39211836
Descripción
Test por Leon Schwarze, actualizado hace 5 meses
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Creado por Leon Schwarze
hace 5 meses
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Pregunta 1
Pregunta
Definition KPC
Klebsiella Pneumoniae carbapenemase
Respuesta
- True
- False
Pregunta 2
Pregunta
Beta-lactams don’t work on atypical bacteria, because:
Atypical bacteria lack cell walls and thus are naturally resistant against all beta-lactams
&
because beta-lactams act by preventing the synthesis of the bacterial cell wall.
Respuesta
- True
- False
Pregunta 3
Pregunta
Which bacteriaare intrinsically resistant to vancomycin (glycopeptide)
Respuesta
-
a) Lactobacillus
-
b) Erysipelothrix
-
c) a+b
Pregunta 4
Pregunta
Resistance to [blank_start]Quinolones[blank_end]. is caused by chromosomal mutation in structural genes of DNA gyrase and topoisomerase IV
Respuesta
-
Quinolones
Pregunta 5
Pregunta
Which Bacteria can become resistant to Macrolides
Respuesta
-
Staphylococcus
-
Streptococcus
Pregunta 6
Pregunta
In gentamicin active efflux of drug in bactericides
Respuesta
- True
- False
Pregunta 7
Pregunta
Chloramphenicol is the enzymatic modifcation of acetyltransferase-
Respuesta
- True
- False
Pregunta 8
Pregunta
Which resistant bacterias are enzymatic
Respuesta
-
PRSA
-
HLAR
-
MRSA
-
ESBL
-
KPC
Pregunta 9
Pregunta
Resistant bacterias witch are NOT enzymatic but have an altered target site
Respuesta
-
MLSb
-
PRSP
-
MBL
-
MRSA
-
VRE
Pregunta 10
Pregunta
MRSA ?
[blank_start]methicillin[blank_end] [blank_start]resistant[blank_end] [blank_start]staphylococcus[blank_end] [blank_start]aureus[blank_end]
resistant against all beta-lactams and inhibitors, excluding 5th generation of cephalosporins
Respuesta
-
methicillin
-
resistant
-
staphylococcus
-
aureus
Pregunta 11
Pregunta
Which Bacteria are resistant against Beta Lactams
Respuesta
-
MBL - Metallobetalactamases
-
KPC - Klebisella pneumonia carbapanemase / CPE - Carbapanemase producing Enterobacteriaceae
-
MRSA (with exception to 5th gen cephalosporin)
-
Mycoplasma and Chlamydia
-
Chlamydia + VRE - Vancomyocinr resistant enterococcus
Pregunta 12
Pregunta
Which of the following phenotypes relate to the enzyme production
Respuesta
-
VRE
-
ESBL - positive
-
HLAR
-
PRSP
-
MBL - positive
-
NDM - positive
Pregunta 13
Pregunta
Which of the following phenotypes relate to the enzyme production
Respuesta
-
VRE
-
ESBL
-
HLAR
-
PRSP
-
MBL
-
Ch-
Pregunta 14
Pregunta
[blank_start]PRSP[blank_end]: Resistant to narrow penicillin & possibly 3rd gen cephalosporin
Respuesta
-
PRSP
-
MRSA
-
HLAR
Pregunta 15
Pregunta
Which Bacteria are resistant to narrow penicillin
Respuesta
-
a) E.coli
-
b) PRSP
-
c) MRSA
-
d) b+c
-
e) All of the mentionend
Pregunta 16
Pregunta
Which of the following may become resistent (aquired) to tigecycline
1) E.coli
2) P.aeruginosa
3) Acinetobacter baumannii
4) proteus mirabilis
5) K. pneumoniae
Respuesta
-
a) 1,2,3,5
-
b) 1,3,5
-
c) 2,3
-
d) 3,4
-
e) 4,5
Pregunta 17
Pregunta
Modification of an existing PBP´s through recombination indicates
Respuesta
-
a) MRSA
-
b) VRE
-
c) NDM+
-
d) PRSP
-
e) PRSA
Pregunta 18
Pregunta
Which phenotype refers to MSSA
Respuesta
-
a) resistant to all beta-lactams excluding Vth generation of cephalosporin
-
b) resistant to all beta lactams including Vth generation of cephalosporin
-
c) resistant to methicillin, susceptible to oxacillin and carbapenems
-
d) susceptible to all beta lactams, excluding narrow spectrum penicillins
-
e) susceptible to all beta lactams including narrow spectrum penicillins
Pregunta 19
Pregunta
Which of the drugs are pumped out by efflux
Respuesta
-
a) Tetrayclines
-
b) Vancomycin
-
c) Tigecycline
-
d) a+c
-
e) all of the mentionend
Pregunta 20
Pregunta
Choose correct Statement
Respuesta
-
The class C beta-lactamases are primarily cephalosporinases and are encoded on bacterial chromosomes
-
Class B carbapenemases are i.A. New Delhi metallo-beta-lactamases
-
Colistin binds to the membrane instead of penetrating it
-
Tigecycline may be affected by efflux or enzymatic modification
-
Active efflux of gentamycin is commonly observed in Bacteroides fragilis
Pregunta 21
Pregunta
Which of the following phenotypes relate to the enzyme production:
1. VRE
2. ESBL-positive
3. HLAR
4. PRSP
5. MBL-positive
6. NDM-positive
Respuesta
-
a) 1,2,3,5
-
b) 2,4
-
c) 2,5
-
d) Only 4
-
e) 2,3,5,6
Pregunta 22
Pregunta
What is an “intrinsic resistance”
[blank_start]Natural resistance[blank_end]
definition they want us to write:
Bacteria is born with such a resistance, “comes into the world”
Respuesta
-
Natural resistance
Pregunta 23
Pregunta
Explain the abbreviation “NDM”: [blank_start]New Delhi[blank_end] [blank_start]Metallo-beta lactamase[blank_end]
Respuesta
-
New Delhi
-
Metallo-beta lactamase
Pregunta 24
Pregunta
Resistance to this drug results from [blank_start]acetyltransferase[blank_end] which catalyzes its acetylation. This characteristic indicates:
Chloramphenicol
Respuesta
-
acetyltransferase
Pregunta 25
Pregunta
Class B ß-Lactamases:
Respuesta
-
a.) Are Zinc dependent Metalloenzymes
-
b.) Have Broad spectrum of action
-
c.) SHV-1 and TEM-1 are Major examples
-
d.) a+b
-
e.) None of the above
Pregunta 26
Pregunta
Tetracycline resistance develops with which of the following mechanisms?
Respuesta
-
a) Decreased penetration into the bacterial cell
-
b) Active efflux of the drug
-
c) Alteration of the ribosomal target site
-
d) a+c
-
e) all of the above
Pregunta 27
Pregunta
Natural resistance is observed in:
Respuesta
-
a) Pediococcus, Leuconostonc, Erysipelothrix, Lactobacillus
-
b) E.Coli, Klebsilla
-
c) Staphylococci
-
d) a+b
-
e) none of the above
Pregunta 28
Pregunta
Pseudomonoas aeruginosa is intrinsically resistant to:
Respuesta
-
a) Tigecycline
-
b) Tobramycin
-
c) Meropenem
-
d) Ceftazidime
-
e) Sulphonamides
-
f) d+e
Pregunta 29
Pregunta
Resistance through enzymatic modification of the drug is observed in:
Respuesta
-
a. Clindamycin – Str. Pyogenes
-
b. ß-Lactams – chlamydia
-
c. E. coli – glycopeptides
-
d. Isoniazid – mycobacteria
-
e. None of the above
Pregunta 30
Pregunta
Strict anaerobic bacteria have an intrinsic resistance to:
Respuesta
-
d. Clindamycin
-
e. None of the above
-
c. Metronidazole
-
b. Ampicillin
-
a. Gentamicin
Pregunta 31
Pregunta
Which of the following phenotypes (resistance) matches the description for MRSA
Respuesta
-
a. Penicillin G, ureidopenicillin, imipenem, vancomycin – susceptible
-
b. Vancomycin, imipenem – susceptible; penicillin, 1st and 2nd Generation cephalosporins – resistant
-
c. Vancomycin – susceptible; penicillin, Cephalosporin, carbapenem – resistant d. Penicillin – susceptible; vancomycin, carbapenem, cephalosporin – resistant
-
d) a+b
-
e) none
Pregunta 32
Pregunta
Partial modification of a PBP through recombination in:
Respuesta
-
e. All of the above
-
d. Klebsiella pneumoniae
-
c. MRSA-acquisition of new pbp
-
b. Streptococcus pneumoniae
-
a. Escherichia Coli
Pregunta 33
Pregunta
Which of the following haven an aquired resistance to ß-Lactams
Respuesta
-
a) MRSA
-
b) PRSP
-
c) ESBL
-
d) a+b
-
e) All of the above
Pregunta 34
Pregunta
Strict anaerobic bacteria are resistant to:
Respuesta
-
a) Gentamicin
-
b) Penicillin
-
c) Metronidazole
Pregunta 35
Pregunta
Which of the following resistance phenotypes are associated with PBP modification
Respuesta
-
a) NDM
-
b) ESBL
-
c) PRSP
-
d) KPC
-
e) MRSA
-
f) c+e
Pregunta 36
Pregunta
Choose true Statement
Respuesta
-
a) Efflux of aminoglycosides occurs rarely in gram negative bacteria
-
b) Penicillin G is inactivated with gastric acid
-
c) Gram negative bacteria rapidly develop resistance against beta lactams by production
-
d) all of the above
Pregunta 37
Pregunta
Intrinsic Resistance to sulphonamides
Respuesta
-
a) Pseudomonas aeruginosa
-
b) Nocardia
-
c) Chlamydia
-
d) B+c
Pregunta 38
Pregunta
HLAR - [blank_start]high level[blank_end] [blank_start]aminoglycoside[blank_end] [blank_start]resistance[blank_end]
Respuesta
-
high level
-
aminoglycoside
-
resistance
Pregunta 39
Pregunta
MRSA - [blank_start]methicillin[blank_end] [blank_start]resistant[blank_end] [blank_start]staphylococcus[blank_end] [blank_start]aureus[blank_end]
Respuesta
-
methicillin
-
resistant
-
staphylococcus
-
aureus
Pregunta 40
Pregunta
Choose true combination of drugs resistance against
Respuesta
-
a) Rifampin – rna polymerase
-
b) Levofloxacin – mosaic PBP
-
c) Erythromycin – enzyme modification
-
d) Penicillin G- enzyme modification
-
e) a+c+d
Pregunta 41
Pregunta
Resistance to this drug with protein production similar to elongation factor that protects 30S ribosomal subunit indicates the resistance to?
Respuesta
-
a) Penicillin
-
b) Azithromycin
-
c) Tetracyclines
-
d) Rifampin
Pregunta 42
Pregunta
Acquired resistance to penicillin G is observed in
Respuesta
-
a) Streptococcus pyogenes
-
b) E.coli
-
c) Streptococcus pneumonia
-
d) a+c
Pregunta 43
Pregunta
Give two examples of mechanisms of resistance with change of target site?
Respuesta
-
PRSP
-
MRSA
Pregunta 44
Pregunta
Give 2 groups of drugs that are elimanted by efflux group
Respuesta
-
Quinolones
-
Tetracycline
Pregunta 45
Pregunta
Resistance to aminoglycosides
Respuesta
-
Decreased permeability
-
Enzymatic modification
Pregunta 46
Pregunta
Erythomyocin is not active against K.Pneumoniae
Respuesta
- True
- False
Pregunta 47
Pregunta
Which of the following resistant phenotypes are associated with aminoglycosides modyfying enzyme production
HLAR
Respuesta
- True
- False
Pregunta 48
Pregunta
Choose True sentence
Respuesta
-
a) Bacteria can become resistant to β-lactam antibiotics hydrolysis of the antibiotic by bacterial enzymes
-
b) Exclusion of B-lactamases in treatment of infection caused by non fermented process also due to decreased permeability of membrane
-
c) Enterobacteriaceae develop resistance to cephalosporins also due to the enzymes production
-
d) a+c
Pregunta 49
Pregunta
Intrinsic resistance to Linezolid - Escheria
Respuesta
- True
- False
Pregunta 50
Pregunta
Resistance to Metronidauole due to
Respuesta
-
Rescreased uptake of antibiotic
-
Elimination of cytotoxic compound before they reach DNA
Pregunta 51
Pregunta
Intrinsic resistance to Penicillin G - S pyogenes
- Chlamydia
Respuesta
- True
- False
Pregunta 52
Pregunta
Pumped out by efflux pump
Respuesta
-
Tetracyclines
-
Aminoglycosides
Pregunta 53
Pregunta
Which phenotype refers to MRSA?
Respuesta
-
a.) resistant to all beta lactams including vth generations of cephalosporins
-
b.) resistant to all beta lactams excluding vth generations of cephalosporins
-
c.) resistant to methicillin,susceptible to oxacillin and carbapenem
-
d.) resistant to beta lactams,resistant to vancomycin,susceptible to monobactams
-
e.) none of the mentioned
Pregunta 54
Pregunta
Enterococcus gallinarum and casseliflavus are instrinctly resistant
Respuesta
-
e)all mentioned
-
d.) a+c
-
c.) vancomycin contain D-alanine-D-serine terminus
-
b.)Linezolid
-
a.) Tigecycline
Pregunta 55
Pregunta
Correct Examples
Respuesta
-
A class beta- lactamase = SHV-1 penicillinases found in common gram negative rods (and TEM-1)
-
B class beta - lactamase= New Delhi metallo-ß-lactamases
Pregunta 56
Pregunta
Which of the following may become resistant (acquired resistant) to macrolides
Respuesta
-
S.pyogenes
-
K.pneumoniae
-
S.aureus
-
Acinetobacter baumannii
-
P.aeruginosa
-
E.coli
Pregunta 57
Pregunta
Resistance to Aminoglycosides may result from:-
Respuesta
-
e.)all mentioned
-
d.)a+c
-
c.)increased expulsion of drug from cell
-
d.)decrease uptake of drug
-
a.)mutation of ribosomal target site
Pregunta 58
Pregunta
Resistance to this drug results from acetyltransferase which catalyse to acetylation:-this characteristics indicate
Respuesta
-
e.)chloramphenicol
-
d.)imipenem
-
c.)penicillin G
-
b.)ceftriaxone
-
a.)Sulfamethoxazol
Pregunta 59
Pregunta
Intrinsic resistance to tigecyycline is observed in
Respuesta
-
a) Morganella
-
b) Providencia Proteus and P aeruginosa
-
c) Pseudomonas
-
d) b+c
-
e) all mentioned
Pregunta 60
Pregunta
Which of the following is/are enzyme producers:
1.S.pyogenes
2.ESBL +
3.HLAR +
4.PRSP
5.MBL +
6.chlamydia trachomatis
Respuesta
-
1,2,3,5
-
2,5
-
2,3,5
-
only 4
-
2,3,5,6
Pregunta 61
Pregunta
Becomes resistant to aztreonam
Respuesta
-
e. faecalis
-
p.aeruginosa
-
acinobacter baumanii
-
s.aureus
-
s epidermidis
-
s pygones
Pregunta 62
Pregunta
1. Complete information regarding the 3 ways how bacteria can become resistant to beta-lactam antibiotics:
Respuesta
-
Decreased concentration of antibiotic at the cell wall from target site
-
Decreased binding of antibiotic to the PBP
-
Enzymatic modification
-
All
-
None
Pregunta 63
Pregunta
a. ESBL - [blank_start]Extended[blank_end] [blank_start]spectrum[blank_end] [blank_start]beta lactamase[blank_end]
b. VRE - [blank_start]Vancomycin[blank_end] [blank_start]resistant[blank_end] [blank_start]enterococci[blank_end]
c. KPC - [blank_start]Klebsiella[blank_end] [blank_start]Pneumoniae[blank_end] [blank_start]Carbapenemase[blank_end]
Respuesta
-
Extended
-
spectrum
-
beta lactamase
-
Vancomycin
-
resistant
-
enterococci
-
Klebsiella
-
Pneumoniae
-
Carbapenemase
Pregunta 64
Pregunta
5. Which of the following resistance mechanism phenotypes stem from the enzymatic modification of the drug:
Respuesta
-
a. PRSA
-
b. VRE
-
c. HLAR
-
d. MBL
-
e. a+c+d
Pregunta 65
Pregunta
7. Which of the following phenotype refers to MBL + P.aeruginosa:
Respuesta
-
a. Susceptible to carbapenems, resistant to beta lactams and its combinations with inhibitors
-
b. resistant to all beta lactams with exclusion of its combination with inhibitors
-
c. resistant to all beta lactams with possible exception of aztreonam
-
d. resistant to all beta lactams with possible exception of monobactams
-
e. c+d
Pregunta 66
Pregunta
a. A class beta lactamases: [blank_start]KPC, SHV-1, TEM-1[blank_end]
b. B class beta lactamases: [blank_start]MBL, NDM, VIM[blank_end]
Respuesta
-
KPC, SHV-1, TEM-1
-
MBL, NDM, VIM
Pregunta 67
Pregunta
Which of the following may become resistant to Rifampin?
Respuesta
-
E.Coli
-
P. Aeruginosa
-
Acinebacter Baumanii
-
S. Auereus
-
S. Pneumonia
-
M. Tuberculosis
Pregunta 68
Pregunta
10. which of the following may become resistant (acquire resistance) to rifampin:
(1) E.coli
(2) P. aeurigonase
(3) acinetobacter baumanii
(4) S .aureus
(5) K .pneumonia
(6) M. tuberculosis
Respuesta
-
1,2,3,5,6
-
4,3,5
-
4,5,6
-
2,3
-
4,6
Pregunta 69
Pregunta
Choose Correct Statement
Respuesta
-
1. Resistance to amikacin can stem from decreased uptake of drug into bacterial cell
-
2. Bacteroides fragilis is intrinsically resistant to metronidazole
-
3. Most of gram (+) bacteria is resistant to macrolides
Pregunta 70
Pregunta
Which of the follwoing resistance phenotypes refers to MBL P+Aeruginosa
Respuesta
-
1. Susceptible to carbapenems, resistant to B-lactams and its combinations
-
2. Resistant to all B-lactams, with exclusion of its combination with inhibitors
-
3. Resistant to all B-lactams, with possible exception of azteonem
-
4. Resistant to all B-lactams, with possible exception of macrolides
Pregunta 71
Pregunta
Complete information regarding the ways how bacteria can become resistant to aminoglycosides:
Respuesta
-
Target site modification
-
Decreased membrane permeability
-
Active efflux
-
: Enzymatic inactivation of antimicrobial agent
Pregunta 72
Pregunta
Choose Correct Statement
Respuesta
-
a/ Pseudomonas aeruginosa is intrinsically resistant to trimethoprim.
-
b/ Overexpression of efflux pumps determines the resistance to ciprofloxacin
-
c/ Polymyxins are not effective against Gram-positive bacteria due to the lack of outer membrane in these.
Pregunta 73
Pregunta
Explain the abbreviations:
PRSP: [blank_start]Penicillin resistant[blank_end] [blank_start]streptococcus pneumoniae[blank_end]
HLAR: [blank_start]High level[blank_end] [blank_start]aminoglycoside[blank_end] [blank_start]resistance[blank_end]
NDM: [blank_start]New delhi[blank_end] [blank_start]metallo-beta-lactamase[blank_end]
Respuesta
-
Penicillin resistant
-
streptococcus pneumoniae
-
High level
-
aminoglycoside
-
resistance
-
New delhi
-
metallo-beta-lactamase
Pregunta 74
Pregunta
Intrinsic resistance to glycopeptides is observed in:
Respuesta
-
a/ Lactobacillus
-
b/ Streptococcus pneumoniae
-
c/Enterococci
-
d/ E coli
-
e/ a+d
Pregunta 75
Pregunta
Which of the following resistance phenotype refers to MRSA:
Respuesta
-
a/ Resistant to beta-lactams with possible exception of its combinations with inhibitors.
-
b/ Resistant to all beta-lactams, susceptible to Vth generation of cephalosporins
-
c/ Resistant to narrow spectrum penicillins, resistant to macrolides and lincosamides.
-
d/ Resistant to all beta-lactams, with possible exception of monobactams.
-
e/ c+d
Pregunta 76
Pregunta
Resistance to gentamicin in Bacteroides fragilis is due to...[blank_start].lack of aerobic metabolism[blank_end]
Respuesta
-
.lack of aerobic metabolism
Pregunta 77
Pregunta
Which of the following may become resistant (acquire resistance) to tigecycline:
Respuesta
-
1. Proteus mirabilis
-
2. P. aeruginosa
-
3. Morganella morganii
-
4. E. faecalis
-
5. K. pneumoniae
-
6. Providencia retgerii
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