412799
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace más de 10 años
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Pregunta 1
Pregunta
What is the main difference between apoptosis and necrosis?
Respuesta
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In necrosis release of cell contents is controlled In apoptosis it's not
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In apoptosis release of cell contents is controlled In necrosis it's not
Pregunta 2
Pregunta
What protein condenses during apoptosis
Respuesta
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Chromatin
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Actin
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Myosin
Pregunta 3
Pregunta
What form are caspases usually found in?
Respuesta
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Inactive, with their DED domain tails intact
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Active, with their DED domain tails intact
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Inactive, with their DED domain tails removed
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Active, with their DED domain tails removed
Pregunta 4
Pregunta
What is required for caspase activation?
Respuesta
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Addition of a DED domain tail
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Removal of the DED domain tail
Pregunta 5
Pregunta
What are the roles of the 2 main caspases?
Respuesta
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3 is the initation 8 does most damage
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8 is the initiator 3 does most damage
Pregunta 6
Pregunta
Which of the following are survival/protector proteins that inhibit caspase activation?
Respuesta
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BAX, BAD, PUMA
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Bci-2, Mcl1, A1
Pregunta 7
Pregunta
What is required for ligand acitvated apoptosis?
Respuesta
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For the receptors to contain DED domains
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For the receptors to be bound to caspases
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For the receptors to be expressed only in certain areas of the cell membrane
Pregunta 8
Pregunta
What protein inhibits the activation of apoptic receptors?
Respuesta
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Flp
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Flr
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Fld
Pregunta 9
Pregunta
Name an apoptic receptor
Respuesta
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Fas
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Far
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Fam
Pregunta 10
Pregunta
How does the receptor activate caspase 8?
Respuesta
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By recruiting it and cleaving off the DED domain
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By recruiting it and adding a DED domain
Pregunta 11
Pregunta
Name the two methods caspase 8 uses to destroy the cell
Respuesta
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Activation of Caspase 3
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Deactivation of Caspase 3
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Damage to mitochondria, which releases Cyt. C
Pregunta 12
Pregunta
What does mitochondrial damage do to Casp 9?
Respuesta
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Activates it
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Deactivates it
Pregunta 13
Pregunta
What happens when essential growth factors are withdrawn from the cell?
Respuesta
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PI3K cannot activate
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PKB cannot activate
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Casp 8 cannot activate
Pregunta 14
Pregunta
How does PKB inhibit apoptosis?
Respuesta
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Releases Bad from Blc-2
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Releases Blc2 from Bad
Pregunta 15
Pregunta
Identify methods which cells can use to evade apoptosis
Respuesta
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Decreased Fas receptor expression
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Inc Blc2 & decrease bax/bad expression
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Loss of Casp 8
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Increased Flp expression
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Soluble fas to causes apoptosis in t-cells
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Large amounts of Fas ligand produced to kill t-cells
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