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Creado por Isobel Setford
hace más de 8 años
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Pregunta | Respuesta |
What are ALTs and ASTs markers of | Hepatocellular injury |
What do ALTs and ASTs do? | They participate in gluconeogensis by catalysing the transfer of aspratic acid or alanine to ketoglutaric acid to produce oxaloacetic acid and pyruvic acid |
In what isoenzymes is AST present? | Cytosolic and mitochondrial |
In what tissues can ASTs be found? | Liver, striated muscle, brain, pancrease, leukocytes, RBCs, kidneys and lungs |
Which out of ASTs or ALTs are more specific to liver function | ALTs (L for liver!!) |
What is the difference in tissue activity and distribution between ASTs and ALTs? | They both have similar tissue distribution, but ALTs are less active in extra-hepatic tissues. |
What is Alkaline Phosphate derived from? | The liver - on the surface of the bile canalicular membrane |
How does Alkaline Phosphate in the liver enter the bloodstream? | Via the paracellular pathway |
What does a rise in serum ALP mean? | Bile duct obstruction, bone disease or during bone growth |
Is gamma glutamyl transferase a mitochondrial isoenzyme? | Yes |
What is an inidcator of chonic alcohol consumption? | High plasma GGT levels |
What does a rasied GGT and ALP mean? | Cholstasis (gallstones or head of pancreas cancer) and some liver diseases. |
Does the liver produce immunoglobins? | False - but it produces all other plasma proteins |
What is the most important plasma protein produced by the liver | Albumin |
What is prothrombin time a measure of? | The rate of conversion of pro-thrombin to thrombin - reflects a vital synthetic function of the liver |
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