Questão 1
Questão
Which of these effects are where?
Responda
-
Skeletal Muscle
-
Adipose Tissue
-
Liver
Questão 2
Questão
Actions of Insulin. Insulin stimulates and inhibits various things. Which are STIMULATED?
Responda
-
Glucose transport (muscle, adipose)
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Glycogen synthesis (muscle, adipose, liver)
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Lipogenesis (adipose, liver)
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FA transport (muscle, adipose)
-
Complex lipid synthesis (muscle, adipose, liver)
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Protein synthesis (all tissues)
-
Amino acid transport (all tissues)
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Protein degradation (all tissues)
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Gluconeogenesis & Glycogenolysis (liver)
-
Lipolysis (adipose, muscle?)
Questão 3
Questão
Actions of Insulin. Insulin stimulates and inhibits various things. Which are INHIBITED?
Responda
-
Glucose transport (muscle, adipose)
-
Glycogen synthesis (muscle, adipose, liver)
-
Lipogenesis (adipose, liver)
-
FA transport (muscle, adipose)
-
Complex lipid synthesis (muscle, adipose, liver)
-
Protein synthesis (all tissues)
-
Amino acid transport (all tissues)
-
Protein degradation (all tissues)
-
Gluconeogenesis & Glycogenolysis (liver)
-
Lipolysis (adipose, muscle?)
Questão 4
Questão
Definition of Insulin Resistance. There are three of them. Which is which?
“The inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilisation in an individual as much as it does in a normal population.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous insulin to alter post-translational modifications (e.g. phosphorylation) of specific proteins in tissue or cells.” = the [blank_start]__________[blank_end] definition.
“The inability of exogenous or endogenous insulin to increase glucose uptake in tissues or cultured cells.” = the [blank_start]__________[blank_end] definition.
Responda
-
Clinical
-
“Sometimes”
-
Experimental
Questão 5
Questão
Loss of function of IR in skeletal muscle results in which of the following:
Questão 6
Questão
Insulin resistance results from a fuck-up in which of the following:
Responda
-
Insulin Receptor
-
Insulin Transporter
Questão 7
Questão
Loss of function of Glut4 in Skeletal Muscle results in which of the following:
Questão 8
Questão
Knockout of the Insulin Receptor in ADIPOSE TISSUE is known as which of the following:
Questão 9
Questão
True or false: FIRKO results in INCREASED insulin sensitivity in adipose tissue.
Questão 10
Questão
True or false: FIRKO results in DECREASED insulin sensitivity in adipose tissue.
Questão 11
Questão
True or false: Knockout of the Insulin Receptor in adipose tissue results in an INCREASE of weight! True? True.
Questão 12
Questão
Loss of function of Glut4 in ADIPOSE TISSUE results in which of the following:
Responda
-
Reduced adipocyte glucose uptake
-
Reduced insulin suppression of HGP
-
Increased insulin suppression of HGP
-
Whole-body glucose intolerance and insulin resistance
Questão 13
Questão
LIRKO results in which of the following:
Questão 14
Questão 15
Questão
“The” Mechanism(s). “The” mechanism of insulin resistance is which of the following:
Responda
-
Reduced Insulin Receptor (IR) levels
-
Reduced Glut4 levels
-
Inappropriate translocation of Glut4 to the plasma membrane
-
Inappropriate translocation of IR to the plasma membrane
Questão 16
Questão
Insulin resistance is caused by many factors including: