Questão 1
Questão
In chronic lympholeukemia in the liver can be seen
Responda
-
myeloblasts
-
mature lymphocytes and single lymphoblasts
-
focal leukemic infiltrates in the portal spaces
-
leukemic infiltrates in the sinusoids
Questão 2
Questão
Chronic myeloleukemia causes the following changes in liver
Responda
-
effaced lobular structure
-
hypertrophy and hyperplasia of hepatocytes
-
atrophy of hepatocytes
-
leukemic infiltrates in the sinusoids
Questão 3
Questão
In chronic myeloleukemia we observe the following
Responda
-
long remissions even without treatment
-
extreme hepato-splenomegaly
-
anemia, hemorrhages, infections
-
splenic infarctions
Questão 4
Questão
Which are the clinical phases of chronic myeloleukemia?
Responda
-
chronic stable phase
-
accelerated phase
-
blast crisis
-
none of the above
Questão 5
Questão
In Hodgkin lymphoma, mixed cellularity type
Responda
-
there can be seen numerous eosinophils
-
we can observe areas with necrosis
-
intact histological lymph node structure
-
giant bi-nucleated cells, called ‘mirror image"
Questão 6
Questão
Plasmocytoma has the following features:
Responda
-
Reed-Sternberg tumor cells
-
Jelly-like raspberry red osteolytic bone lesion
-
The tumor cells have a large vacuolar nucleus with prominent nucleolus
-
The tumor cells have a round eccentric nucleus with a pale halo around it
Questão 7
Questão
Which of the following are examples of pathological processes in the oral cavity that can have an effect of internal organs?
Questão 8
Questão
Which avitaminosis can be associated with changes in the oral cavity?
Responda
-
vit. B6
-
vit. B12
-
vit. D
-
none of the above
Questão 9
Questão
Vitamin B12 deficiency can cause the following changes in the oral cavity
Questão 10
Questão
What type of examination you will suggest to your patient if you diagnose him/her with atrophic glossitis (Hunter’s tongue)?
Responda
-
colonoscopy
-
dermatoscopy
-
gastroscopy
-
hysteroscopy
Questão 11
Questão
If a patient with atrophic glossitis is examined with gastroscopy, what can be the findings in gastric mucosa?
Questão 12
Questão
The risk of which disease does atrophic autoimmune gastritis carry?
Questão 13
Questão
What are the usual changes in leukoplakia?
Responda
-
the epithelium is hyperkeratotic
-
acanthosis in the epithelium
-
chronic inflammation
-
dysplasia in the epithelium can be observed
Questão 14
Questão
What can we observe in leukoplakia?
Responda
-
parakeratosis
-
dysplasia
-
carcinoma in situ
-
diabetes
Questão 15
Questão
Which of the following 15 true of pleomorphic adenoma of the parotid gland
Questão 16
Questão
In chronic tonsillitis we can observe the following
Questão 17
Questão
The typical histological picture of epulis includes
Responda
-
Langhans giant multinuclear cells
-
Fresh heamorrhages and hemosiderin
-
Osteoclast-type multinuclear giant cells
-
It is a true tumor
Questão 18
Questão
Adamantinoma (amelloblastoma) is
Questão 19
Questão
Why is it necessary to comment on the presence or absence of H.pylori in gastric biopsies?
Responda
-
H. pylori is a risk factor for MALT lymphoma
-
H. pylori is a risk factor for duodenal cancer
-
H. pylori causes chronic gastritis
-
H. pylori is a severe fungal infection
Questão 20
Questão
Which of the following are possible complications of chronic gastric ulcer?
Questão 21
Questão
Which special stain help us determine the presence of H. pylori in gastric biopsies?
Responda
-
Van Gieson
-
Giemsa
-
Congo Red
-
Immunohistochemistry
Questão 22
Questão
The following changes can be observed in acute duodenal ulcer
Responda
-
fibrinoid necrosis at the ulcer base
-
inflammatory infiltrate with lymphocytes and plasma cells
-
ulceration penetrating through muscularis mucosae, reaching muscularis propria
-
it often undergoes malignant transformation
Questão 23
Questão
What histological types of gastric cancer do you recognize?
Questão 24
Questão
In phlegmonous appendicitis we can observe the following
Responda
-
peri-appendicitis
-
lymphocytic infiltration in the mucosa
-
neutrophilic infiltration throughout the thickness of the wall of the appendix
-
constriction of the blood vessels of the serosa
Questão 25
Questão
Phlegmonous appendicitis is characterized by
Responda
-
purulent exudate in the lumen
-
hypoplasia of the lymph follicles
-
hyperplastic activated lymph follicles
-
hyperemic blood vessels of the serosa
Questão 26
Questão
Gangrenous appendicitis is characterized by
Responda
-
lymphocytic infiltration of the mucosa
-
thrombosis of blood vessels
-
necrosis of the wall of the appendix
-
severe inflammation through the wall of the appendix
Questão 27
Questão
What are the causes which may lead to micro-nodular liver cirrhosis?
Responda
-
acute viral hepatitis
-
chronic viral hepatitis
-
cardiogenic shock
-
chronic alcoholism
Questão 28
Questão
Which of the types of necrosis are found in chronic active hepatitis?
Responda
-
piece-meal necrosis
-
adjacent necrosis
-
bridging necrosis
-
caseous necrosis
Questão 29
Questão
Why the level of calcium in the blood has prognostic value in acute pancreatitis?
Responda
-
calcium is deposited in the bones
-
calcium levels in the blood lower with the progression of steato-necrosis
-
calcium reacts with fatty acids to form soaps
-
it has no prognostic value
Questão 30
Questão
Some of the gross features of acute pancreatitis are
Responda
-
enlarged liver
-
steatonecrosis of the fatty tissue around and inside the pancreas
-
hemorrhages in the tissues of the pancreas
-
fibrosis in the tissues of the pancreas
Questão 31
Questão
What histological changes can be observed in chronic hepatitis?
Questão 32
Questão
Chronic cholecystitis is characterized by the following
Responda
-
often it is accompanied by cholelithiasis
-
it has no association with cholelithiasis
-
can cause adhesions
-
it is caused by viral infection
Questão 33
Questão
Which of the following can be complications caused by chronic cholecystitis?
Questão 34
Questão
After consuming poisonous mushrooms, a patient shows signs of acute liver failure with progressive reduction of the size of the liver. What process has developed in the liver?
Responda
-
acute viral hepatitis
-
massive hepatic necrosis
-
hepatocellular carcinoma
-
none of the above
Questão 35
Questão
After consuming poisonous mushrooms, a patient shows signs of acute liver failure with progressive reduction of the size of the liver. Besides liver failure, what other complication can worsen the patient’s clinical condition?
Questão 36
Questão
Which of the following can occur after a streptococcal tonsillitis?
Responda
-
post-infectious cholecystitis
-
post-infectious glomerulonephritis
-
minimal change disease of the kidneys
-
acute rheumatism
Questão 37
Questão
Which types of glomerulonephritis are clinically presented by nephritic syndrome
Responda
-
diffuse endocapillary glomerulonephritis
-
rapidly progressing glomerulonephritis
-
minimal change disease
-
membranous glomerulonephritis
Questão 38
Questão
Which types of glomerulonephritis are clinically presented by nephrotic syndrome
Responda
-
diffuse endocapillary glomerulonephritis
-
rapidly progressing glomerulonephritis
-
minimal change disease
-
membranous glomerulonephritis
Questão 39
Questão
What findings can be observed in glomerulonephritis?
Responda
-
Klebsiella
-
E.coli
-
Streptococcus
-
The urine is sterile
Questão 40
Questão
Which type of glomerulonephritis is ‘crescentic’?
Responda
-
minimal change disease
-
rapidly progressing glomerulonepbhritis
-
membranous glomerulonephritis
-
diffuse endocapillary glomerulonephritis
Questão 41
Questão
‘Big white kidney’ can be observed in the following cases
Responda
-
rapidly progressing glomerulonephritis
-
amyloidosis of the kidney
-
minimal change disease
-
nephrosclerosis glomerulonephritica
Questão 42
Questão
Which of the following histological changes are associated with tubal pregnancy?
Responda
-
chorionic villi and decidual changes of the endometrium
-
monstrous trophoblast, hydropic chorionic villi
-
hematoma in fallopian tube, chronic villi invading the muscle layer of the tube, decidual changes of the endometrium
-
cervical intraepithelial lesion, third grade
Questão 43
Questão
Which of the following histological changes are associated with mola hydatidosa?
Responda
-
chronic villi and decidual changes of the endometrium
-
monstrous trophoblast, hydropic chorionic villi without fetal blood capillaries
-
hematoma in the fallopian tube, chorionic villi invading the muscle layer of the tube, decidual changes of the endometrium
-
cervical intraepithelial lesion, third grade
Questão 44
Questão
Which of the following histological changes are associated with abortion (miscarriage)?
Responda
-
chronic villi and decidual changes of the endometrium
-
monstrous trophoblast, hydropic chorionic villi without fetal blood capillaries
-
hematoma in the fallopian tube, chorionic villi invading the muscle layer of the tube, decidual changes of the endometrium
-
cervical intraepithelial lesion, third grade
Questão 45
Questão
Specify the associated clinical symptoms in dysplasia and carcinoma in situ of the uterine cervix
Questão 46
Questão
Why if curettage from a suspected pregnancy shows only decidual changes, the gynecologist should be notified immediately?
Responda
-
there is an increased risk for endometrial carcinoma
-
there is an increased risk of associated mola hydatidosa
-
there is an increased risk of associated intraepithelial lesion of the cervix
-
there is a high risk of associated tubal pregnancy
Questão 47
Questão
Mola hydatidosa has the following characteristics
Responda
-
grossly it resembles grape-like structures
-
chronic villi have fetal capillaries
-
chronic villi are with hydropic edema
-
chronic villi lack fetal blood vessels
Questão 48
Questão
Examples of ovarian cysts are
Questão 49
Questão
Which hormones play a role in breast diseases?
Responda
-
somatotropin
-
oxytocin
-
estrogen
-
progesterone
Questão 50
Questão
How does the breast cancer metastasize?
Questão 51
Questão
Select the epithelial ovarian tumors
Responda
-
Granulosa cell tumor
-
Thecoma
-
Brenner’s tumor
-
Androblastoma
Questão 52
Questão
Which of the following are epithelial ovarian tumors?
Responda
-
Thecoma
-
Serous cystadenoma
-
Dysgerminoma
-
Brenner’s tumor
Questão 53
Questão
Which of the following are sex-cord stromal ovarian tumors?
Responda
-
granulosa cell tumor
-
thecoma
-
dysgerminoma
-
androblastoma
Questão 54
Questão
Which of the following ovarian tumors are benign?
Questão 55
Questão
Which of the following ovarian tumors are malignant?
Questão 56
Questão
In fibro-cystic breast disease we find the following
Questão 57
Questão
In fibroadenoma of the breast we find
Questão 58
Questão
Benign prostate hyperplasia is seen most commonly in
Questão 59
Questão
Prostate carcinoma is usually seen in
Questão 60
Questão
Which two markers are valuable for the diagnosis of prostate carcinoma?
Responda
-
PSA
-
HER2
-
PAP
-
Estrogen receptors
Questão 61
Questão
What pathogenetic mechanism can be used for the therapy of prostate carcinoma?
Responda
-
hormonal therapy - anti-testosterone drugs
-
hormonal therapy - anti-progesterone drugs
-
treatment with monoclonal antibodies
Questão 62
Questão
Which of the following types of cancer metastasize to bone?
Responda
-
ovarian cancer
-
renal cancer
-
breast cancer
-
thyroid gland cancer
Questão 63
Questão
Bone metastases are observed in which
Responda
-
gastric cancer
-
ovarian cancer
-
prostate cancer
-
breast cancer
Questão 64
Questão
Which of the following statements are true for Grave’s disease
Responda
-
it is the most common cause for hypothyroidism
-
exophthalmos in some patients
-
pretibial myxedema
-
usually most patients are euthyroid
Questão 65
Questão
The following is true for Grave’s disease
Responda
-
it causes hyperthyroidism
-
autoantibodies against TSH-receptors
-
affects more men than women
-
thyroid stimulating IgG is the cause
Questão 66
Questão
Histologically in Grave’s disease we can find
Responda
-
nodular colloid goiter
-
signs of thyroid hyperfunction
-
small thyroid follicles with small amounts of diluted colloid
-
many resorbtive vacuoles in the thyroid follicles
Questão 67
Questão
In nodular toxic goiter we can observe the following
Questão 68
Questão
Which of the following are renal complications of diabetes?
Questão 69
Questão
In goiter we observe
Responda
-
cystically dilated thyroid follicles
-
histological accommodation of the epithelium lining the follicles
-
papillary folds of the epithelium of the follicles
-
diluted, scarce colloid
Questão 70
Questão
Hashimoto’s thyroiditis is characterized by
Responda
-
the thyroid follicles are dilated, filled with large amounts of concentrated colloid
-
atypical looking cells called oncocytes
-
the thyroid follicles are replaced by lymph follicles
-
these lymphoid follicles have pale germinal centers
Questão 71
Questão
Pneumococcus usually causes infections of the CNS in
Responda
-
newboms
-
adults
-
teenagers
-
toddlers
Questão 72
Questão
Haemophylus influenze is the most common etiological agent for infections of the CNS in
Responda
-
newborns
-
adults
-
teenagers
-
toddlers
Questão 73
Questão
Escherichia coli is the most common etiological agent from infections of the CNS in
Responda
-
newborns
-
adults
-
teenagers
-
toddlers
Questão 74
Questão
Neisseria meningitidis is the most common etiological agent from infections of the CNS in
Responda
-
newborns
-
adults
-
teenagers
-
toddlers
Questão 75
Questão
Which of the following statements are true for tumors of the CNS?
Responda
-
metastatic tumors to the brain are more common than the primary
-
primary tumors of the CNS often metastasize outside the CNS
-
primary tumors of the CNS almost never metastasize outside the CNS
-
most important factor for the outcome is the tumor location
Questão 76
Questão
Which are the purposes of pathological autopsy?
Responda
-
to accuse the clinicians of medical malpractice
-
to establish the cause of death and the definitive diagnosis
-
to help and educate clinicians and to improve their work
-
to help the-relatives of the deceased to convict the doctors
Questão 77
Questão
Which are the conditions for an autopsy to be done?
Responda
-
death occurred in a hospital due to a disease
-
available medical history of the patient
-
presence of the treating doctor
-
all of the listed above
Questão 78
Questão
What are the characteristics of a frozen section?
Responda
-
urgent diagnosis given during an operation
-
the preparation of the tissue samples is done by a paraffin method
-
the preparation of the tissue samples is done on a freezing microtome
-
sometimes the diagnosis is not exactly clear because of the preparation method but information like “malignant tumor”, “benign tumor” or “inflammation” is given to the surgeons to know how to proceed with the operation
Questão 79
Questão
Which fixative is most commonly used?
Responda
-
Bouin solution
-
Absolute alcohol
-
Formalin 10%
-
Salts of heavy metals
Questão 80
Questão
What fixative should be used for a liver biopsy from a baby with a suspected inherited metabolic disease?
Responda
-
Formalin 10
-
1,5-4% glutaraldehyde
-
Frozen section
-
Zenker’s fixative
Questão 81
Questão
What is the role of immunohistochemical stains?
Responda
-
to give urgent answers about the diagnosis or at least orientation about the pathological process during surgery
-
to determine the histogenesis of the tumor especially in highly undifferentiated malignant tumors
-
to determine the proliferative activity and the hormonal receptors of the tumor that is highly important for the treatment
-
to help determine the cause of death
Questão 82
Questão
Cytokeratin, S-100 protein, Vimentin, Desmin, CD-20 are examples of
Questão 83
Questão
In which cases a pathological autopsy is performed?
Responda
-
when there is suspicion for diagnostic or therapeutic malpractice
-
death of a person outside the hospital
-
when there is suspicion of violent death
-
death of a patient in the hospital and when the relatives don’t ask the principal to cancel the autopsy
Questão 84
Questão
Which of the followings is not a part of performing an autopsy
Questão 85
Questão
Size, shape, elasticity, consistency, color and cut surface are characteristics of
Responda
-
microscopic examination of organs
-
gross examination of organs
-
ultramicroscopic examination of organs
-
none of the listed
Questão 86
Questão
Indicate correctly the name of the described test.
The pericardial sac is cut in Y-like section and filled with water, after that, in the presence of a witness, the right ventricle is punctured with a knife
Questão 87
Questão
Indicate correctly the name of the described test.
The pulmonary artery is cut at the place of truncus pulmonalis. Tweezers are inserted and the content of the artery is taken out for examinationion
Questão 88
Questão
Indicate correctly the name of the described test.
A pocket between the skin and the ribs is formed and is filled with water. In the presence of a witness, the thorax is punctured with a thin knife in an intercostal space
Questão 89
Questão
Where is the main accumulation of glycogen in patients with diabetes?
Responda
-
in epithelial cells of convoluted tubules and Henle’s loop
-
in epithelial cells of gastrointestinal mucosa
-
in the nuclei and in the cytoplasm of the hepatocytes
-
endothelial cells of the vessels
Questão 90
Questão
The abnormal inclusions in the hepatocytes in alpha-1 antitrypsin deficiency are composed of
Responda
-
glycogen
-
lipids
-
bile
-
proteins
Questão 91
Questão
PAS reaction with PAS control is used to distinguish
Questão 92
Questão
PAS-control is done using
Responda
-
sulfuric acid
-
hydrochloric acid
-
amylase
-
picric acid
Questão 93
Questão
What is the relation between fatty degeneration of the liver and diabetes?
Responda
-
there is no relation between them
-
patients with diabetes have increased intake of lipids to provide more energy
-
the fatty liver in diabetes is caused by increased lipolysis and increased delivery of fatty acids in the liver
-
the fatty liver leads to diabetes mellitus
Questão 94
Questão
What is android type of obesity?
Responda
-
also called “male”or “apple” type, it is the accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female” or “pear’’type, it is the accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Questão 95
Questão
What is gynoid type of obesity?
Responda
-
also called “male”or “apple” type, it is the accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female”or “pear”type, it is the accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Questão 96
Questão
What is upper type of obesity?
Responda
-
also called “male”or “apple” type, accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female”or “pear”type, it is the accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Questão 97
Questão
What is lower type of obesity?
Responda
-
also called “male” or “apple” type, it is the accumulation of lipids in the fatty cells around the shoulders, thorax and waist
-
also called “female”or “pear”’type - accumulation of lipids in the fatty cells around the hips, tights and legs
-
generalized obesity predominantly on the face, shoulders and thorax
-
generalized obesity predominantly in the tights, hips and legs
Questão 98
Questão
Which type of obesity has worse prognosis?
Questão 99
Questão
Haemolytic jaundice is characterized by the following laboratory findings:
Responda
-
increased indirect bilirubin in the serum, hypercholic stools and increased urobilinogen in the urine
-
both types of bilirubin are increased in the serum, normal colour of the stools, both bilirubin and urobilinogen are increased in the urine
-
increased direct bilirubin in the serum, hypoholic or acholic stool, increased bilirubin in the urine
-
none of the above
Questão 100
Questão
Mechanical jaundice is characterized by the following laboratory findings
Responda
-
increased indirect bilirubin in the serum, hypercholic stools and increased urobilinogen in the urine
-
both types of bilirubin are increased in the serum, normal colour of the stools, both bilirubin and urobilinogen are increased in the urine
-
increased direct bilirubin in the serum, hypocholic or acholic stools, increased bilirubin in the urine
-
none of the above