1887655
Descrição
FlashCards por Marielle83, atualizado more than 1 year ago
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Criado por Marielle83
quase 10 anos atrás
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| Questão | Responda |
| Which drugs makes up the CHOP chemo protocol? | C - Cyclophosphamide H - Doxorubicin O - Vincristine P - Prednisolone |
| Which of the CHOP drugs are contraindicated in cardiac disease? | Doxorubicin |
| What 3 groups of drugs are used in the treatment of bradycardia? | Muscarinic antagonists Beta-agonists Methylxanthines |
| What AARD's are used in the treatment of tachycardia? | Class 1: Sodium channel blockers Class 2: Beta-blockers Class 3: Potassium channel blockers Class 4: Calcium channel blockers Digoxin (cardiac glycoside) |
| Which are the broad spectrum antifungal drug groups available in vet medicine? | Azoles Polyenes |
| MOA for Griseofulvin? | Inhibits fungal growth! Desposited in newly formed keratin, inhibits mitosis, disorganise spindle microtubules. |
| MOA for Antimetabolites? | Disrupts protein synthesis: Converted in fungal body to 5-fluorouracil which is confused by the fungus for uracil --> rubbish message created |
| The 4 groups of antiviral drugs used in vet medicine. | 1. Ion channel blockers 2. Reverse transcriptase inhibitors 3. DNA polymerase inhibitors 4. Neuraminidase inhibitors |
| Zidovudine (AZT) - a reverse transcriptase inhibitor is active against what virus? | Retrovirus |
| Amandatine - an ion channel blocker, is active against what type of virus? | Influenza A |
| Spectrum of activity of Benzimidazoles? | Broad; also larvidical and ovicidal |
| MOA of Imidazothiazoles? | Ganglion stimulant; nicotinic agonist Paralyse nematode by sustained muscular contraction |
| MOA of Macrolytic Lactones? | Stimulate glutamate gated Cl-channels in invertebrate nerve and muscle cells - Cl influx causes hyperpolarisation of post-synaptic cells - flaccid paralysis |
| MOA of the fluke drug Salicylanide? | Uncouples OxPhos |
| Ivermectin is an example of what class of drugs? | Macrolytic Lactones |
| Spectrum of action for Ivermectin? | All major GI + lung nematodes in ruminants, horses and swine GI nematodes and heart worms in dogs |
| Organophosphate side effects are DUMBELS, what does this stand for? | Diarrhoea, Urination, Mitosis, Bronchoconstriction, Emesis, Lacrimation, Salivation |
| Why would Atropine work as an antidote for organophosphates? | Atropine is a muscarinic receptor antagonist |
| 20% of all ectoparasiticides in the UK are Pyrethroids, what is its mode of action? | Binds to and holds pre-synaptic sodium channels open so that the nerve cannot reset itself |
| What do Organophosphates and Carbamides have in common? | Their mode of action - both inhibit cholinesterase |
| Benzoyl Urea Derivatives are a group of ectoparasiticides, what is its mode of action and where does its selective toxicity stem from? | Inhibits chitin synthetase in fleas Mammals lack this enzyme |
| The newest product on the ectoparasiticide market is Metaflumizone, what is its mode of action? | Blocks voltage gated sodium channels - leading to parasite paralysis |
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