323663
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
aproximadamente 11 anos atrás
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Questão 1
Questão
Which Gprotein causes the activation Phospholipase CBeta?
Responda
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Gq
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Gs
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Gi
Questão 2
Questão
How is Phospholipase CBeta activated?
Responda
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By GTP binding to the alpha subunit of the Gq protein
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By ATP binding to the alpha subunit of the Gq protein
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By GMP binding to the alpha subunit of the Gq protein
Questão 3
Questão
What is broken down by phospholipase CBeta?
Responda
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Phosphatidynositol 4,5 bisphophate
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Phosphatidynositol 3,5 bisphophate
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Phosphatidynositol 2,4 bisphophate
Questão 4
Questão
Which product of the PCbeta pathway causes the release of calcium from the ER?
Responda
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IP3
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Diacylglycerol
Questão 5
Questão
What role(s) does the released Ca perform?
Responda
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Activates protein kinase C
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Activates protein kinase B
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Activates various Ca dependent protein kinases
Questão 6
Questão
What residues are phosphorylated by the protein kinases activated by this pathway?
Responda
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Serine
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Threonine
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Tyrosine
Questão 7
Questão
Which subunit of Protein Kinase C contains the pseudosubstrate domain?
Responda
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PS
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C1A
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C4
Questão 8
Questão
What is the function of subunut C1A
Responda
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DAG binding site
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Calcium binding site
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Phosphatidyl serine binding site
Questão 9
Questão
Do Ca 2+ and phosphatidyl serine bind to subunit C2?
Responda
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Yes
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No
Questão 10
Questão
Which subunits are part of the catalytic domain?
Responda
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C1A
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C3
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C4
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PS
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C5
Questão 11
Questão
ATP binds to C2, True or False?
Responda
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True
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False
Questão 12
Questão
When IP3 causes the increase in cytosolic calcium, what happens to protein kinase C?
Responda
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It moves to the membrane and binds with DAG
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It remains in the cytoplasm and binds with DAG
Questão 13
Questão
Once protein kinase C has bound to DAG in the membrane, what does it then bind to to release the pseudosubstrate from its active site?
Responda
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Phosphatidylserine
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Phosphatidylglycine
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Phosphatidylglutamate
Questão 14
Questão
Which of the following is a tumor promoting agent?
Responda
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Phorbol ester
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Orphol ester
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Phenyl ester
Questão 15
Questão
How do tumor promoting agents effect Phospholipase CBeta?
Responda
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They bind without being degraded, so it becomes hyperactive
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They stop the alpha subunit binding, so it becomes unreactive
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They cause the multiplication of the number of PCbeta enzymes in the cell, causing hyperactivity
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