Clinical Immunology Final MCQs- 4th Year- PMU

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Clinical Immunology Final MCQs- 4th Year- PMU
Med Student
Quiz por Med Student , atualizado more than 1 year ago
Med Student
Criado por Med Student mais de 5 anos atrás
1322
7

Resumo de Recurso

Questão 1

Questão
Which of the following methods is suitable for detectin of serum globulins?
Responda
  • Nephelometry
  • Radial immnodiffusion by manchini
  • Turbidimetry
  • NBT-test
  • The mantoux test

Questão 2

Questão
Type II allergic reations are realized by
Responda
  • anaphylaxis
  • complement-mediated cytolysis
  • immune complexes
  • infectious immunity

Questão 3

Questão
Monoclonal antibodies are
Responda
  • pure population of immunoglobulins with same structure ant antigen specifity
  • albumins that are coded from other group of genes
  • mixed population of immunoglobulins with same structure, but different antigen specifity
  • substrate causing expression of immunoglobulins from other class in B-cells

Questão 4

Questão
Which immunological method is not proper for detecting of specific IgE
Responda
  • Immuno-enzyme(ELİSA, immuno-blot technique)
  • Classical ones(agglutination, precuipitation)
  • Floucytometry
  • Chemilluminescence

Questão 5

Questão
Low levels of IgA are found in case of
Responda
  • allergic reaction
  • chronic granulamatosis disease
  • selective IgA deficit
  • macro-globulinemia

Questão 6

Questão
Auto immune disease due to antibodies could be a result of (point the wrong answer)
Responda
  • forming of antigen-antibody complexes
  • antibodies that blockade cell receptor
  • antibody-depended cell-mediated cytotocicitty(ADCC)
  • cell-mediated reaction

Questão 7

Questão
The name of resident macrophages in liver is
Responda
  • ostephages
  • lagerhance cells
  • kupfer cells
  • microglial

Questão 8

Questão
EBV can cause
Responda
  • Hepatoma
  • Nasopharyngeal carcinoma
  • Burkit lymphoma
  • Adenocaqrcinoma pulmonis

Questão 9

Questão
Which of the following indicators is the most important in case of detecting of immune status in AIDS
Responda
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The bence-jones protein

Questão 10

Questão
System lupus erythematosus
Responda
  • is caused by mutations in ds-DNA
  • is revealed with many symptoms and affects many organs
  • is an example of T-cell mediated disease
  • is a result of generating of immune complexes

Questão 11

Questão
The opsonisation is a process of
Responda
  • Ingestion and destruction of an antigen from phagocyte
  • Of covering of antigen with antibodies in purpose to ease phagocytosis
  • Of covering of antigen with complement in purpose to ease phagoytosis
  • Obtaining of monoclonal antibodies

Questão 12

Questão
Connect with arrows allergic diseases with relevant types allergic reactions: Type [blank_start]3[blank_end] - serum-disease Type [blank_start]4[blank_end] - contact dermatitis Type [blank_start]1[blank_end] - anaphylaxis Type [blank_start]2[blank_end]- hemolytic disease of newborn
Responda
  • 3
  • 1
  • 2
  • 4
  • 4
  • 1
  • 2
  • 3
  • 1
  • 2
  • 3
  • 4
  • 2
  • 1
  • 3
  • 4

Questão 13

Questão
The mature B-lymphocytes expresses onto their surface
Responda
  • IgM and IgD
  • IgM and IgA
  • IgD and IgE
  • IgG and IgD

Questão 14

Questão
The lymphocyte infiltration of thyroidea is typical for
Responda
  • The hashimoto thyroitidis
  • Euthyroid struma
  • Hemolytic anemia
  • Tuberculosis

Questão 15

Questão
The electrophoresis is
Responda
  • radial immunodiffusion in gel
  • separation of molecules in electric field
  • complement fixation reaction
  • electroimmunodiffusion

Questão 16

Questão
I type allergic reactions are
Responda
  • Immunocomplex
  • Cytotoxic
  • IgE mediated
  • Cell mediated

Questão 17

Questão
Connect with arrows autoimmune diseases from the left side with relevant characteristics from the right side: wide with relevant characteristics a. Multiple sclerosis [blank_start]6[blank_end] b. SLE [blank_start]4[blank_end] c. Myasthenia gravis [blank_start]5[blank_end] d. Pernicious anemia [blank_start]1[blank_end] e. Hashimoto thyoiditis [blank_start]2[blank_end] f. Hemolytic anemia [blank_start]3[blank_end] 1. autoantibodies against parietal cells of stomach ans intrinsic factor and as a result of this doesn't absorb Vitamin B12 2. autoantibodies against thyroglobuline and thyroid peroxidase 3. antibodies against epitopes of red blood cells 4. antibodies against nucleus antigens 5. antibodies against acetylcholine 6. antibodies against morbidly antigens in liquor and serum, depressed reactions of delayed type hypersensitivity against measles antigens
Responda
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 4
  • 1
  • 2
  • 3
  • 5
  • 6
  • 5
  • 1
  • 2
  • 3
  • 4
  • 6
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 2
  • 1
  • 3
  • 4
  • 5
  • 6
  • 3
  • 1
  • 2
  • 4
  • 5
  • 6

Questão 18

Questão
The monoclonal antibodies, connected with diphtheria toxin could be used for
Responda
  • tumour diagnosis
  • immunostimulation
  • immunosupperession
  • immunotherapy of tumors

Questão 19

Questão
The defensins are
Responda
  • growth factors
  • antimicrobial peptides in granules of neutrophils
  • cytokines-mediators for immune response

Questão 20

Questão
What is the mechanism of III type allergic reactions
Responda
  • anaphylaxis
  • complement-mediated cytolsis
  • immune complexes
  • infectious immunity

Questão 21

Questão
Which of the following tumour markers are connected with melanoma maligna?
Responda
  • CA-15-3
  • gp 120
  • S100B
  • MART-1Melan A

Questão 22

Questão
Immuno-scintigraphy uses monoclonal antibodies against tumour antigen connected with
Responda
  • FITC
  • Rhodamine
  • Iodine 131, technetium
  • Enzyme

Questão 23

Questão
INF-γ is produced by
Responda
  • Activated T lymphocytes
  • Fibroblasts
  • B-lymphocytes
  • Leucocytes

Questão 24

Questão
What kind of auto-antibodies we find in patients with insulin-depended sugar diabetes?
Responda
  • Nucleus
  • Thyroid microsomes
  • IgG molecules
  • Island cells of pancreas

Questão 25

Questão
Rejection of a transplantant due to pre-forming antibodies in recipient is defined as
Responda
  • Hyper acute rejection
  • Accelerated
  • Acute
  • Chronic

Questão 26

Questão
What of the following possesses the most expressed oncogenic potential
Responda
  • Influenza virus type A
  • Ebola virus
  • EBV
  • Polioviruses 1,2 ,3
  • HPV

Questão 27

Questão
Is the following correct? Active immunity is a nospecific and is an ancient form of defense and lower degree of effectiveness?
Responda
  • True
  • False

Questão 28

Questão
Type IV allergic reactions are realized by means of
Responda
  • anaphylaxis
  • complement-mediated cytolysis
  • immune reactions
  • infectious immunity

Questão 29

Questão
True hypersensitivity reactions start usually after
Responda
  • 15-30 minutes
  • 48 hours

Questão 30

Questão
Which of the following characteristics does not belong to the Burkit lymphoma?
Responda
  • T-cell neoplasma
  • Is a non-hodgkin lymphoma
  • Has a connections with EBV
  • Is a B-cell lymphoma

Questão 31

Questão
Antigen presenting cells are
Responda
  • Dendrite cells and macrophages
  • T-lymphocytes
  • B-lymphocytes
  • Polymorphy-nuclear cells

Questão 32

Questão
We could use the mantoux test in diagnosis of (point two diseases) a- [blank_start]Tuberculosis[blank_end] b- [blank_start]Leprosy[blank_end]
Responda
  • Tuberculosis
  • Leprosy

Questão 33

Questão
Which of the following factors belong to the innate immunity?
Responda
  • Phagocytosis
  • T-lymphocytes
  • Complement, mucin, a-and b inferferons
  • Antibodies
  • Skin, mucus, normal flora
  • B-lymphocytes

Questão 34

Questão
What we could use as a subsrrate for detection of antinuclear antibodies throguh IFA?
Responda
  • rat liver
  • rat kidney
  • rat stomach
  • hep2 cell line

Questão 35

Questão
Which of the pointed immunological parameters is most important for detection of multiple myleoma?
Responda
  • NBT test
  • Anti-DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Questão 36

Questão
The most popular techniques for detection of antinuclear antibodies are
Responda
  • Agglutination
  • Indirect immunofluorescence
  • Neutralization test
  • The complement fixation test
  • ELISA
  • Direct immunofluorescence

Questão 37

Questão
CD3 molecule is a marker for
Responda
  • NK cells
  • Macrophages
  • Immunocompetent T lymphocytes
  • Mature B-lymphocytes

Questão 38

Questão
The accelerated reaction for rejection of transplantant is revealed
Responda
  • Intra-operative or immediately after operation
  • 24-to 72 hours after transplantation
  • Till the third month
  • 3 month after the transplantation

Questão 39

Questão
which of the following immunological indexes ids the most important for patients with chronic granulomatous disease?
Responda
  • NBT test
  • Anti DNA antibodies
  • CD4/CD8 index
  • The Bence-jones protein

Questão 40

Questão
CEA is increased in case of
Responda
  • nasopharyngeal carcinoma
  • the Burkit lymphoma
  • gatro-intestinal tumors
  • smokers

Questão 41

Questão
Which of the following is connected with damage of humoral immunity?
Responda
  • Di-George sydrome
  • Agamaglobulinemia of Bruton
  • Chronic candidosis of skin and mucus
  • Angioedema hereditaria

Questão 42

Questão
How many are complement activating ways?
Responda
  • one
  • three
  • two
  • four

Questão 43

Questão
The complement activation occurs via three pathways which are: 1. [blank_start]Classical[blank_end] pathway 2. [blank_start]Alternative[blank_end] pathway 3. [blank_start]Lectin[blank_end] pathway
Responda
  • Classical
  • Alternative
  • Lectin

Questão 44

Questão
The “respiratory burst" is related to
Responda
  • Humoral immunity
  • Cellular immunity
  • Phagocytosis
  • NK-cells function

Questão 45

Questão
The immune competence of T-lymphocytes is acquired in
Responda
  • Thyroidea
  • Bone marrow
  • Thymus
  • MALT

Questão 46

Questão
What expresses the CD8 molecule?
Responda
  • Macrophages
  • Antigen presenting cells
  • Cytotoxic T-lymphocytes
  • T- suppressors

Questão 47

Questão
What is human cell receptor for human immunodeficiency virus (HIV)?
Responda
  • CD3 molecule
  • CD8 molecule
  • CD4 molecule
  • CD19 molecule

Questão 48

Questão
Point the WRONG answer: Gamma interteron is produced by:
Responda
  • Non-activated macrophages and mastocytes
  • Leucocytes and Fibroblasts
  • Activated macrophages and NK cell
  • Lymphocytes

Questão 49

Questão
The determination of functional activity of the complement might be done by
Responda
  • Immune histochemical methods
  • Reaction neutratisation
  • CH50 test
  • Micro haemagglutination

Questão 50

Questão
CD4 molecule is situated on the surface of the
Responda
  • Monocytes
  • T-helpers
  • Cytotoxic T-lymphocytes
  • Plasmocytes

Questão 51

Questão
The presence of the antigen together with the MHC-II class molecules is realized by
Responda
  • Dendrite cells and macrophages
  • Cytotoxic T-lymphocytes
  • B-lymphocytes
  • Plasmocytes

Questão 52

Questão
A B-cell can synthesise some different antibodies with different species of the antigen
Responda
  • True
  • False

Questão 53

Questão
After the antigen stimulus the mature B-lymphocytes are transformed into
Responda
  • cytotoxic cell
  • immunocompetent cell
  • plasmocyte

Questão 54

Questão
What tests are for evaluation of the phagocytic activity?
Responda
  • Flow cytometry of detection of oxidative burst
  • Serum levels of immunoglobulins
  • CD4/CD8 index
  • NBT test

Questão 55

Questão
Paraproteinemias are detected in
Responda
  • Multiple myeloma
  • Reiter's Syndrome
  • Waldenstrom macroglobulinemia
  • Chronic lymphoid leukemia
  • SLE

Questão 56

Questão
Last cells, incapable to divide are
Responda
  • Plasmocytes
  • Neutrophils
  • T-lymphocytes
  • B-Iymphocytes

Questão 57

Questão
What do the mature B-lymphocytes express on their surface?
Responda
  • lgM and IgD
  • IgD ant IgE
  • IgM and IgA
  • IgG and IgD

Questão 58

Questão
How do CD8 eliminate their targets?
Responda
  • after recognition of antigen, connected with MCH-I class molecule
  • after recognition of antigen connected with MCH-II class molecule
  • via activation of an alternative way of complement
  • due releasing of interferon

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