PFK2/F-2,6-BPase

Question	Answer
PFK2	Performs same role as PFK1, but generates Fru-2,6-BP instead
Role of Fru-2,6-BP	Most potent known activator of PFK1 (sole purpose is to act as a signalling molecule)
PFK2- F-6-P & AMP	Signal activation (High levels of each indicate low energy status and excess F-6-P
PFK2- Citrate	Inhibited- TCA Cycle overload
Role F-2,6-BPase	Reverses PFK2 to keep PFK1 inhibited
F-2,6-BPase in the liver	Keeps glycolysis inhibited except in fed states
Liver PFK2/F-2,6-BPase	Same enzyme with 2 active sites (1 PFK2, other is F-2,6BPase)
Liver-PFK2- Allostery	Same as normal PFK2
PFK2- Phosphorylation	Done by cAMPPK, causes inactivation
F-2,6-BPase- Phosphorylation	Activated by it
Dephosphorylatiors of PFK2 & F-2,6BPases	Though insulin stimulated Protein Kinases or Xylose-5-phosphate (Pentose pathway)
Pentose Pathway	Generates NADPH for fat synthesis
Protein Phosphatase 2	Activated by Xylose-5-phoshphatase, removes P from PFK2/F-2,6-BP

Resource summary

	Created by gina_evans0312 over 10 years ago