1187995
Description
Mind Map by wilmaluvsya, updated more than 1 year ago
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Created by wilmaluvsya
over 10 years ago
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Microcytic, Hypochromic Anemia
- Thalassemia
- Is characterised by decreased synthesis of the globin chains leading to
microcytosis and then microcytic hypochromic anemia
- Is characterised by decreased synthesis of the globin chains leading to
microcytosis and then microcytic hypochromic anemia
- Iron Deficiency
- With Iron deficiency,
the iron stores ie
ferattin have been
systematically
becoming depleted.
As a result serum iron
levels become low
when the iron stores
have been depleted.
The amount of
transferrin is elevated
so that any iron can
be bound to the
molecule and aid in
erythropoiesis.
- With Iron deficiency,
the iron stores ie
ferattin have been
systematically
becoming depleted.
As a result serum iron
levels become low
when the iron stores
have been depleted.
The amount of
transferrin is elevated
so that any iron can
be bound to the
molecule and aid in
erythropoiesis.
- Sideroblastic Anemia
- Some drugs and toxins
have the ability to interfere
with heme synthesis; an
example of such a toxin is
lead. Lead inhibits an
important enzyme that
allows for the incorparation
of iron into the heme. As a
result, iron is not
incorparated and
erythropoiesis is altered. Via
the RBC becoming
hypochromic and microcytic.
The RBC themselves show
the characteristic of ringed
sideroblasts as iron forms
granules around the cell due
to it not being incorparated.
- Some drugs and toxins
have the ability to interfere
with heme synthesis; an
example of such a toxin is
lead. Lead inhibits an
important enzyme that
allows for the incorparation
of iron into the heme. As a
result, iron is not
incorparated and
erythropoiesis is altered. Via
the RBC becoming
hypochromic and microcytic.
The RBC themselves show
the characteristic of ringed
sideroblasts as iron forms
granules around the cell due
to it not being incorparated.
- Anemia of Chronic Disease
- When someone has an infection
the physiological responses are
that iron stops being absorped as
well as being transported in the
body via the protein transferrin.
This is to make sure that
pathogens in the body do not utlise
iron. Hepcidin is the hormone
which is used to inhibit
reabsorption of iron as well as
transport of it during inflammation
Chronic Disease/ infection leads to
increased levels of hepcidin
meaning decreased levels of
serum iron even though the
storage facilities (ferratin) are still
available. Because Iron is essential
for erythropoiesis the blood film
would show microcytic,
hypochromic Anemia.
- When someone has an infection
the physiological responses are
that iron stops being absorped as
well as being transported in the
body via the protein transferrin.
This is to make sure that
pathogens in the body do not utlise
iron. Hepcidin is the hormone
which is used to inhibit
reabsorption of iron as well as
transport of it during inflammation
Chronic Disease/ infection leads to
increased levels of hepcidin
meaning decreased levels of
serum iron even though the
storage facilities (ferratin) are still
available. Because Iron is essential
for erythropoiesis the blood film
would show microcytic,
hypochromic Anemia.
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