Complimentation Tests & Epistasis

Descripción

Year 2 Test sobre Complimentation Tests & Epistasis, creado por gina_evans0312 el 16/12/2013.
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Test por gina_evans0312, actualizado hace más de 1 año
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Resumen del Recurso

Pregunta 1

Pregunta
The complimentation test is used to find out if mutations are allelic or non allelic
Respuesta
  • True
  • False

Pregunta 2

Pregunta
In what circumstances will a Complimentation Test give a false result?
Respuesta
  • When the mutation is recessive
  • When the mutation is dominant
  • When the mutated gene is part of a complex
  • Where proteins form multimers

Pregunta 3

Pregunta
Genotypes M1 & M2 are bred together, and a Wild Type result is obtained- are the mutations allelic
Respuesta
  • No- as the presentation of a wild type phenotypes shows there is at least one dominant wild type allele for each gene
  • Yes- The two mutations on the same allele are able to compliment each other sufficiently to produce a wild type phenotype

Pregunta 4

Pregunta
If M3 and M2 are bred together and they present as M2, what does this tell us about the mutation's location?
Respuesta
  • They are on the same allele- there is no dominant wild type allele to mask their activity
  • They are on separate alleles, but M2 has a far greater effect than previously thought

Pregunta 5

Pregunta
According to the above table, which mutations are allelic
Respuesta
  • M9 & M4
  • M8 & M6
  • M2
  • All of the above

Pregunta 6

Pregunta
A Complimentation Test can be fooled if the mutant protein can form a functioning heterodimer with the wild type protein
Respuesta
  • True
  • False

Pregunta 7

Pregunta
One gene is said to be epistatic to another if...
Respuesta
  • The presence of a double mutant exhibits the phenotype of the mutant gene
  • The presence of the wild type masks the phenotype of the mutant gene
  • A genes expression causes a change in the expression of another gene further down the pathway

Pregunta 8

Pregunta
Where are epistatic genes usually found in substrate dependent pathways?
Respuesta
  • Upstream
  • Downstream

Pregunta 9

Pregunta
A substrate dependent pathway is a series of positive and negative regulators that act on one another of the final product
Respuesta
  • True
  • False

Pregunta 10

Pregunta
This image is of a Switch Regulatory Pathway
Respuesta
  • True
  • False

Pregunta 11

Pregunta
Why should null alleles be used for epistatic analysis (i.e how to find out the order of gene function in a pathway)
Respuesta
  • The masking of alleles downstream becomes obvious
  • They are easier to make than hypomorphic alleles
  • They can be used for both Substrate Dependent and Switch pathways

Pregunta 12

Pregunta
How do we identify that the pathway effected by the (epistatic) mutation is a Switch Regulatory pathway?
Respuesta
  • If the mutation prevents the production of the final product
  • If the phenotype of a double mutant is different to the phenotype of either single mutant

Pregunta 13

Pregunta
The Rif1 & Rif2 strains are both causes lengthened telomeres, as shown in the diagram. Based on the Rif1/Rif2 double mutation, which of the two availible pathways (shown) is likely to be the one used?
Respuesta
  • Pathway A
  • Pathway B
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