muhammed's spleen is palpable

Description

Medicine Mind Map on muhammed's spleen is palpable, created by yasmin alkhatib on 06/05/2017.
yasmin alkhatib
Mind Map by yasmin alkhatib, updated more than 1 year ago
yasmin alkhatib
Created by yasmin alkhatib over 7 years ago
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Resource summary

muhammed's spleen is palpable
  1. spleen
    1. cuases of splenomegaly
      1. primary or metastatic neoplasm
        1. leukemia
          1. lymphoma
            1. carcinoma
              1. sarcoma
              2. hemolytic anemias
                1. immunologicinflammatory disorders
                  1. lupus
                    1. sarcoidosis
                      1. amyloidosis
                      2. storage diseases
                        1. gaucher
                          1. neimann pick
                          2. splenic vein hypertension
                            1. cirrhosis
                            2. complications
                              1. spleen infarction
                                1. frequent infections &easy bleeding
                                  1. anemia
                                    1. fulleness
                                    2. grades
                                    3. upper left quadrant of the abdomen
                                      1. histology
                                        1. stroma
                                          1. capsule
                                            1. trabeculae
                                              1. reticular network
                                              2. parenchyma
                                                1. white pulp
                                                  1. red pulp
                                                2. physical examination
                                                  1. supine position
                                                  2. who can donate blood
                                                    1. aged between 17 and 66
                                                      1. weight over 50kg
                                                        1. doesn't have diseases like
                                                          1. high blood pressure
                                                            1. diabetes
                                                              1. anemia
                                                            2. WBC's
                                                              1. disorders
                                                                1. neoplastic
                                                                  1. myeloid
                                                                    1. Acute myeloid leukemia
                                                                      1. Age 15-60
                                                                        1. >20% blast cells in BM and blood
                                                                          1. Auer bodies
                                                                          2. chronic myeloproliferative disorder
                                                                            1. JAK2 mutations
                                                                              1. essential thrombocythemia
                                                                                1. myelofibrosis
                                                                                  1. Polycythemia vera
                                                                                  2. BCR-ABL t(9:22)
                                                                                    1. chronic myeloid leukemia
                                                                                      1. Age 40-60+
                                                                                        1. decreased LAP
                                                                                          1. stages
                                                                                            1. chronic phase
                                                                                              1. Accelerated phase
                                                                                                1. Blast phase
                                                                                                2. treatment
                                                                                                  1. stem cell transplants
                                                                                                    1. imatinib
                                                                                                      1. tyrosin kinase inhibitor
                                                                                                    2. risk factors
                                                                                                      1. ionizing radiation in high doses
                                                                                                      2. epidemiology
                                                                                                          1. slow progression
                                                                                                            1. pathophysiology
                                                                                                        1. lymphoid
                                                                                                          1. non hodgkin's lymphoma
                                                                                                            1. multiple myeloma
                                                                                                              1. Hodgkin's lymphoma
                                                                                                                1. chronic lymphocytic leukemia
                                                                                                                  1. Age 60+
                                                                                                                    1. proliferation of neoplastic lymphoid cells (B cells)
                                                                                                                      1. sumdge cells
                                                                                                                      2. Acute lymphoblastic leukemia
                                                                                                                        1. Age <15
                                                                                                                          1. composed of pre B or pre T lymphocytes
                                                                                                                            1. +TDT test
                                                                                                                          2. histiocytic
                                                                                                                          3. non neoplastic
                                                                                                                            1. reactive leukomoid reaction
                                                                                                                              1. excessive leucocytosis that may mimic leukemia
                                                                                                                                1. 15000-100,000 cells/µL
                                                                                                                                  1. elevated NAP
                                                                                                                                    1. presence of cytoplasmic toxic granulation
                                                                                                                                    2. related diseases
                                                                                                                                2. investigations
                                                                                                                                  1. CBC
                                                                                                                                    1. blood smear
                                                                                                                                      1. normal
                                                                                                                                      2. genetic test
                                                                                                                                        1. conventional cytogenetics
                                                                                                                                          1. PCR
                                                                                                                                            1. FISH
                                                                                                                                            2. BM biopsy or aspiration
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