404505
Description
Mind Map by fatimaelfitouri, updated more than 1 year ago
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Created by fatimaelfitouri
about 11 years ago
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Cytokine receptors
- GHR
- Jaks-stat-socs
- inhibition
- SOCS
- PIAS
- CIS
- SOCS
- Jaks-stat-socs
- 3 groups
- type I
- also known as hematopoietin receptor
- Share 3 common components: either gp130, bc, gc
- Divided into 3 groups depending on which
component they utilise (gp130, bc or yc)
- also known as hematopoietin receptor
- Type II
- also known as interferon receptors
- also known as interferon receptors
- another group responds to proinflammatory cytokines
- both type I and II lack intrinsic protein kinase
activity, they are structurally distinct
- type I
- cytokine
- polypeptide or low molecular weight protein involved in cell-to-cell signaling
- Acts in paracrine or autocrine fashion through specific cellular receptors
- Can be produced by cells of any tissue and act on many cells involved in
immune and inflammatory response
- act like hormones
- eg interleukins, TGF-b and chemokines
- Cytokines that use the same receptor component usually have
overlapping effects in the immune system
- polypeptide or low molecular weight protein involved in cell-to-cell signaling
- signalling
- ligand binds to dimer receptor
or monomer receptors that
dimerse
- ligand binding recruits JAK
- jak2 transphosophorylate each other
- stat1 is recruited, phosphorylated and
dimerised with another stat
- stat dimer translocated to the nucleus
and regulates transcription
- stat dimer translocated to the nucleus
and regulates transcription
- stat1 is recruited, phosphorylated and
dimerised with another stat
- jak2 transphosophorylate each other
- ligand binding recruits JAK
- ligand binds to dimer receptor
or monomer receptors that
dimerse
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