muhammed's spleen is palpable

spleen
1. cuases of splenomegaly
  1. primary or metastatic neoplasm
    1. leukemia
    2. lymphoma
    3. carcinoma
    4. sarcoma
  2. hemolytic anemias
  3. immunologicinflammatory disorders
    1. lupus
    2. sarcoidosis
    3. amyloidosis
  4. storage diseases
    1. gaucher
    2. neimann pick
  5. splenic vein hypertension
    1. cirrhosis
  6. complications
    1. spleen infarction
    2. frequent infections &easy bleeding
    3. anemia
    4. fulleness
  7. grades
2. upper left quadrant of the abdomen
3. histology
  1. stroma
    1. capsule
    2. trabeculae
    3. reticular network
  2. parenchyma
    1. white pulp
    2. red pulp
4. physical examination
  1. supine position
who can donate blood
1. aged between 17 and 66
2. weight over 50kg
3. doesn't have diseases like
  1. high blood pressure
  2. diabetes
  3. anemia
WBC's
1. disorders
  1. neoplastic
    1. myeloid
      1. Acute myeloid leukemia
        Age 15-60
        >20% blast cells in BM and blood
        Auer bodies
      2. chronic myeloproliferative disorder
        JAK2 mutations
        essential thrombocythemia
        myelofibrosis
        Polycythemia vera
        BCR-ABL t(9:22)
        chronic myeloid leukemia
        Age 40-60+
        decreased LAP
        stages
        chronic phase
        Accelerated phase
        Blast phase
        treatment
        stem cell transplants
        imatinib
        tyrosin kinase inhibitor
        risk factors
        ionizing radiation in high doses
        epidemiology
        slow progression
        pathophysiology
    2. lymphoid
      1. non hodgkin's lymphoma
      2. multiple myeloma
      3. Hodgkin's lymphoma
      4. chronic lymphocytic leukemia
        Age 60+
        proliferation of neoplastic lymphoid cells (B cells)
        sumdge cells
      5. Acute lymphoblastic leukemia
        Age <15
        composed of pre B or pre T lymphocytes
        +TDT test
    3. histiocytic
  2. non neoplastic
    1. reactive leukomoid reaction
      1. excessive leucocytosis that may mimic leukemia
      2. 15000-100,000 cells/µL
      3. elevated NAP
      4. presence of cytoplasmic toxic granulation
    2. related diseases
investigations
1. CBC
2. blood smear
  1. normal
3. genetic test
  1. conventional cytogenetics
  2. PCR
  3. FISH
4. BM biopsy or aspiration

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muhammed's spleen is palpable

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	Creado por yasmin alkhatib hace más de 7 años