null
US
Sign In
Sign Up for Free
Sign Up
We have detected that Javascript is not enabled in your browser. The dynamic nature of our site means that Javascript must be enabled to function properly. Please read our
terms and conditions
for more information.
Next up
Copy and Edit
You need to log in to complete this action!
Register for Free
12040822
Role of Y chromosome in cancer
Description
Mind Map on Role of Y chromosome in cancer, created by Lectura y redacción Científica on 30/01/2018.
Mind Map by
Lectura y redacción Científica
, updated more than 1 year ago
More
Less
Created by
Lectura y redacción Científica
over 6 years ago
23
1
0
Resource summary
Role of Y chromosome in cancer
Sex differences in risk and incedence of diseases
32 of 36 cancers types male preference of mortality
Major genetic differences: Y chromosome
Prone to X-linked mutations
Y Chromosome
Three regions
MSY
23 genes and multiple pseudogenes
No meiotic recombination
Two groups
Group 1
ubiquitously
Balanced expresion crucial for maintain healthy conditions in men
Group 2
Specifically testis
Diverse functions than X homologs
Major Locci
TDF
GBY
short arm proximal to centromere
AZF
long arm
PAR1 and PAR2
20 protein coding-genes
Are present in X and Y chromosome
Meiotic recombination
Heterochromatin region Yq
Y linked genes and cancer
TSPY and RMY ectopically expressed in disease
Normally expressed in testicular germ cells
Y chromosome genes influence liver cancer
Testis Specific Protein(TSPY)
Expressed in: gonocytes, spermatogonia and prophase
Could promote gonadoblastoma and GCTs
Express in some somatic cancer including liver cancer, melanoma and prostate cancer
Member of SE translocation assembly protein1 (SET/NAP1)
Histone chaperone (Shuttin and assembling)
Inhibitor of INHAT
INHAT inhibits histone acetylation
Suppress expresion genes
Overexpression: reduces G2/M phase
Accelerate cell proliferation
TSPY and TSPX same ancestor
Contrasting roles
5 type of GCTs
Type-I
Teratoma sac tumor
Type-II
Seminomatous GCTs
Type-III
permatocytic seminoma
Type-IV
Dermoid Cyst
Type-V
hydatidiform mole
Overexpression of TSPX retards cell proliferation
Show full summary
Hide full summary
Want to create your own
Mind Maps
for
free
with GoConqr?
Learn more
.
Similar
SAT Vocabulary
Muffins31
Question Words - GCSE German
lucykatewarman1227
Physics equations
helensellers75
Forces and Acceleration
Adam Collinge
A level Henry VIII: Foreign policy
avocadolover
English Grammatical Terminology
Fionnghuala Malone
GCSE Biology Unit 1 AQA
Archie Clay
The Periodic Table
Catherine Kidd
CONCEPTUAL MAP
Andres Sanchez
Tips for Succeeding on the Day of the Exam
Jonathan Moore
AAHI_Card set 1 (Anatomical, Medical Terminology)
Tafe Teachers SB
Browse Library