Anticoagulant and Antiplatelet Drugs

Descrição

Wednesdays 2 lectures in 1 quiz.
Matthew Coulson
Quiz por Matthew Coulson, atualizado more than 1 year ago
Matthew Coulson
Criado por Matthew Coulson mais de 5 anos atrás
769
1

Resumo de Recurso

Questão 1

Questão
Which of the following are the body's natural anticoagulants?
Responda
  • Protein C
  • Protein S
  • Protein A
  • Protein G
  • Protein M
  • Antithrombin
  • Antifibrin
  • Antiprothrombinase
  • Antithrombase
  • Antithrombomodulin

Questão 2

Questão
[blank_start]Heparin[blank_end] is an anticoagulant drug which binds to one of the body's naturally occurring anticoagulants and up-regulates its action
Responda
  • Heparin

Questão 3

Questão
Which naturally occurring anticoagulant of the body does Heparin bind to and potentiate? [blank_start]Antithrombin[blank_end]
Responda
  • Antithrombin

Questão 4

Questão
Which two coagulation factors can be inhibited by unfractioned Heparin bound to antithrombin?
Responda
  • Factor Ia (Fibrin)
  • Factor IIa (Thrombin)
  • Factor IIIa
  • Factor IVa
  • Factor Va
  • Factor VIa
  • Factor VIIa
  • Factor VIIIa
  • Factor IXa
  • Factor Xa

Questão 5

Questão
The difference between unfractioned Heparin and LMWH is that LMWH can only bind to one clotting factor, which is...
Responda
  • Factor Ia
  • Factor IIa
  • Factor IIIa
  • Factor IVa
  • Factor Va
  • Factor VIa
  • Factor VIIa
  • Factor VIIIa
  • Factor IXa
  • Factor Xa

Questão 6

Questão
Which monitoring test should be used to measure the action of unfractioned Heparin?
Responda
  • Prothrombin time
  • Activated Partial Thromboplastin Time (APTT)
  • Anti-Xa Assay

Questão 7

Questão
Heparin can induce thrombocytopenia with thrombosis in long term use.
Responda
  • True
  • False

Questão 8

Questão
Which of the following complications can be caused by long term Heparin use?
Responda
  • Osteoporosis
  • Hypothyroidism
  • Iron Deficiency Anaemia
  • B12 Deficiency Anaemia
  • Acute Myeloid Leukaemia

Questão 9

Questão
Whilst Heparin reversal is usually conducted by simply stopping the heparin (short half life), in cases of major bleeding which drug can be given to reverse the antithrombin effect of heparin?
Responda
  • Protamine Sulphate
  • IV Ferrous Fibrinase
  • Prothrombin Inducing Enzyme (PTIE)
  • Coagulating Factor III (CFIII)

Questão 10

Questão
Warfarin is an anticoagulant which brings about the inhibition of [blank_start]Vitamin K[blank_end]
Responda
  • Vitamin K

Questão 11

Questão
Which clotting factors rely on Vitamin K for carboxylation?
Responda
  • Factor II
  • Factor III
  • Factor IV
  • Factor V
  • Factor VI
  • Factor VII
  • Factor VIII
  • Factor IX
  • Factor X
  • Factor I

Questão 12

Questão
Warfarin administration should be conducted at the same time every day.
Responda
  • True
  • False

Questão 13

Questão
Which testing method is used to measure the amount of Warfarin in an individual's system? (use acronym) [blank_start]INR[blank_end]
Responda
  • INR

Questão 14

Questão
A normal INR is typically between
Responda
  • 2.0-3.0
  • 1.0-3.0
  • 3.0-4.0
  • 3.0-5.0

Questão 15

Questão
Which two of the following should be given to a patient with suspect Warfarin toxicity?
Responda
  • Vitamin K orally
  • Vitamin K intravenously
  • FFP
  • Protamine Sulphate
  • Platelet transfusion

Questão 16

Questão
Rivaroxaban & Apixaban are direct inhibitors of which clotting factor?
Responda
  • Factor Ia
  • Factor IIa
  • Factor IIIa
  • Factor IVa
  • Factor Va
  • Factor VIa
  • Factor VIIa
  • Factor VIIIa
  • Factor IXa
  • Factor Xa

Questão 17

Questão
Dabigatran is another type of new anticoagulant, providing direct inhibition of ...
Responda
  • Prothrombinase
  • Thrombin
  • Prothrombin
  • Fibrinogen
  • Fibrin
  • Factor VIIIa

Questão 18

Questão
In prophylaxis of elective hip/knee replacement surgery, which would be the most appropriate choice of medication?
Responda
  • Warfarin
  • LMWH
  • Apixaban

Questão 19

Questão
Structure of an artery from deep to superficial: Tunica Intima = [blank_start]Endothelial Cells[blank_end] Tunica Media = [blank_start]Smooth Muscle[blank_end] Tunica Externa = [blank_start]Loose Fibrous Connective Tissue[blank_end] Serosa = [blank_start]Epithelial Cells[blank_end]
Responda
  • Endothelial Cells
  • Smooth Muscle
  • Loose Fibrous Connective Tissue
  • Epithelial Cells

Questão 20

Questão
Atherosclerosis is damage to the endothelium resulting in plaque formation due to recruitment of 'foamy' [blank_start]macrophages[blank_end] which are rich in [blank_start]cholesterol[blank_end]
Responda
  • cholesterol
  • macrophages

Questão 21

Questão
Which four of the following are risk factors for arterial thrombosis?
Responda
  • Diabetes
  • Hypertension
  • Smoking
  • High HDL cholesterol
  • High LDL cholesterol
  • Atrial Fibrillation
  • Alcoholism
  • Hyperthryoidism

Questão 22

Questão
When there is endothelial damage, platelets bind to the subendothelial collagen via [blank_start]Glycoprotein 1b[blank_end] and [blank_start]Von Willebrand Factor[blank_end]
Responda
  • Von Willebrand Factor
  • Platelet Adhesin
  • Platelet Derived Growth Factor
  • Protein Disulfide Isomerase
  • Glycoprotein 1b
  • Platelet Membrane Glycoprotein
  • ITGA2B
  • Human Platelet Antigen

Questão 23

Questão
After binding to the subendothelial collagen, platelets begin to attach to each other via [blank_start]Glycoprotein IIb/IIIa[blank_end] and fibrinogen
Responda
  • Glycoprotein IIb/IIIa
  • Glycoprotein Ib
  • Platelet Derived Growth Factor

Questão 24

Questão
Antiplatelet drugs: Clopidogrel = [blank_start]ADP receptor Antagonist[blank_end] Aspirin = [blank_start]Cyclo-Oxygenase Inhibitor[blank_end]
Responda
  • Cyclo-Oxygenase Inhibitor
  • ADP receptor Antagonist

Questão 25

Questão
Antiplatelets such as Abciximab inhibit [blank_start]Glycoprotein IIb/IIIa[blank_end] thus inhibiting the [blank_start]aggregation[blank_end] stage of platelet plug formation
Responda
  • aggregation
  • adhesion
  • activation
  • Glycoprotein IIb/IIIa
  • Glycoprotein Ib
  • ADP

Questão 26

Questão
Antiplatelet agents should be stopped [blank_start]7[blank_end] days prior to an elective operation.
Responda
  • 7

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