam Butt
Creado por mariam Butt hace más de 3 años
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Resumen del Recurso

Pregunta 1

Pregunta
The graft is a graft from 1 place to another in the same individual
Respuesta
  • right
  • wrong

Pregunta 2

Pregunta
Should blood group compatibility between donor and recipient be determined before kidney transplantation
Respuesta
  • yes
  • no

Pregunta 3

Pregunta
3. Classical MHC class II antigens (HLA-DR, DQ) have a more limited distribution than MHC class I antigens
Respuesta
  • yes
  • no

Pregunta 4

Pregunta
4. The most suitable cells for HLA compatibility testing are lymphocytes derived from the patient's peripheral blood
Respuesta
  • yes
  • no

Pregunta 5

Pregunta
After blood transfusions, pregnancy and previous transplants can form circulating antibodies
Respuesta
  • yes
  • no

Pregunta 6

Pregunta
The acute rejection reaction of the transplanted organ is manifested:
Respuesta
  • 3 years
  • 5-6 months
  • up to 3 months
  • up to 1-2 weeks

Pregunta 7

Pregunta
Rejection of the transplant is a manifestation of
Respuesta
  • Cell-mediated immunity
  • An important process in allograft rejection is humoral-mediated immunity
  • Hypersensitivity of type 3 (immune complexes)
  • Complement-dependent cytotoxicity
  • can damage the graft through its prancreatic enzymes.
  • The immune response to the allograft may also include antibodies- igD

Pregunta 8

Pregunta
Graft reaction against the host (GVH)
Respuesta
  • -It manifests itself in different MHC antigens between donor and recipient
  • GVH response does require suppressor T cells
  • -May be the result of an infusion of blood products containing viable lymphocytes into immunologically incompetent recipient
  • (GVH) is caused by the destruction of cells or tissues of immunocompetent recipient of immunocompetent stem cells

Pregunta 9

Pregunta
During transplantation, the preformed cytotoxic antibodies in the recipient
Respuesta
  • Are responsible for the super-sharp rejection
  • Cytotoxic antibodies of class IgA and IgD lead to an over-acute rejection reaction
  • Can be directed against HLA or ABO antigens of the graft
  • all are correct

Pregunta 10

Pregunta
Immunological follow-up of an organ transplant patient requires examination of
Respuesta
  • Changes in lymphocyte populations and subpopulations
  • n acute rejection is dominated by CD3 + T lymphocytes
  • Donor-specific AT
  • Serum levels of cytokines
  • serum levels of interferons

Pregunta 11

Pregunta
In recipients with repeated kidney transplants, graft survival compared to that in recipients with a first kidney transplant is:
Respuesta
  • reduced
  • increased
  • recurrent antigenic incompatibilities (especially DR) between donor and recipient in repeated kidney transplants have a positive effect on graft survival.

Pregunta 12

Pregunta
Prevention of hemolytic disease of the newborn due to compatibility with maternal Rhesus (RhD) factor includes
Respuesta
  • passive maternal immunization to remove Rh antigen
  • active maternal immunization to remove Rh antigen
  • infusion done after 72hours after the first birth
  • infusion of anti-RhD antibodies to the Rh (+) mother

Pregunta 13

Pregunta
If the mother develops IgG AT to A and B erythrocyte antigens of the fetus, hemolytic disease of the newborn will appear in children from:
Respuesta
  • - 0 mother and AB father
  • AB mother and 0 father
  • A mother and ab father
  • 0 mother and A father

Pregunta 14

Pregunta
Which of the following AGs are rich in cell membranes of B-lymphocytes
Respuesta
  • MHC class II antigens
  • MHC class I antigens
  • all are correct
  • none are correct

Pregunta 15

Pregunta
Class III MHC regions in the major human tissue compatibility complex contain genes which encode
Respuesta
  • - components of the complement system
  • heat shock proteins and cytokines
  • none are correct
  • components of cellular immunity

Pregunta 16

Pregunta
Antimetabolites that suppress the immune response are the purine antagonists are
Respuesta
  • involved in dna synthesis
  • mercapturin
  • azathioprine
  • involved in mRna synthesis

Pregunta 17

Pregunta
Hypersensitivity graft rejection is associated with
Respuesta
  • preformed cytotoxic antibodies
  • complement activation
  • cellular immunity
  • nantural resistance

Pregunta 18

Pregunta
The accelerated rejection reaction involves the following immunological factors and mechanisms of
Respuesta
  • sensitized T cells preformed by HLA AT formed during immune response to graft or AZKC
  • activated b cells
  • complement system
  • all are correct

Pregunta 19

Pregunta
Molecular genetic methods for HLA typing in clinical transplant practice include
Respuesta
  • elisa
  • electrophoresis
  • immunoblot
  • pcr

Pregunta 20

Pregunta
The cells infiltrating the graft in the acute rejection reaction are predominantly
Respuesta
  • CD4 +
  • CD3 +
  • CD16 +
  • CD8+

Pregunta 21

Pregunta
Allogeneic transplantation
Respuesta
  • bone marrow transplantation from mother to daughter
  • bone marrow transplantation from daughter to mother
  • bone marrow transplantation from mother to son
  • bone marrow transplantation from father to daughter

Pregunta 22

Pregunta
Autologous transplantation
Respuesta
  • transplantation of skin from the thigh to the face of the same individual
  • transplantation of skin from the thigh to the face of the different individual
  • transplantation of skin from the thigh of a twin to the face of the other twin individual
  • done to replace cicatrix for cosmetic procedure

Pregunta 23

Pregunta
Syngenna
Respuesta
  • bone marrow transplantation from same individual
  • bone marrow transplantation between twins
  • bone marrow transplantation between family members
  • bone marrow transplantation between two compatible donor and recipient

Pregunta 24

Pregunta
Sources of stem cells
Respuesta
  • serum
  • peripheral blood
  • pancreas
  • umbilical cord
  • bone marrow
  • epiphysis

Pregunta 25

Pregunta
Gene loci of the HLA-class II region (3 correct)
Respuesta
  • dp
  • rt
  • dq
  • dr
  • ds
  • located in the long arm of the sixth chromosome in humans

Pregunta 26

Pregunta
Hormones: luteinizing (LH), follicle-stimulating (FSH), inhibin B and estradiol, are tested in serum to assess ovarian reserve in women with reproductive disorders
Respuesta
  • yes
  • no

Pregunta 27

Pregunta
Recurrent abortions are not associated with defects in coagulation factors or circulating anticoagulants (lupus-like anticoagulants)
Respuesta
  • correct
  • incorrect

Pregunta 28

Pregunta
Women with positive anti-ovarian antibodies have an increased chance of becoming pregnant after birth control in vitro fertilization or embryo transfer compared to women in whom no such was found antibodies
Respuesta
  • no
  • yes

Pregunta 29

Pregunta
Antibodies in women with reproductive disorders are tested by serum
Respuesta
  • yes
  • no

Pregunta 30

Pregunta
Antiphospholipid syndrome is associated with the presence of anticardiolipin antibodies, loss of fetal, arterial and venous thrombosis
Respuesta
  • no
  • yes

Pregunta 31

Pregunta
which hormone is secreted by the granulosa cells of the ovary and controls the series of follicle-stimulating hormone from the pituitary gland
Respuesta
  • fsh
  • lh
  • inhibin b
  • estradiol

Pregunta 32

Pregunta
Which immune indicators are associated with premature decline in ovarian function
Respuesta
  • rbc,wbc,anti-dna
  • ca19-9, anti phospholipid,antithyroid
  • - antiphospholipid, antinuclear, antithyroid and anti-ovarian AT
  • none of the above

Pregunta 33

Pregunta
The study of the reproductive immunophenotype in women with reproductive problems includes
Respuesta
  • T-lymphocytes CD3 +, CD4 +, CD8 +
  • B-lymphocytes CD19 +
  • NK cells CD3 CD56 +, CD16 +

Pregunta 34

Pregunta
Immunological manifestations in patients with endometriosis and reproductive problems are demonstrated
Respuesta
  • increased serum levels of antiphospholipid and antinuclear antibodies
  • activated reproductive phenotype and increased NK-cell cytotoxicity
  • increase in CA125

Pregunta 35

Pregunta
In patients with previous abortions, monitoring and prognosis of the current pregnancy includes a study of serum concentrations of
Respuesta
  • FSH
  • - beta human chorionic gonadotropin
  • LH
  • pituitary gland

Pregunta 36

Pregunta
HLA-G antigens are expressed in
Respuesta
  • myoblast
  • osteoblasts
  • trophoblasts
  • lymphokines

Pregunta 37

Pregunta
The main functions of HLA-G antigens are (SPECIFY THE WRONG ANSWER)
Respuesta
  • inhibiting the antitrophoblast activity of maternal NK cells
  • protecting the fetus from the mother's immune response against the paternal antigens in it
  • inducing frequent abortions
  • protection of the fetus from transplant infections

Pregunta 38

Pregunta
Elevated NK cells in women with frequent abortions (SPECIFY THE WRONG ANSWER)
Respuesta
  • secrete tumor necrosis factor (TNF)
  • are examined by peripheral venous blood in an anticoagulant
  • are cytotoxic to the placental trophoblast
  • they don't matter

Pregunta 39

Pregunta
The immunological examination of anti-phospholipid syndrome in pregnant women includes
Respuesta
  • - anticardiolipin antibodies
  • -antibodies to phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, phosphatidylglycerol, phosphatidylserine, phosphatidylcholine
  • anti-beta-2-glycoprotein I AT

Pregunta 40

Pregunta
Anti-ovarian antibodies include AT versus (2 correct)
Respuesta
  • antigens of the pellucid zone
  • antigens of steroid-producing granulosa-luteinizing cells
  • Antibodies against the pellucid zone are also important in specifying cases of cervical cancer
  • Antibodies against the pellucid zone are also important in specifying cases of cystic disease.

Pregunta 41

Pregunta
The normal development of pregnancy is due to the predominance of
Respuesta
  • Th1 cytokines
  • Th2 cytokines
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