694047
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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| Question | Answer |
| PFK2 | Performs same role as PFK1, but generates Fru-2,6-BP instead |
| Role of Fru-2,6-BP | Most potent known activator of PFK1 (sole purpose is to act as a signalling molecule) |
| PFK2- F-6-P & AMP | Signal activation (High levels of each indicate low energy status and excess F-6-P |
| PFK2- Citrate | Inhibited- TCA Cycle overload |
| Role F-2,6-BPase | Reverses PFK2 to keep PFK1 inhibited |
| F-2,6-BPase in the liver | Keeps glycolysis inhibited except in fed states |
| Liver PFK2/F-2,6-BPase | Same enzyme with 2 active sites (1 PFK2, other is F-2,6BPase) |
| Liver-PFK2- Allostery | Same as normal PFK2 |
| PFK2- Phosphorylation | Done by cAMPPK, causes inactivation |
| F-2,6-BPase- Phosphorylation | Activated by it |
| Dephosphorylatiors of PFK2 & F-2,6BPases | Though insulin stimulated Protein Kinases or Xylose-5-phosphate (Pentose pathway) |
| Pentose Pathway | Generates NADPH for fat synthesis |
| Protein Phosphatase 2 | Activated by Xylose-5-phoshphatase, removes P from PFK2/F-2,6-BP |
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