Alpha 1 Adrenergic Receptor Pathway

Descripción

Year 2 Test sobre Alpha 1 Adrenergic Receptor Pathway, creado por gina_evans0312 el 03/11/2013.
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Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312 hace alrededor de 11 años
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Resumen del Recurso

Pregunta 1

Pregunta
Which Gprotein causes the activation Phospholipase CBeta?
Respuesta
  • Gq
  • Gs
  • Gi

Pregunta 2

Pregunta
How is Phospholipase CBeta activated?
Respuesta
  • By GTP binding to the alpha subunit of the Gq protein
  • By ATP binding to the alpha subunit of the Gq protein
  • By GMP binding to the alpha subunit of the Gq protein

Pregunta 3

Pregunta
What is broken down by phospholipase CBeta?
Respuesta
  • Phosphatidynositol 4,5 bisphophate
  • Phosphatidynositol 3,5 bisphophate
  • Phosphatidynositol 2,4 bisphophate

Pregunta 4

Pregunta
Which product of the PCbeta pathway causes the release of calcium from the ER?
Respuesta
  • IP3
  • Diacylglycerol

Pregunta 5

Pregunta
What role(s) does the released Ca perform?
Respuesta
  • Activates protein kinase C
  • Activates protein kinase B
  • Activates various Ca dependent protein kinases

Pregunta 6

Pregunta
What residues are phosphorylated by the protein kinases activated by this pathway?
Respuesta
  • Serine
  • Threonine
  • Tyrosine

Pregunta 7

Pregunta
Which subunit of Protein Kinase C contains the pseudosubstrate domain?
Respuesta
  • PS
  • C1A
  • C4

Pregunta 8

Pregunta
What is the function of subunut C1A
Respuesta
  • DAG binding site
  • Calcium binding site
  • Phosphatidyl serine binding site

Pregunta 9

Pregunta
Do Ca 2+ and phosphatidyl serine bind to subunit C2?
Respuesta
  • Yes
  • No

Pregunta 10

Pregunta
Which subunits are part of the catalytic domain?
Respuesta
  • C1A
  • C3
  • C4
  • PS
  • C5

Pregunta 11

Pregunta
ATP binds to C2, True or False?
Respuesta
  • True
  • False

Pregunta 12

Pregunta
When IP3 causes the increase in cytosolic calcium, what happens to protein kinase C?
Respuesta
  • It moves to the membrane and binds with DAG
  • It remains in the cytoplasm and binds with DAG

Pregunta 13

Pregunta
Once protein kinase C has bound to DAG in the membrane, what does it then bind to to release the pseudosubstrate from its active site?
Respuesta
  • Phosphatidylserine
  • Phosphatidylglycine
  • Phosphatidylglutamate

Pregunta 14

Pregunta
Which of the following is a tumor promoting agent?
Respuesta
  • Phorbol ester
  • Orphol ester
  • Phenyl ester

Pregunta 15

Pregunta
How do tumor promoting agents effect Phospholipase CBeta?
Respuesta
  • They bind without being degraded, so it becomes hyperactive
  • They stop the alpha subunit binding, so it becomes unreactive
  • They cause the multiplication of the number of PCbeta enzymes in the cell, causing hyperactivity
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