Copy and Edit

Blood pressure

Description

Reference: Robbin's Basic Pathology Chapter 9
Shaima Amanda
Mind Map by Shaima Amanda, updated more than 1 year ago
Shaima Amanda
Created by Shaima Amanda almost 11 years ago
37
0
0

Resource summary

Blood pressure
  1. Major regulator: Renin
    1. Juxtaglomerular cells
      1. Cleaves Angiotensinogen to AT-1
        1. AT-1 to AT-2
          1. Stimulates adrenal gland to secrete aldosterone
            1. Increases blood volume
              1. -ve feedback by Myocardial natriuretic peptide
            2. Increases sodium resorption
              1. Vasoconstriction
          2. Benign Hypertension
            1. Malignant Hypertension
              1. Hyperplastic arteriosclerosis
                1. Decreased sodium excretion
                  1. Increased blood volume and blood pressure
                  2. Genetic factors/ Environmental factors
                    1. Atherosclerosis
                      1. Atheroma
                        1. Cholesterol, cholesterol esters, necrotic debris and fibrotic caps
                        2. Thrombosis
                          1. Risk Factors
                            1. Modifiable
                              1. Hyperlipidemia/ hypercholesterolemia
                                1. Good cholesterol
                                  1. HDL. HDL mobilzes the cholesterols from plaques to the liver
                                    1. Exercise and ethanol increases HDL
                                      1. Smoking and obesity decreases HDL
                                    2. Bad cholesterol
                                      1. LDL. LDL distributes the cholesterol in the peripheral tissues
                                        1. Statins lower the circulating cholesterol
                                          1. Statins lower CRP levels
                                            1. CRP is synthesised by liver. It is a biomarker which predicts the risk of MI.
                                    3. Hypertension
                                      1. Ischemic heart disease
                                        1. Left ventricular hypertrophy
                                        2. Smoking
                                          1. Diabetes mellitus
                                            1. Atherosclerosis related GANGRENE
                                              1. Myocardial infarction
                                            2. Constitutional/ nonmodifiable
                                              1. Genetics
                                                1. Familial hypercholesterolemia
                                                2. Age
                                                  1. 40-60 yrs
                                                  2. Gender
                                                    1. Males are more prone. Postmenopausal women are also at more risk compared to premenopausal
                                                3. Coronary Artery Disease
                                                  1. Lipoprotein-a : Apolipoprotein B100 and Apolipoprotein-a
                                                  2. Atherogenesis
                                                    1. Endothelial injury
                                                      1. Endothelial dysfunction
                                                        1. Monocyte-macrophages
                                                          1. Platelet adhesion
                                                            1. Smooth muscle recruitment
                                                              1. Lipid accumulation
                                                                1. Fatty streaks
                                                                  1. Atherosclerotic plaques
                                                                    1. Smooth muscle cells, T-cells and macrophages
                                                                      1. Intracellular and extracellular lipid accumulation
                                                                        1. ECM, collagen, elastin, proteoglycans
                                                                          1. LEADS TO THROMBOSIS
                                                                            1. EMBOLISM
                                                                              1. Plaque rupture
                                                                                1. Plaque erosion
                                                                                  1. Plaque hemorrhage
                                                                        2. Hyaline arteriosclerosis
                                                                          1. Nephrosclerosis
                                                                        Show full summary Hide full summary

                                                                        Want to create your own Mind Maps for free with GoConqr? Learn more.

                                                                        Similar

                                                                        Fluid and Electrolyte Imbalances
                                                                        D R
                                                                        Infectious diseases
                                                                        Clare Yu
                                                                        Epidemiology
                                                                        Danielle Richardson
                                                                        Respiration
                                                                        Sarita Saha
                                                                        Transport in mammals
                                                                        Aarushi Pandit
                                                                        History of Medicine: Ancient Ideas
                                                                        James McConnell
                                                                        Epithelial tissue
                                                                        Morgan Morgan
                                                                        4. The Skeletal System - bones of the skull
                                                                        t.whittingham
                                                                        Laboratory Tools
                                                                        Christopher Nikolo R. Magtoto
                                                                        Neuro anatomy
                                                                        James Murdoch
                                                                        The Endocrine System
                                                                        DrABC
                                                                        Browse Library