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IBS Set 4 Quiz - Pharmacology

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Quiz por . ., atualizado more than 1 year ago
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Resumo de Recurso

Questão 1

Questão
Parenteral administration of drugs describes what?
Responda
  • Orally/Rectally
  • Intravenously/Intramuscularly
  • Inhaled

Questão 2

Questão
Percutaneous administration of drugs describes what?
Responda
  • Inhaled
  • Orally/Rectally
  • Intravenously/Intramuscularly

Questão 3

Questão
Enteral administration of drugs describes what?
Responda
  • Orally/Rectally
  • Intravenously/Intramuscularly
  • Inhaled

Questão 4

Questão
What is an advantage of the parenteral route of administration?
Responda
  • Easy to administer on unconscious patients
  • Reaches the blood stream first and avoids first pass metabolism

Questão 5

Questão
What is an advantage of percutaneous administration of drugs?
Responda
  • Easy to administer on unconscious patients
  • Reaches the blood stream first and avoids first pass metabolism

Questão 6

Questão
Repeated doses of general anaesthetic such as thiopental can cause a fatal dose because of accumulation, or "tissue binding" in adipose tissue.
Responda
  • True
  • False

Questão 7

Questão
1st pass metabolism describes what phenomenon?
Responda
  • When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly reduced because it is metabolised by the liver before it reaches the systemic circulation.
  • When the concentration of a drug available to the systemic circulation (it's bioavailability) is significantly increased because it is metabolised by the liver before it reaches the systemic circulation.

Questão 8

Questão
1st pass metabolism can be useful for activating pre-cursor drugs such as L-dopa into dopamine.
Responda
  • True
  • False

Questão 9

Questão
Steady state in pharmacology describes what?
Responda
  • Drug absorption = Drug elimination
  • Drug absorption > Drug elimination
  • Drug absorption < Drug elimination

Questão 10

Questão
What is the plasma half life of a drug?
Responda
  • The time for half of the drug to be eliminated from the blood
  • The time it takes for a drug to lose half of its pharmacological activity

Questão 11

Questão
What is meant by the hydrophobic effect?
Responda
  • Amino acids with non-polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
  • Amino acids with non-polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.
  • Amino acids with polar (hydrophobic) groups arrange themselves on the inside of a protein and vice versa.
  • Amino acids with polar (hydrophilic) groups arrange themselves on the inside of a protein and vice versa.

Questão 12

Questão
Haemoglobin in sickle cell is dysfunctional as a result of an incorrect hydrophobic effect.
Responda
  • True
  • False

Questão 13

Questão
What is the primary structure of a protein?
Responda
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Questão 14

Questão
What is the secondary structure of a protein?
Responda
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Questão 15

Questão
What is the tertiary structure of a protein?
Responda
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Questão 16

Questão
What is the quaternary structure of a protein?
Responda
  • Sequence of amino acids
  • Folding into an alpha helix or beta pleated sheet
  • Folding of a polypeptide chain and addition of prosthetic groups
  • Many polypeptide chains

Questão 17

Questão
The two weakly ionising groups of an amino acid are?
Responda
  • Amino group
  • Carboxyl group
  • R group

Questão 18

Questão
With a pKa value of 9.7, and the equation NH3+ -> NH2 + H+ , at pH 9 what species will dominate?
Responda
  • NH2 + H+
  • NH3+

Questão 19

Questão
What graph correctly depicts the dose response curve?
Responda

Questão 20

Questão
Response is proportional to occupancy
Responda
  • True
  • False

Questão 21

Questão
The maximum response cannot be attained when a competitive reversible antagonist is present.
Responda
  • True
  • False

Questão 22

Questão
In the presence of a competitive reversible antagonist, how is the dose response curve shifted?
Image:
a652a37c-f89e-4d0e-9434-ddb8048c55c8 (image/png)
Responda
  • Left
  • Right

Questão 23

Questão
An irreversible antagonist means that the maximum response can never be reached.
Responda
  • True
  • False

Questão 24

Questão
How is the dose response curve shifted in the presence of an irreversible antagonist?
Image:
6bb22cbe-21da-4f09-9b52-8bf08c71fca6 (image/png)
Responda
  • Down
  • Up

Questão 25

Questão
Irreversible antagonists cause a decrease in the maximal response when spare receptors are not present.
Responda
  • True
  • False

Questão 26

Questão
Prolonged exposure to a drug reduces the bodies response to it.
Responda
  • True
  • False

Questão 27

Questão
Without spare receptors, non-competitive antagonists can reduce the maximal response (Emax).
Responda
  • True
  • False

Questão 28

Questão
When a non-competitive antagonist is used in the presence of spare receptors, the dose response curve shifts left.
Responda
  • True
  • False

Questão 29

Questão
Non-competitive antagonists do not compete for the agonist binding site.
Responda
  • True
  • False

Questão 30

Questão
Irreversible antagonists reduce the number of available receptors.
Responda
  • True
  • False

Questão 31

Questão
The dose response curve of an irreversible agonist is shifted down because the maximal response is decreased.
Responda
  • True
  • False

Questão 32

Questão
Select common ways that cells regulate their functions via receptors
Responda
  • Altering membrane potential
  • Phosphorylating enzymes
  • Altered gene expression in cells

Questão 33

Questão
An integral tyrosine kinase can be activated and then phosphorylates a target molecule such as an enzyme.
Responda
  • True
  • False

Questão 34

Questão
Lipophobic molecules can cross the PM and NM and bind to steroid receptors e.g. to boost transcription.
Responda
  • True
  • False

Questão 35

Questão
G-protein coupled receptors have ATPase activity that turns their activity off.
Responda
  • True
  • False

Questão 36

Questão
Cytokine receptors activate JAK that can phosphorylate targets and lead to signal pathways.
Responda
  • True
  • False

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