10320480
Descrição
Quiz por Michael Jardine, atualizado more than 1 year ago
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Criado por Michael Jardine
quase 7 anos atrás
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Questão 1
Questão
True or false:
Cells which have entered senescence have a large, flattened morphology "like poached eggs".
Responda
- True
- False
Questão 2
Questão
Mutations in p53 and/or Rb can lead to:
Responda
-
Bypassing senescence and crisis.
-
Bypassing senescence and entering crisis.
-
Entering crisis.
-
[none of the above]
Questão 3
Questão
Cells in "crisis" have which of the following traits?
(select all that apply)
Responda
-
Massive cell death
-
Reduced cell death
-
Increased genomic stability
-
Genomic instability
Questão 4
Questão
The Hayflick limit is:
Responda
-
The number of divisions a cell can undergo before entering senescence.
-
(not this one)
Questão 5
Questão
Telomeres shorten by ~[blank_start]_____[blank_end] bp with each round of cell division.
Responda
-
5 - 15
-
50 - 150
-
500 - 1,500
-
5,000 - 15,000
-
130 - 210
-
2,000 - 40,000
Questão 6
Questão
There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
What does ALT stand for?
[blank_start]_____[blank_end]
Responda
-
Alternative Lengthening of Telomeres
Questão 7
Questão
Which [non-cancerous] cell type does NOT have shortening telomeres during replication?
Responda
-
Germ line cells
-
Stem cells
-
Cardiomyocytes
Questão 8
Questão
Telomerase is:
Responda
-
An enzyme
-
A protein
-
A molecule
Questão 9
Questão
Which telomere maintenance mechanism is used in the majority of cancers?
Responda
-
Telomerase
-
ALT
Questão 10
Questão
Telomerase can be detected using which of the following methods:
(select all that apply)
Responda
-
TRAP (Telomere Repeat Amplification Protocol) assay
-
TRF (Terminal Restriction Fragment) assay
-
APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
Questão 11
Questão
ALT can be detected using which of the following methods?
(select all that apply)
Responda
-
TRAP (Telomere Repeat Amplification Protocol) assay
-
TRF (Terminal Restriction Fragment) assay
-
APBs (ALT-associated PML Bodies)
-
C-circle assay
-
Movement of the telomere tag
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