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12994331
Acute Kidney Injury
Descrição
Medicine Mapa Mental sobre Acute Kidney Injury, criado por Nadeen Adi em 25-03-2018.
Sem etiquetas
medicine
Mapa Mental por
Nadeen Adi
, atualizado more than 1 year ago
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Criado por
Nadeen Adi
mais de 6 anos atrás
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Resumo de Recurso
Acute Kidney Injury
Structure of uriniferous tubules
Function of uriniferous tubules
Proximal convoluted tubule
Early
Late
Loop of Henle
Thin descending
water reabsorption and solutes secretion --> hyperosmotic
Thin ascending
water impermeability and solute reabsorption --> hypoosmotic
Thick ascending
Distal convoluted tubule
Early
Late + collecting duct
Regulation of body fluid osmolarity
Causes of renal impairment
Pre-renal
Intrarenal
Tubular
Drugs, heavy metals, ethylene glycol, myoglobinuria, radiocontrast dye, urate
interstitial
Drug-induced hypersensitivity (e.g. NSAIDs, penicillin, and diuretics)
glomerular
Post-renal
Pathogenesis of Acute Tubular Necrosis
Injury and necrosis of tubular epithelial cells
Necrotic cells plug tubules; obstruction decreases GFR Brown granular casts are seen in the urine
Dysfunctional tubular epithelium results in decreased reabsorption of BUN (ratio < 15) (FENa>2%) (urine osm < 500 mOsm/kg)
ischemic
Proximal tubule and medullary segment of TAL are susceptible
Nephrotoxic
Proximal tubule is susceptible
Complications of Acute Kidney Injury
Hyperkalemia
Pulmonary edema
Metabolic acidosis
Hyperphosphatemia
Management of Acute Kidney Injury
Diuretics
CA inhibitors
Act on PCT
Osmotic diuretics
Act on PCT and thick ascending
Loop diuretics
Act on thick ascending (Na-2Cl-K transporter)
Thiazides
Early DCT
K sparing diuretics
Late DCT and collecting duct
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