Nuclear Signalling by Ras

Description

Year 2 Flashcards on Nuclear Signalling by Ras, created by gina_evans0312 on 02/12/2013.
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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 almost 11 years ago
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Resource summary

Question Answer
No of Types of Raf 3- A,B & C
Most important form of Raf B-Raf
Mutation making Raf an oncogene Val-Glutamine
14-3-3- Family Interact with phospho-serine by forming heterodimers
14-3-3 Binding on B-Raf Ser-259 & Ser 691
Dephosphorylation of Ser... once recruited to membrane Ser 259
Membrane Associated Kinases Phosphorylate Raf to activate it
Cytosolic Kinases Rephosphorylate Ser259 when Raf is removed from the membrane
Activation of Mek Phosphorylation on Serine/Threonine
CD Domain of Erk TEY sequence (T & Y phosphorylated by MEK)
Once phosphorylated, Erk... Signals the nucleus (including phosphorylation of TCF/ELK1)
Does ERK enter the nucleus? Yes
p90rsk Activated by ERK & enters nucleus
NF(Kappa)B Activation Releases transcription factor to enter nucleus
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