Parenterals Part 2 Notes

Additives:Antimicrobials/Preservatives:Benzyl alcohol 0.5-1%Benzethonium chloride 0.01%Antioxidants:Sodium bisulphite 0.1-0.15%Sodium metabisulphite 01. 0.15%Buffers:Acetic Acid, Benzoic Acid. Citric Acid, Lactic Acid 0.1-5.0%Chelating Agents:Tetrasodium edetate 0.01%

Additives:

Water insoluble drugs:DiazepamDigoxinClonazepamPhenytoinAmidarone

Mixing of drugs that contain Calcium or Magnesium with Phosphates, Sulfates, Carbonates, Bicarbonates and Tatrates could cause precipitation.Mixing of Calcium with Ceftriaxone causes the formation of INSOLUBLE Ceftriaxone Calcium salt.

Addition of an Acidic drug solution to a solution containing Carbonate or Bicarbonate may result in CO2 Gas production.

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