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253749
Soft tissue tumours:
Description
Pathology Mind Map on Soft tissue tumours:, created by Emma Jones on 05/10/2013.
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pathology
pathology
Mind Map by
Emma Jones
, updated more than 1 year ago
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Created by
Emma Jones
almost 11 years ago
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Resource summary
Soft tissue tumours:
Muscle, fat, fibrous tissue, blood vessels, peripheral nerves
Benign lesions
Lipoma
Benign adipose tissue tumour, usually subcutaneous, sites where adipose tissue is normally present
Middle/late adult life
Well circumscribed, resemble mature fat
Subtypes: fibrolipoma, chondroid lipoma, spindle cell lipoma, pleomorphic lipoma, angiolipoma
Ganglia
In vicinity of joints, sometime tendon sheaths
Myxoid softening and cystic degeneration of tissues of joint capsule or tendon sheath
Dorsal hand, wrist, foot, ankle, knee, spine --> not lined by true synovium, do not communicate
Aggressive benign
Fibromatoses
Well differentiated fibroblastic proliferations, infiltrative growth pattern, aggressive, repeated local recurrence
Classification
Deep/musculo-aponeurotic/desmoid tumours
5-10cm, firm, grey, scar-like
Spindle cells, fibroblastic, collagen stroma, infiltrative growth
Superficial: Dupytron's contracture
Pseudosarcomatous
Nodular fasciitis
Young adults --> arms, trunk, neck
Rapid growth of tender mass, associated with fascia --> infiltration of subcutis, muscle, fascia
Spindle cell proliferation, stroma rich with ground substance, infiltrative, mitotically active, no malignant potential
Liposarcoma
Adult --> thigh, retroperitoneum
Large, well-circumscribed, unencapsulated
Low grade: myxoid, well-differentiated
High grade: round cell, pleomorphic
Synovial sarcoma
5-10% of soft tissue sarcomas, high grade
Young adults, M>F, 80% knee/ankle
Other sites: head, neck, retroperitoneum, mediastinum
Enlarging mass, pain, infrequent systemic symptoms
Well circumscribed, pink/grey
Monophasic or biphasic, poor differentiation
Biphasic: carcinomatous & sarcomatous
t(x;18)
Poor prognosis
Diagnosis takes into account history, location, radiological apperance --> differential diagnosis
Prebiopsy planning required --> inappropriate biopsy leads to wrong diagnosis or healing complications
Fine needle aspiration
Diagnostic closed core biopsy
Open biopsy/curettage
Formal resection
Open biopsy creates complication, but less invasive procedures might not obtain enough tissue for diagnosis
Diagnosis of chromosomal abnormality
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Enneking (image/jpg)
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