Questão 1
Questão
Which of the following are the body's natural anticoagulants?
Responda
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Protein C
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Protein S
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Protein A
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Protein G
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Protein M
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Antithrombin
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Antifibrin
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Antiprothrombinase
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Antithrombase
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Antithrombomodulin
Questão 2
Questão
[blank_start]Heparin[blank_end] is an anticoagulant drug which binds to one of the body's naturally occurring anticoagulants and up-regulates its action
Questão 3
Questão
Which naturally occurring anticoagulant of the body does Heparin bind to and potentiate?
[blank_start]Antithrombin[blank_end]
Questão 4
Questão
Which two coagulation factors can be inhibited by unfractioned Heparin bound to antithrombin?
Responda
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Factor Ia (Fibrin)
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Factor IIa (Thrombin)
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Factor IIIa
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Factor IVa
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Factor Va
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Factor VIa
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Factor VIIa
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Factor VIIIa
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Factor IXa
-
Factor Xa
Questão 5
Questão
The difference between unfractioned Heparin and LMWH is that LMWH can only bind to one clotting factor, which is...
Responda
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Factor Ia
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Factor IIa
-
Factor IIIa
-
Factor IVa
-
Factor Va
-
Factor VIa
-
Factor VIIa
-
Factor VIIIa
-
Factor IXa
-
Factor Xa
Questão 6
Questão
Which monitoring test should be used to measure the action of unfractioned Heparin?
Questão 7
Questão
Heparin can induce thrombocytopenia with thrombosis in long term use.
Questão 8
Questão
Which of the following complications can be caused by long term Heparin use?
Responda
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Osteoporosis
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Hypothyroidism
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Iron Deficiency Anaemia
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B12 Deficiency Anaemia
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Acute Myeloid Leukaemia
Questão 9
Questão
Whilst Heparin reversal is usually conducted by simply stopping the heparin (short half life), in cases of major bleeding which drug can be given to reverse the antithrombin effect of heparin?
Questão 10
Questão
Warfarin is an anticoagulant which brings about the inhibition of [blank_start]Vitamin K[blank_end]
Questão 11
Questão
Which clotting factors rely on Vitamin K for carboxylation?
Responda
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Factor II
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Factor III
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Factor IV
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Factor V
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Factor VI
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Factor VII
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Factor VIII
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Factor IX
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Factor X
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Factor I
Questão 12
Questão
Warfarin administration should be conducted at the same time every day.
Questão 13
Questão
Which testing method is used to measure the amount of Warfarin in an individual's system? (use acronym)
[blank_start]INR[blank_end]
Questão 14
Questão
A normal INR is typically between
Responda
-
2.0-3.0
-
1.0-3.0
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3.0-4.0
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3.0-5.0
Questão 15
Questão
Which two of the following should be given to a patient with suspect Warfarin toxicity?
Responda
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Vitamin K orally
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Vitamin K intravenously
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FFP
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Protamine Sulphate
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Platelet transfusion
Questão 16
Questão
Rivaroxaban & Apixaban are direct inhibitors of which clotting factor?
Responda
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Factor Ia
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Factor IIa
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Factor IIIa
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Factor IVa
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Factor Va
-
Factor VIa
-
Factor VIIa
-
Factor VIIIa
-
Factor IXa
-
Factor Xa
Questão 17
Questão
Dabigatran is another type of new anticoagulant, providing direct inhibition of ...
Responda
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Prothrombinase
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Thrombin
-
Prothrombin
-
Fibrinogen
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Fibrin
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Factor VIIIa
Questão 18
Questão
In prophylaxis of elective hip/knee replacement surgery, which would be the most appropriate choice of medication?
Questão 19
Questão
Structure of an artery from deep to superficial:
Tunica Intima = [blank_start]Endothelial Cells[blank_end]
Tunica Media = [blank_start]Smooth Muscle[blank_end]
Tunica Externa = [blank_start]Loose Fibrous Connective Tissue[blank_end]
Serosa = [blank_start]Epithelial Cells[blank_end]
Questão 20
Questão
Atherosclerosis is damage to the endothelium resulting in plaque formation due to recruitment of 'foamy' [blank_start]macrophages[blank_end] which are rich in [blank_start]cholesterol[blank_end]
Questão 21
Questão
Which four of the following are risk factors for arterial thrombosis?
Responda
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Diabetes
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Hypertension
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Smoking
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High HDL cholesterol
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High LDL cholesterol
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Atrial Fibrillation
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Alcoholism
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Hyperthryoidism
Questão 22
Questão
When there is endothelial damage, platelets bind to the subendothelial collagen via [blank_start]Glycoprotein 1b[blank_end] and [blank_start]Von Willebrand Factor[blank_end]
Responda
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Von Willebrand Factor
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Platelet Adhesin
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Platelet Derived Growth Factor
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Protein Disulfide Isomerase
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Glycoprotein 1b
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Platelet Membrane Glycoprotein
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ITGA2B
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Human Platelet Antigen
Questão 23
Questão
After binding to the subendothelial collagen, platelets begin to attach to each other via [blank_start]Glycoprotein IIb/IIIa[blank_end] and fibrinogen
Questão 24
Questão
Antiplatelet drugs:
Clopidogrel = [blank_start]ADP receptor Antagonist[blank_end]
Aspirin = [blank_start]Cyclo-Oxygenase Inhibitor[blank_end]
Questão 25
Questão
Antiplatelets such as Abciximab inhibit [blank_start]Glycoprotein IIb/IIIa[blank_end] thus inhibiting the [blank_start]aggregation[blank_end] stage of platelet plug formation
Responda
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aggregation
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adhesion
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activation
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Glycoprotein IIb/IIIa
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Glycoprotein Ib
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ADP
Questão 26
Questão
Antiplatelet agents should be stopped [blank_start]7[blank_end] days prior to an elective operation.