Pregunta 1
Pregunta
The graft is a graft from 1 place to another in the same individual
Pregunta 2
Pregunta
Should blood group compatibility between donor and recipient be determined before kidney transplantation
Pregunta 3
Pregunta
3. Classical MHC class II antigens (HLA-DR, DQ) have a more limited distribution than MHC class I antigens
Pregunta 4
Pregunta
4. The most suitable cells for HLA compatibility testing are lymphocytes derived from the patient's peripheral blood
Pregunta 5
Pregunta
After blood transfusions, pregnancy and previous transplants can form
circulating antibodies
Pregunta 6
Pregunta
The acute rejection reaction of the transplanted organ is manifested:
Respuesta
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3 years
-
5-6 months
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up to 3 months
-
up to 1-2 weeks
Pregunta 7
Pregunta
Rejection of the transplant is a manifestation of
Respuesta
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Cell-mediated immunity
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An important process in allograft rejection is humoral-mediated immunity
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Hypersensitivity of type 3 (immune complexes)
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Complement-dependent cytotoxicity
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can damage the graft through its prancreatic enzymes.
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The immune response to the allograft may also include antibodies- igD
Pregunta 8
Pregunta
Graft reaction against the host (GVH)
Respuesta
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-It manifests itself in different MHC antigens between donor and recipient
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GVH response does require suppressor T cells
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-May be the result of an infusion of blood products containing viable lymphocytes into
immunologically incompetent recipient
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(GVH) is caused by the destruction of cells or tissues of
immunocompetent recipient of immunocompetent stem cells
Pregunta 9
Pregunta
During transplantation, the preformed cytotoxic antibodies in the recipient
Respuesta
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Are responsible for the super-sharp rejection
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Cytotoxic antibodies of class IgA and IgD lead to an over-acute rejection reaction
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Can be directed against HLA or ABO antigens of the graft
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all are correct
Pregunta 10
Pregunta
Immunological follow-up of an organ transplant patient requires examination of
Respuesta
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Changes in lymphocyte populations and subpopulations
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n acute rejection is dominated by CD3 + T lymphocytes
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Donor-specific AT
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Serum levels of cytokines
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serum levels of interferons
Pregunta 11
Pregunta
In recipients with repeated kidney transplants, graft survival compared to
that in recipients with a first kidney transplant is:
Pregunta 12
Pregunta
Prevention of hemolytic disease of the newborn due to compatibility with maternal Rhesus (RhD) factor includes
Respuesta
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passive maternal immunization to remove Rh antigen
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active maternal immunization to remove Rh antigen
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infusion done after 72hours after the first birth
-
infusion of anti-RhD antibodies to the Rh (+) mother
Pregunta 13
Pregunta
If the mother develops IgG AT to A and B erythrocyte antigens of the fetus, hemolytic disease of the newborn will appear in children from:
Respuesta
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- 0 mother and AB father
-
AB mother and 0 father
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A mother and ab father
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0 mother and A father
Pregunta 14
Pregunta
Which of the following AGs are rich in cell membranes of B-lymphocytes
Respuesta
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MHC class II antigens
-
MHC class I antigens
-
all are correct
-
none are correct
Pregunta 15
Pregunta
Class III MHC regions in the major human tissue compatibility complex contain genes which encode
Respuesta
-
- components of the complement system
-
heat shock proteins and cytokines
-
none are correct
-
components of cellular immunity
Pregunta 16
Pregunta
Antimetabolites that suppress the immune response are the purine antagonists are
Pregunta 17
Pregunta
Hypersensitivity graft rejection is associated with
Pregunta 18
Pregunta
The accelerated rejection reaction involves the following immunological factors and
mechanisms of
Pregunta 19
Pregunta
Molecular genetic methods for HLA typing in clinical transplant practice
include
Respuesta
-
elisa
-
electrophoresis
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immunoblot
-
pcr
Pregunta 20
Pregunta
The cells infiltrating the graft in the acute rejection reaction are predominantly
Pregunta 21
Pregunta
Allogeneic transplantation
Respuesta
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bone marrow transplantation from mother to daughter
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bone marrow transplantation from daughter to mother
-
bone marrow transplantation from mother to son
-
bone marrow transplantation from father to daughter
Pregunta 22
Pregunta
Autologous transplantation
Respuesta
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transplantation of skin from the thigh to the face of the same individual
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transplantation of skin from the thigh to the face of the different individual
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transplantation of skin from the thigh of a twin to the face of the other twin individual
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done to replace cicatrix for cosmetic procedure
Pregunta 23
Respuesta
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bone marrow transplantation from same individual
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bone marrow transplantation between twins
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bone marrow transplantation between family members
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bone marrow transplantation between two compatible donor and recipient
Pregunta 24
Pregunta
Sources of stem cells
Respuesta
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serum
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peripheral blood
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pancreas
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umbilical cord
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bone marrow
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epiphysis
Pregunta 25
Pregunta
Gene loci of the HLA-class II region (3 correct)
Pregunta 26
Pregunta
Hormones: luteinizing (LH), follicle-stimulating (FSH), inhibin B and estradiol, are tested in serum to assess ovarian reserve in women with reproductive disorders
Pregunta 27
Pregunta
Recurrent abortions are not associated with defects in coagulation factors or circulating anticoagulants (lupus-like anticoagulants)
Pregunta 28
Pregunta
Women with positive anti-ovarian antibodies have an increased chance of becoming pregnant
after birth control in vitro fertilization or embryo transfer compared to women in whom no such was found antibodies
Pregunta 29
Pregunta
Antibodies in women with reproductive disorders are tested by serum
Pregunta 30
Pregunta
Antiphospholipid syndrome is associated with the presence of anticardiolipin antibodies, loss of
fetal, arterial and venous thrombosis
Pregunta 31
Pregunta
which hormone is secreted by the granulosa cells of the ovary and controls the series of
follicle-stimulating hormone from the pituitary gland
Respuesta
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fsh
-
lh
-
inhibin b
-
estradiol
Pregunta 32
Pregunta
Which immune indicators are associated with premature decline in ovarian function
Respuesta
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rbc,wbc,anti-dna
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ca19-9, anti phospholipid,antithyroid
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- antiphospholipid, antinuclear, antithyroid and anti-ovarian AT
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none of the above
Pregunta 33
Pregunta
The study of the reproductive immunophenotype in women with reproductive problems includes
Respuesta
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T-lymphocytes CD3 +, CD4 +, CD8 +
-
B-lymphocytes CD19 +
-
NK cells CD3 CD56 +, CD16 +
Pregunta 34
Pregunta
Immunological manifestations in patients with endometriosis and reproductive problems are
demonstrated
Pregunta 35
Pregunta
In patients with previous abortions, monitoring and prognosis of the current
pregnancy includes a study of serum concentrations of
Pregunta 36
Pregunta
HLA-G antigens are expressed in
Respuesta
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myoblast
-
osteoblasts
-
trophoblasts
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lymphokines
Pregunta 37
Pregunta
The main functions of HLA-G antigens are (SPECIFY THE WRONG ANSWER)
Respuesta
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inhibiting the antitrophoblast activity of maternal NK cells
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protecting the fetus from the mother's immune response against the paternal antigens in it
-
inducing frequent abortions
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protection of the fetus from transplant infections
Pregunta 38
Pregunta
Elevated NK cells in women with frequent abortions (SPECIFY THE WRONG ANSWER)
Respuesta
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secrete tumor necrosis factor (TNF)
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are examined by peripheral venous blood in an anticoagulant
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are cytotoxic to the placental trophoblast
-
they don't matter
Pregunta 39
Pregunta
The immunological examination of anti-phospholipid syndrome in pregnant women includes
Respuesta
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- anticardiolipin antibodies
-
-antibodies to phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, phosphatidylglycerol, phosphatidylserine, phosphatidylcholine
-
anti-beta-2-glycoprotein I AT
Pregunta 40
Pregunta
Anti-ovarian antibodies include AT versus (2 correct)
Respuesta
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antigens of the pellucid zone
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antigens of steroid-producing granulosa-luteinizing cells
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Antibodies against the pellucid zone are also important in specifying
cases of cervical cancer
-
Antibodies against the pellucid zone are also important in specifying
cases of cystic disease.
Pregunta 41
Pregunta
The normal development of pregnancy is due to the predominance of
Respuesta
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Th1 cytokines
-
Th2 cytokines