16366412
Descrição
Quiz por Berfin Miiau, atualizado more than 1 year ago
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Criado por Berfin Miiau
quase 6 anos atrás
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Questão 1
Questão
the main routes of enteral administration of drugs are
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oral
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by injection
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rectal
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per mucosa
Questão 2
Questão
Advantages of the oral route of drug administration are
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easily self-administered
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toxicity and overdose may be overcome with antidotes
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drugs avoid first-pass metabolism
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drugs go directly into the systemic circulation
Questão 3
Questão
Advantages of the rectal route of drug administration are
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suitable for vomiting patients
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suitable for children
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suitable for unconscious patients
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a way to avoid first-pass metabolism
Questão 4
Questão
Disadvantages of iv drug administration are
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a trained staff is required
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risk of bacterial contamination at the site of injection
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it is painful and stressful for the patient
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drugs undergo first-pass metabolism in the liver
Questão 5
Questão
Point out the correct statements for iv drug administration
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aqueous solutions can be administered iv
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oil solutions can be administered iv
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has the highest bioavailability
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used for treatment of life-threatening conditions
Questão 6
Questão
The subject of pharmacokinetics is
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drug absorption and distribution
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drug biotransformation
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drug elimination
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drug biological activity
Questão 7
Questão
Point out the correct statements for passive diffusion
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does not require energy
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requires energy
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involves a carrier
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drugs move from high to lower concentration
Questão 8
Questão
The diffusion of lipid soluble drugs
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depends on the charge of the drug molecule
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does not depend on the charge of the drug molecule
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is penetration through aqueous channels or pores
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is penetration through the biological membranes
Questão 9
Questão
A drug-weak acid will be absorbed
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in a medium with low pH
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in a medium with high pH
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in the stomach
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in the intestine
Questão 10
Questão
A drug-weak base will be absorbed
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in a medium with low pH
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in a medium with high pH
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in the stomach
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in the intestine
Questão 11
Questão
Point out the correct statements for active drug transport
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it is energy- dependent
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it is not energy- dependent
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requires carriers
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does not require carriers
Questão 12
Questão
Point out the correct statement for drugs bound to plasma proteins
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bound drugs are pharmacologically active
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only the unbound drugs can act on target sites in the tissues
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only the bound drugs are available to the process of elimination
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drugs may displace each other from the binding proteins
Questão 13
Questão
Drug metabolism may
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increase a drug's pharmacological activity
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decrease a drug's pharmacological activity
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change the pharmacological effects of a drug
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change the toxicity of a drug
Questão 14
Questão
first phase liver metabolism reactions include
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acetylation
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conjugation
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reduction
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oxidation
Questão 15
Questão
Second phase liver metabolism reactions include
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acetylation
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conjugation
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reduction
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oxidation
Questão 16
Questão
Phase I of drug metabolism
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may or may not involve cytochrome P450 system
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phase I reactions convert lipophilic molecules to more polar molcecules
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includes alcohol dehydrogenation, amine oxidation, hydrolysis
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consists of conjugation reactions
Questão 17
Questão
Renal excretion of a drug will be reduced if
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the drug is a weak acid and the urine is alkaline
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the drug is a weak acid and the urine is acidic
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the drug is a weak base and the urine is alkaline
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the drug is a barbiturate and the urine is alkaline
Questão 18
Questão
Drug pharmacodynamics includes
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drug effects
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mechanisms of drug action
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drug elimination
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how the organism changes drugs
Questão 19
Questão
The changes that occur due to the interaction between drug molecules and organism structures are called
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drug effect
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drug action
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adverse drug reaction
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placebo effect
Questão 20
Questão
The organism response as a result of the changes that have occured due to its interaction with the drug is called
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drug action
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drug effect
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adverse drug reaction
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placebo effect
Questão 21
Questão
What is characteristic for a drug receptor
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induces (generates) a change in organism functions
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has selectivity
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has sensitivity
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has specifity
Questão 22
Questão
Agonists are ligands which
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have affinity
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block receptors
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have intrinsic activity
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bind to the receptor
Questão 23
Questão
Antagonists are ligands which
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have strong affinity
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have intrinsic activity
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block the receptor
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do not have intrinsic activity
Questão 24
Questão
Therapeutic margin is the
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difference between maximal toxic and minimal therapeutic doses
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ratio between minimal toxic and minimal therapeutic doses
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difference between mean lethal and mean effective doses
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ratio between lethal and mean effective doses
Questão 25
Questão
Drugs' therapeutic index is the
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difference between minimal toxic and minimal therapeutic doses
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ratio between minimal toxic and minimal therapeutic doses
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difference between mean lethal and mean effective doses
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ratio between mean lethal and mean effective doses
Questão 26
Questão
Types of drug interaction are
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synergy
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antagonism
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synergy/ antagonism
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chemical antagonism (formation of complexes)
Questão 27
Questão
Potentiation can be observed during the concomitant use of
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Fentanyl and Droperidol
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Heparin and Protamine
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Amoxicillin and Clavulonic acid
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Diazepam and Flumazenil
Questão 28
Questão
Full competitive antagonist of opioid receptors, administered in acute opioid intoxication is
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Allylnormorphine
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Methadone
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Naloxone
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Flumazenil
Questão 29
Questão
Chemical antagonism or complex formation can be observed in
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Morphine and Naloxone
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Diazepam and Flumazenil
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Epinephrine and Histamine
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Iron preparation and Deferroxamine
Questão 30
Questão
Which of the following are enzyme inducers
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Phenytoin
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Phenobarbital
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Metamizol
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Metronidazole
Questão 31
Questão
Multiple drug administration could lead to
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drug tolerance
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drug dependence
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drug accumulation
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allergic reactions
Questão 32
Questão
Drug addicition/ dependence involves
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drug tolerance
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physical dependence
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psychological dependence
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allergy
Questão 33
Questão
Antiseptics are used for
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decontamination of laundry and sanitary facilities
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decontamination of skin and mucous membranes
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internal administration
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treatment of fever
Questão 34
Questão
Disinfectants are used for decontamination of
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urine, faeces and other
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mouth
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instruments
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clothing and underwear
Questão 35
Questão
Antiseptics and disinfectants are
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detergents
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barbiturates
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oxidizing agents and halogen derivatives
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phenols
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