Questão 1
Questão
Parenchymal jaundice is characterized by the following laboratory findings
Responda
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increased indirect bilirubin in the serum, hypercholic stools and increased urobilinogen in the urine
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both types of bilirubin are increased in the serum, normal colour of the stocks, both bilirubin and urobilinogen are increased in the urine
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increased direct bilirubin in the serum, hypocholic or acholic stools, increased bilirubin in the urine
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none of the above
Questão 2
Questão
What is the common between fibrosis, sclerosis and cirrhosis?
Responda
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the common is the increased development of connective tissue in the organ
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the common is the lipid accumulation in the interstitium of the organ
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the common is the fibrinoid degeneration of the organ
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they are different processes and don’t have anything common between them
Questão 3
Questão
What is the clinical significance of hyalinosis of the pancreatic arteroles?
Responda
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it can cause diabetes mellitus
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it can cause pancreatic cancer
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it can cause acute pancreatitis
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hyalinosis in the pancreas is a physiological process related with ageing
Questão 4
Questão
Which stain is used to prove rheumatism in acute stage in a heart valve?
Responda
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Prussian Blue
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Toluidin-Blue
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Congo-Red
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Perls
Questão 5
Questão
Mucoid swelling can be seen in
Questão 6
Questão
The necrosis which develops at the base of an acute or chronic active ulcer in the stomach or duodenum is
Responda
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coagulative
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caseous
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fibrinoid
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liquefactive
Questão 7
Questão
Indicate the correct statement(s) for nephrosclerosis arteriolosclerotica
Responda
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it affects microscopically the afferent and efferent arterioles
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it is a result of prolonged benign hypertention
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it is a reversible process
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the process is hyalinosis
Questão 8
Questão
What are the microscopic changes seen in the brain in benign long-term hypertension?
Responda
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hyalinosis of the vessels’ walls
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edema around vessels
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accumulation of lymphocytes and plasma cells in the soft brain membranes
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developments of specific granulomas in the brain tissue
Questão 9
Questão
The gross description: thick, hard, glassy whitish depositions, non-digestable by enzymes, is indicative for
Responda
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steatonecrosis
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liquefactive necrosis
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hyalinosis
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fibrinoid deposition
Questão 10
Questão
The following diseases are examples of amyloid depositions. Find the mistake!
Responda
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Rheumatoid arthritis - AA amyloid
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Multiple myeloma - AL amyloid
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Medullary carcinoma of the thyroid gland - AA amyloid
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Alzheimer’s disease - A4 amyloid
Questão 11
Questão
‘Sago spleen and lardaceous spleen’ are
Responda
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gross appearance of the localized (sago-spleen)and generalized (lardaceous spleen) amyloidosis of the spleen
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sago spleen is amyloidosis of the spleen, while lardaceous spleen is hyalinosis of the spleen
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gross appearance of the spleen in Hodgkin’s lymphoma depending on the severity of the process
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in lardaceous spleen the amyloid is deposited in the white pulp only, while in sago spleen both white and red pulp have amyloid deposition
Questão 12
Questão
Systemic amyloidosis is proven by a biopsy from?
Questão 13
Questão
What type of calcification develops in the complicated atherosclerotic plaques?
Responda
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metastatic
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dystrophic
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metabolic
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physiological
Questão 14
Questão
Which are the causes for hypocalcaemia?
Responda
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hypoparathyroidism
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hyperparathyroidism
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intoxication with vit. D
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senile osteoporosis
Questão 15
Questão
What kind of gout can develop in a patient with leucemia?
Responda
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gout caused by excessive consumption of meat and meat products
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genetic gout caused by error in the metabolism of uric acid
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renal injury because kidneys cannot excrete the excessive amount of uric acid
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patients with leucosis never develop gout
Questão 16
Questão
Which of the following microscopic descriptions most likely suggest kidney amyloidosis? The stain is H-E in all the described specimens
Responda
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highly enlarged glomeruli, the capillary tufts filled almost all of the capsular space, capillary lumens are obliterated; pink homogeous substance is deposited also in the mesangium, in the basement membranes of the tubules and in the walls of the blood vessels
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afferent and efferent arterioles have homogenously thick walls stained in pink, some of the glomeruli look smaller, with totally effaced structure and homogenously pink in color, while others may look normal in size, or even with compensatory hypertrophy
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the interstitium shows chronic inflammatory reaction, the main change is seen in the kidney tubules which look dilated and filled with pinkish substance (these tubules look like thyroid follicles)
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many glomeruli show crescent proliferations, encompassing 2/3 f the Bowman's space; the process ends with global sclerosis of the gomerulus
Questão 17
Questão
Which of the following stain(s) is used to prove amyloidosis?
Responda
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Perls
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Congo-Red
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Van Gieson
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Methyl violet
Questão 18
Questão
Mark the correct statement(s) for kidney alymoidosis
Responda
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small, shrunken kidneys with granular surface and difficult decapsulation
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enlarged pale kidneys with waxy texture
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amyloidosis affects only one of the kidneys and doesn’t lead to chronic renal failure
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kidney amyloidosis is reversible after the treatment of the primary disease and has very good prognosis
Questão 19
Questão
Granulomatous structures, consisting of uric acid crystals, lymphocytes, macrophages, fibroblasts and giant multinucleated cells type “foreign body” are characteristic for which disease?
Responda
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tuberculosis
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sarcoidosis
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gout
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brucellosis
Questão 20
Questão
Calcification of the aorta characterizes with
Responda
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hard, rigid wall of the aorta
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soft, elastic wall of the aorta
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can be complicated with mural thrombosis and aneurysm
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is a result of metabolic calcification
Questão 21
Questão
Renal complications of gout include
Questão 22
Questão
What type of necrosis develops in the specific granuloma in tuberculosis?
Responda
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liquefactive necrosis
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coagulative necrosis
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caseous necrosis
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steatonecrosis
Questão 23
Questão
Which of the following terms are used to describe liquefactive necrosis of the brain?
Questão 24
Questão
What type of necrosis develops in the pancreas?
Questão 25
Questão
What type of necrosis develops in the specific granuloma in tuberculosis?
Responda
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liquefactive necrosis
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coagulative necrosis
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caseous necrosis
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steatonecrosis
Questão 26
Questão
Indicate the correct statement(s) for dyspasia
Responda
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it is a process of disordered cellular development
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it can develop in soft tissues
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it can develop in tissues of epithelial origin
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it is an adaptive process
Questão 27
Questão
Corpora amylacea can be seen microscopically in?
Responda
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the glands of uterine mucosa
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the glands of prostate
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the kidney’s convoluted tubules
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the follicles of thyroid gland
Questão 28
Questão
How does the hypertrophic myocardium look like grossly?
Questão 29
Questão
Hyperplasia of the endometrium can be
Questão 30
Questão
What are the complications of prostate hyperplasia?
Questão 31
Questão
Which is the main complication after squamous metaplasia of the respiratory bronchial epithelium?
Questão 32
Questão
Epistaxis and melena are examples for
Responda
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edema
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exudate
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haemorrhages
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venous congestion
Questão 33
Questão
What is hemascos?
Questão 34
Questão
What is hematemesis?
Responda
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blood vomiting
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blood in the excrements
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nose bleeding
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bleeding from the lungs
Questão 35
Questão 36
Questão
Which of the following liver changes is reversible?
Responda
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liver cirrhosis
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liver cyanosis
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nutmeg liver
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liver amyloidosis
Questão 37
Questão
Pin-point hemorrhages in the brain have usually the following pathogenesis
Responda
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per diapedesin
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per rhexin
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per diabrosin
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all of the above
Questão 38
Questão
Can thrombosis develop after death?
Responda
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yes, this is why we can see blood clots in the vessels after death
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no, thrombosis is a pathological process which develops only during lifetime
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it can develop both during life and after death
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it develops in the agony preceding death
Questão 39
Questão
What is characteristic for the post-mortem blood clot?
Responda
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dry, crumbly, layered structure
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moist, homogenous structure
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attached to the vessel’s wall
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unattached to the vessel’s wall
Questão 40
Questão
Indicate types of embolism depending on the content of embolus
Responda
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gas, air, amniotic
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thromboembolism, fat embolism
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arterial, venous
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orthograde, retrograde, paradoxal
Questão 41
Questão
Indicate types of embolism according to the way of blood flow
Responda
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gas, air, thromboembolism, amniotic, fat, parasite
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orthograde, retrograde
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arterial, venous
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paradoxical
Questão 42
Questão
Indicate types of embolism according to the character of the obturated blood vessel
Responda
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thromboembolism, amniotic, fat, gas, air embolism
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arterial
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venous
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orthograde, retrograde, paradoxical
Questão 43
Questão
Is it possible to prevent embolism?
Responda
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no, it is something we cannot control or prevent
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yes, by using anticoagulants
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yes, by exercise in bed ridden patient and early getting up from bed after operation
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yes, by staying in bed without moving after operation
Questão 44
Questão
In which organ hemorrhagic infarction can develop?
Responda
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in organs with nutritive and functional blood circulation
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in organs with nutritive circulation only
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in organs with many anastomoses
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hemorrhagic infarction can develop in any organ
Questão 45
Questão
Indicate the organ(s) where hemorrhagic infarction is possible
Responda
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liver
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heart
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lung
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intestine
Questão 46
Questão
How can we prove amniotic embolism?
Responda
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microscopically, by finding amniotic fluid in the left heart ventricle
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grossly, by finding amniotic fluid in the right heart ventricle
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microscopically, by finding amniotic particles such as lanugo, meconium etc. in the lungs
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grossly, by finding amniotic particles in the lungs
Questão 47
Questão
Why does gas embolism develop?
Responda
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because of the dissolution of blood gases, especially azotic oxide, caused by fast decompression
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because of the dissolution of blood gases, especially type caused by fast compression
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because the negative pressure of the opened blood vessels on the neck and head can lead to air entry
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because the positive pressure of the opened blood vessels on the neck and head can lead to air entry
Questão 48
Questão
What is needed for the development of hemorrhagic infarction the lung?
Responda
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double circulation of the lung
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thrombosis of a branch of a. broncialis
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thrombosis of a branch of a. pulmonalis
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chronic venous stagnation
Questão 49
Questão
What is the most common cause for the development of anemic infarction of the brain?
Responda
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thrombosis or embolism of a. cerebri anterior
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thrombosis or embolism of a. cerebri media
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thrombosis or embolism of a. cerebri posterior
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thrombosis or embolism of a. basillaris
Questão 50
Questão
What is the gross appearance of a previous anemic infarction of the brain?
Questão 51
Questão
Indicate the correct statements
Responda
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gangrene of the appendix and gangrenous appendicitis are synonyms of one same disease
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severe inflammation in gangrenous appendicitis leads to necrosis, while in gangrene of the appendix the necrosis is ischemic
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gangrene of the appendix means necrosis of the appendix while gangrenous appendicitis means severe purulent inflammation of the appendix without necrosis
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inflammation in gangrenous appendicitis is a primary process, while in gangrene the inflammation is secondary after the necrosis
Questão 52
Questão
The gross appearance “Ribbon-like fibrin deposits on the pericardium” describes
Responda
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chronic pericarditis
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fibrinous myocarditis
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fibrinous pericarditis
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acute pericarditis
Questão 53
Questão
Which are the cells that infiltrate the whole thickness of the appendix in phlegmonous appendicitis?
Questão 54
Questão
What is typical for purulent lepto-meningitis?
Responda
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hyperemic vessels, infiltration of the soft brain membranes by lymphocytes
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hyperemic vessels, infiltration of the soft brain membranes by neutrophils
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yellow-green exudate seen usually on the convex side of the brain
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clear cerebro-spinal fluid
Questão 55
Questão
Hydatid cysts affect most commonly
Responda
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the brain
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the heart
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the spleen
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the liver
Questão 56
Questão
Which is the second most commonly affected organ by hydatid cysts?
Questão 57
Questão
The following description indicates: Focal aggregates in the form of nodules of cells with phagocytic ability. The diameter of these nodules is no more than 1-2mm, in many cases they are seen only microscopically
Responda
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granulomas
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metastases
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polyps
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granulation tissue
Questão 58
Questão
What type of necrosis develops in the tuberculous granuloma?
Responda
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caseous necrosis
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liquefactive necrosis
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coagulative necrosis
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fibrinoid necrosis
Questão 59
Questão
Which of the following cells are seen in tuberculomas?
Questão 60
Questão
The giant cells type Langhans are derived from
Responda
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macrophages
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epitheloid cells
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lymphocytes
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monocytes
Questão 61
Questão
Which giant cells have specific peripheral arrangement of the nuclei like horse-shoe?
Responda
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Tuton giant cells
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Foreign body giant cells
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Langhans giant cells
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None of the above
Questão 62
Questão
In which stage of syphilis do the specific luetic granulomas develop?
Questão 63
Questão
What type of necrosis develops in luetic granulomas?
Responda
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clay-like
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caseus
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liquefactive
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coagulative
Questão 64
Questão
What type of necrosis develops in the cat-scratch disease?
Responda
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caseous
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coagulative
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liquefactive
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gummous
Questão 65
Questão
Mark the correct answer(s) about actinomycosis
Responda
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has three stages of development
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has cervical, abdominal and thoracic forms
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grossly, granular substance might be seen in the pus
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grossly, rubbery lesions with central necrosis are seen in the affected organs
Questão 66
Questão
Mark the correct diagnosis according to the following microscopic description of a granuloma.
Lack of necrosis, abundance of epitheloid cell, Langhans cells, collagen fibres, Shaumann bodies
Responda
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tuberculosis
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sarcoidosis
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rheumatism
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syphilis
Questão 67
Questão
Mark the correct diagnosis according to the following microscopic description of a grauloma:
Gummous necrosis, surrounded by epitheloid cells, single Langhans cells, abundance of plasma cells, less lymphocytes, fibroblasts
Responda
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tuberculosis
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sarcoidosis
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rheumatism
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syphilis
Questão 68
Questão
The sulfur granule is characteristic for
Responda
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tuberculosis
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felinosis
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actinomycosis
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leprosy
Questão 69
Questão
Mark the correct diagnosis according to the following microscopic description of a granuloma. Fibrinoid necrosis, surrouned by abundant lymphocytes, plasma cells, many cells of Anichkov and pathognomonic cells of Aschoff
Responda
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tuberculosis
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rheumatoid arthritis
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syphilis
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rheumatism
Questão 70
Questão
What histological changes could be seen in thyroid in Hashimoto thyroiditis
Questão 71
Questão
The histological changes in Hashimoto thyroiditis affect
Responda
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entire thyroid gland
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markedly focal
Questão 72
Questão
The thyroid follicles in Hashimoto thyroiditis are
Responda
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unchanged
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dilated
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polymorphous
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smaller
Questão 73
Questão
What is hyper-granulation?
Questão 74
Questão 75
Questão
What is a keloid?
Questão 76
Questão
Which stain can be used to prove of scarring (cicatrix) of the heart?
Responda
-
Van Gieson
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Perls
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Congo Red
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PAS
Questão 77
Questão
Which of the following could not be seen in rheumatoid nodules?
Responda
-
Fibrinoid necrosis
-
Epitheloid cells
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Langhans cells
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Lymphocytes
Questão 78
Questão
Indicate the correct statement(s) for the polyarteriitis nodosa
Responda
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it is an autoimmune disease
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it affects mostly the elastic arteries
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there is accumulation of glucosaminoglycans in the vessel walls which can be demonstrated with metachromasia with Toluidin Bleu
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the branches of the pulmonary arteries are affected
Questão 79
Questão
Anaphylactic hypersensitivity reactions are related to
Responda
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Hemolytic anemia
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Hashimoto thyroiditis
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Allergic rhinitis
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Bronchial asthma
Questão 80
Questão
Cytotoxic hypersensitivity reactions are related to
Responda
-
Hashimoto thyroiditis
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Hemolytic anemia
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Allergic rhinitis
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Nodosal poyarteriitis
Questão 81
Questão
Immune complexes mediated hypersensitivity reactions are related to
Responda
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polyartheriitis nodosa
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rheumatoid arthritis
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hemolytic anemia
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tuberculosis
Questão 82
Questão
Cell mediated hypersensitivity reactions are related to
Responda
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Tuberculosis
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Polyarteriitis nodosa
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Bronchial asthma
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Hashimoto thyroiditis
Questão 83
Questão
Which is the most common way of metastasizing of epithelial tumors?
Questão 84
Questão
What is papilloma?
Responda
-
malignant tumor of the covering epithelium
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benign tumor of glandular epithelium
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benign tumor of cover type epithelium
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benign soft tissue tumor
Questão 85
Questão
Indicate the correct characteristic(s) for papilloma
Responda
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it has tree-like stroma covered by differentiated stratified squamous epithelium
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it has tree-like stroma covered by undifferentiated squamous epithelium with signs of cell atypia
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stroma and parenchyma are difficult to distinguish
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it doesn’t have a capsule
Questão 86
Questão
What is the term used for malignant tumors of cover type epithelium?
Responda
-
adenocarcinoma
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papilloma
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carcinoma
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sarcoma
Questão 87
Questão
What is the term used for malignant tumors of glandular type epithelial origin?
Responda
-
adenocarcinoma
-
adenoma
-
carcinoma
-
carcino-adenoma
Questão 88
Questão
What is the term used for benign tumors of glandular type epithelial origin?
Responda
-
papilloma
-
adenoma
-
teratoma
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adenocarcinoma
Questão 89
Questão
Point the correct statement(s) about basal cell carcinoma
Responda
-
it develops only on the skin
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it can develop at any place with squamous epithelium
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it characterizes with early lymphogenic and hematogenic metastases
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very often it recurs at the same place after surgery
Questão 90
Questão
Keratinized squamous cell carcinoma
Responda
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develops only on the skin
-
can develop at any place with squamous epithelium
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is highly undifferenciated malignant tumor
-
is a tumor composed of more differenciated cells with keratin production
Questão 91
Questão
What kind of structures are the cancer perls?
Responda
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accumulation of keratin produced by more differentiated malignant cells originating from squamous epithelium
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pink-coloured homogenous substance located in the centre of the tumor nests
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accumulation of mucus produced by highly undifferentiated malignant cells located in the centre of the tumor nests
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pink homogenous substance that accumulates in the stroma of the tumor
Questão 92
Questão
The gross appearance of which tumor is called “ulcus rodens”?
Responda
-
squamous cell carcinoma
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melanoma
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basal cell carcinoma
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adenocarcinoma
Questão 93
Questão
Squamous cell carcinoma develops in the lung after
Questão 94
Questão
Papillary carcinoma of the urinary bladder arises from
Responda
-
squamous epithelium
-
transitional epithelium
-
glandular epithelium
-
smooth musculature
Questão 95
Questão
What is carcinoma in situ?
Responda
-
malignant tumor limited to the epithelium above the basal membrane
-
malignant tumor destroying the basal membrane but spreading no more than 5mm below it
-
benign tumor limited to the basal membrane
-
benign tumor of a great size compressing the surrounding tissues
Questão 96
Questão
Which staining is used for proving mucus production from gelatinous adenocarcinoma?
Questão 97
Questão
Pericanalicular and intracanalicular are types of
Questão 98
Questão
Kruckenberg tumors are
Responda
-
metastases from colon adenocarcinoma in the ovaries
-
metastases from pancreatic adenocarcinoma in the ovaries
-
metastases from gastric carcinoma in the ovaries
-
metastases from hepatocellular carcinoma in the ovaries
Questão 99
Questão
Pleomorphic adenoma could be seen mainly
Questão 100
Questão
Indicate the correct statements about fibroadenoma of the breast
Responda
-
capsulated and lobulated tumor
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non-capsulated malignant tumor with invasive growth
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microscopically it has two types - intracanalicular and pericanalicular
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seen in older women