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21893064
UGT1A1
Description
Uridín 5-difosfoglucuronosil trasferasa 1
Mind Map by
yajaira sangucho
, updated more than 1 year ago
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Created by
yajaira sangucho
over 4 years ago
2
0
0
Resource summary
UGT1A1
Enzima FASE II
Función
conjuga C6H10O7 con moléculas lipofílicas
ejm:bilirrubina
eliminación
por bilis
codificado
gen UGT1A1
polimorfismo
alelo*28
característica
1 repetición adicional de AT en región promotora
> 30% expresión de enzima
< concentración de bilirrubina en sangre
60-70%
efecto tóxico
gastrointestinal
médula osea
IRINOTECAN
SN-38
>riesgo tóxico
neuropenia
diarrea
metabolito citotóxico
inhibidor de topoisomerasa 1
afecta
Media attachments
Pastilla (binary/octet-stream)
Menos (binary/octet-stream)
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