Glycolysis & PFK1/F1,6BPase

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Year 2 (Glycolysis) Flashcards on Glycolysis & PFK1/F1,6BPase, created by gina_evans0312 on 30/03/2014.
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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Question Answer
Function of Glycolysis Provides ATP from glucose, Acetyl CoA for FA synthesis, and carbon skeletons for aa sythesis
In Muscle, glycolysis and gluconeogenesis are Simultaneous, as one feeds the other
In liver, glycolysis and gluconeogenesis are... Incompatable- glucose produced must exit the liver to be used elsewhere
Glycolysis Regulation Control glucose entry (GLUT2) or at committed steps
PFK1 6- Phosphofructokinase 1 (the first committed enzyme) converts Fru-6-P to Fur-1,6-BP
PFK1 Structure Tetramer, with tense (active) and relaxed (inactive) form
PFK1- ATP Binding 2 sites- one allosteric, one catabolic (binds regardless of tense/relaxed state)
PFK1- Allosteric ATP Excess ATP binds and encourages tense state (indicated energy dense cell)
PFK1- F-6-P binding Only occurs in relaxed state
PFK1- Allosteric AMP Competes with ATP in low ATP concs, encouraging relaxed state
PFK1- H+ ions Indicate high levels of anaerobic respiration and so PFK1 is shut down for cellular protection
Heart PFK1- H+ ions Even in high H+ concs, heart PFK1 remains active as shutting it down is potentially fatal
PFK1- Citrate Inhibits PFK1 (Signals TCA cycle overload)
PFK1- F-6-P Signals Glucose entry/breakdown, acts as feedforward mechanism
PFK1- F-2,6-BP Potent allosteric activator
F-1,6-BPase Reverses action of PFK1 (though PFK1 works 10x faster)
Active F-1,6-P Location Muscles undergoing gluconeogenesis
F-1,6-P - AMP At low AMP, F-1,6-P activity exceeds that of PFK1 (this reverses as AMP levels rise)
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