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| Questão | Responda |
| Thiazolidinediones | *Rosiglitazone* - *Pioglitazone* Starting dose: 2-4 mg QD or BID | 15 mg QD Half life: 3-4 hrs | 3-7 hrs |
| 1. Enhance insulin sensitivity in muscle &fat by increasing glucose transporter expression. 2. Increase glucose uptake in peripheral tissue. 3. Decreases hepatic gluconeogenesis. | |
| Weight gain : All of the thiazolidinediones cause weight gain. It is both dose-dependent and time-dependent | There is an increasing body of evidence suggesting that thiazolidinediones decrease bone density and increase fracture risk, particularly in women. |
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