11544540
Descrição
Quiz por Michael Jardine, atualizado more than 1 year ago
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Criado por Michael Jardine
aproximadamente 7 anos atrás
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Questão 1
Responda
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Skeletal Muscle
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Adipose Tissue
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Liver
Questão 2
Questão
Actions of Insulin. Insulin stimulates and inhibits various things. Which are STIMULATED?
Responda
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Glucose transport (muscle, adipose)
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Glycogen synthesis (muscle, adipose, liver)
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Lipogenesis (adipose, liver)
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FA transport (muscle, adipose)
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Complex lipid synthesis (muscle, adipose, liver)
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Protein synthesis (all tissues)
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Amino acid transport (all tissues)
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Protein degradation (all tissues)
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Gluconeogenesis & Glycogenolysis (liver)
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Lipolysis (adipose, muscle?)
Questão 3
Questão
Actions of Insulin. Insulin stimulates and inhibits various things. Which are INHIBITED?
Responda
-
Glucose transport (muscle, adipose)
-
Glycogen synthesis (muscle, adipose, liver)
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Lipogenesis (adipose, liver)
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FA transport (muscle, adipose)
-
Complex lipid synthesis (muscle, adipose, liver)
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Protein synthesis (all tissues)
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Amino acid transport (all tissues)
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Protein degradation (all tissues)
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Gluconeogenesis & Glycogenolysis (liver)
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Lipolysis (adipose, muscle?)
Questão 4
Questão
Definition of Insulin Resistance. There are three of them. Which is which?
“The inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilisation in an individual as much as it does in a normal population.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous insulin to alter post-translational modifications (e.g. phosphorylation) of specific proteins in tissue or cells.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous or endogenous insulin to increase glucose uptake in tissues or cultured cells.” = the [blank_start]__________[blank_end] definition.
Responda
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Clinical
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“Sometimes”
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Experimental
Questão 5
Questão
Loss of function of IR in skeletal muscle results in which of the following:
Responda
-
Reduced Skeletal Muscle glucose uptake
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Whole-body glucose intolerance and insulin resistance
Questão 6
Questão
Insulin resistance results from a fuck-up in which of the following:
Responda
-
Insulin Receptor
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Insulin Transporter
Questão 7
Questão
Loss of function of Glut4 in Skeletal Muscle results in which of the following:
Responda
-
Reduced Skeletal Muscle glucose uptake
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Whole-body glucose intolerance and insulin resistance
Questão 8
Questão
Knockout of the Insulin Receptor in ADIPOSE TISSUE is known as which of the following:
Responda
-
MIRKO
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FIRKO
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LIRKO
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AIRKO
Questão 9
Questão
True or false: FIRKO results in INCREASED insulin sensitivity in adipose tissue.
Responda
- True
- False
Questão 10
Questão
True or false: FIRKO results in DECREASED insulin sensitivity in adipose tissue.
Responda
- True
- False
Questão 11
Questão
True or false: Knockout of the Insulin Receptor in adipose tissue results in an INCREASE of weight! True? True.
Responda
- True
- False
Questão 12
Questão
Loss of function of Glut4 in ADIPOSE TISSUE results in which of the following:
Responda
-
Reduced adipocyte glucose uptake
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Reduced insulin suppression of HGP
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Increased insulin suppression of HGP
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Whole-body glucose intolerance and insulin resistance
Questão 13
Questão
LIRKO results in which of the following:
Responda
-
Loss of insulin suppression of HGP
-
Whole-body glucose intolerance and insulin resistance
Questão 14
Questão
HGP = ??
Responda
-
Hepatic Glucose Production
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HypoGonadotroPin
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Haematic Glucose Production
Questão 15
Questão
“The” Mechanism(s). “The” mechanism of insulin resistance is which of the following:
Responda
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Reduced Insulin Receptor (IR) levels
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Reduced Glut4 levels
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Inappropriate translocation of Glut4 to the plasma membrane
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Inappropriate translocation of IR to the plasma membrane
Questão 16
Questão
Insulin resistance is caused by many factors including:
Responda
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Ectopic lipid deposition
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Inflammation
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Mitochondrial oxidative stress
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