Metabolism of Early Fasting

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Year 2 (Metabolic States) Flashcards on Metabolism of Early Fasting, created by gina_evans0312 on 28/02/2014.
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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Question Answer
Inslun:Glucaon Ratio 0:0.15
Blood Glucose Levels Will vary in this state, and change the metabolic processes with them
Liver- Glucose Uptake Since plasma glucose as fallen, the GLUT2 receptors can no longer take up glucose
Liver- Glycogen Broken down by glycogen phosphatase to glucuse
Liver- Glucose Either uses GLUT2 to exit the liver or is made into Phospoenoylpyruvate (PEP)
Liver- Alanine/Lactate Enters liver to make Phosphoenoylpyruvate (PEP)
Liver- Phosphoenoylpyruvate (PEP) Blood Glucose Low- Made into glucose Blood Glucose High- Made into pyruvate
Liver- Amino Acids Made from pyruvate in other cells, then used to make pyruvate in the liver
Liver- Pyruvate Blood Glucose High- Makes acetyl CoA Blood Glucose low- made back into PEP
Liver- Acetyl CoA Depending on blood glucose levels, either TCA or TAG generation
Adipose Tissue- Glucose Transporters Still GLUT4, but fall in numbers due to decrease in insulin
Adipose Tissue- Glycolysis/TAG Synthesis Switched off entirely (not enough glucose entering for enzymes to be in active states)
Adipose Tissue- TAGs Broken down in to glycerol (for transport to liver) or to be used as fuel by muscle
Muscle- Glucose Transporters Reduced Nos of GLUT4
Muscle- Glucose Little is converted into glycogen, most is used
Muscle- Glucagon Receptors None- so glycogen only breaks down according to the muscles needs
Muscle- F.A's Enter from blood and used to generate pyruvate for fuel
Muscle- Protein Broken down to Alanine and transported to the liver to make glucose
Muscle- Pyruvate Made into glutamine (and transported to liver) or generates lactose during exercise
Brain Tissue Stays the same (brain can't use F.As)
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