553509
Descrição
Mapa Mental por Sophie Barrett, atualizado more than 1 year ago
|
Criado por Sophie Barrett
quase 11 anos atrás
|
|
Allosteric Regulation by Protein Phosphorylation
- Major mechanism by which cells response to extracelluar stimuli
- e.g. hormones, light, neutrophic factors, cytokines
- Virtually every kind of neuronal
protein is regulated by
phosphorylation
- e.g. hormones, light, neutrophic factors, cytokines
- Protein Kinase transfers phosphate
groups from ATP to side chains of
serine, threonine or tyrosine on the
substrate protein.
- How is the activity of the substrate protein terminated?
- By protein phosphatase =
dephosphorylates by hydrolysis
- By protein phosphatase =
dephosphorylates by hydrolysis
- Protein Kinases may also
activate or modify other
protein kinases
downstream, or transcription
factors such as ERK
- There are 2 kinds of Protein Kinases
- 99% phosphorylate serine or threonine residues
- e.g. cAMP-dependant PKA which when
activated translocates to nucleus to
phosphorylate CREB on residue ser133.
- e.g. cAMP-dependant PKA which when
activated translocates to nucleus to
phosphorylate CREB on residue ser133.
- 1% phosphorylate tyrosine kinases (PTK)
- e.g. growth-factor receptors where ligand
binding induces dimerisation and the Tyr
residues are transphosphorylated
- e.g. growth-factor receptors where ligand
binding induces dimerisation and the Tyr
residues are transphosphorylated
- 99% phosphorylate serine or threonine residues
- How is the activity of the substrate protein terminated?
Quer criar seus próprios Mapas Mentais gratuitos com a GoConqr? Saiba mais.