39211836
Descrição
Quiz por Leon Schwarze, atualizado 6 meses atrás
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Criado por Leon Schwarze
6 meses atrás
|
|
Questão 1
Questão
Definition KPC
Klebsiella Pneumoniae carbapenemase
Responda
- True
- False
Questão 2
Questão
Beta-lactams don’t work on atypical bacteria, because:
Atypical bacteria lack cell walls and thus are naturally resistant against all beta-lactams
&
because beta-lactams act by preventing the synthesis of the bacterial cell wall.
Responda
- True
- False
Questão 3
Questão
Which bacteriaare intrinsically resistant to vancomycin (glycopeptide)
Responda
-
a) Lactobacillus
-
b) Erysipelothrix
-
c) a+b
Questão 4
Questão
Resistance to [blank_start]Quinolones[blank_end]. is caused by chromosomal mutation in structural genes of DNA gyrase and topoisomerase IV
Responda
-
Quinolones
Questão 5
Questão
Which Bacteria can become resistant to Macrolides
Responda
-
Staphylococcus
-
Streptococcus
Questão 6
Questão
In gentamicin active efflux of drug in bactericides
Responda
- True
- False
Questão 7
Questão
Chloramphenicol is the enzymatic modifcation of acetyltransferase-
Responda
- True
- False
Questão 8
Questão
Which resistant bacterias are enzymatic
Responda
-
PRSA
-
HLAR
-
MRSA
-
ESBL
-
KPC
Questão 9
Questão
Resistant bacterias witch are NOT enzymatic but have an altered target site
Responda
-
MLSb
-
PRSP
-
MBL
-
MRSA
-
VRE
Questão 10
Questão
MRSA ?
[blank_start]methicillin[blank_end] [blank_start]resistant[blank_end] [blank_start]staphylococcus[blank_end] [blank_start]aureus[blank_end]
resistant against all beta-lactams and inhibitors, excluding 5th generation of cephalosporins
Responda
-
methicillin
-
resistant
-
staphylococcus
-
aureus
Questão 11
Questão
Which Bacteria are resistant against Beta Lactams
Responda
-
MBL - Metallobetalactamases
-
KPC - Klebisella pneumonia carbapanemase / CPE - Carbapanemase producing Enterobacteriaceae
-
MRSA (with exception to 5th gen cephalosporin)
-
Mycoplasma and Chlamydia
-
Chlamydia + VRE - Vancomyocinr resistant enterococcus
Questão 12
Questão
Which of the following phenotypes relate to the enzyme production
Responda
-
VRE
-
ESBL - positive
-
HLAR
-
PRSP
-
MBL - positive
-
NDM - positive
Questão 13
Questão
Which of the following phenotypes relate to the enzyme production
Responda
-
VRE
-
ESBL
-
HLAR
-
PRSP
-
MBL
-
Ch-
Questão 14
Questão
[blank_start]PRSP[blank_end]: Resistant to narrow penicillin & possibly 3rd gen cephalosporin
Responda
-
PRSP
-
MRSA
-
HLAR
Questão 15
Questão
Which Bacteria are resistant to narrow penicillin
Responda
-
a) E.coli
-
b) PRSP
-
c) MRSA
-
d) b+c
-
e) All of the mentionend
Questão 16
Questão
Which of the following may become resistent (aquired) to tigecycline
1) E.coli
2) P.aeruginosa
3) Acinetobacter baumannii
4) proteus mirabilis
5) K. pneumoniae
Responda
-
a) 1,2,3,5
-
b) 1,3,5
-
c) 2,3
-
d) 3,4
-
e) 4,5
Questão 17
Questão
Modification of an existing PBP´s through recombination indicates
Responda
-
a) MRSA
-
b) VRE
-
c) NDM+
-
d) PRSP
-
e) PRSA
Questão 18
Questão
Which phenotype refers to MSSA
Responda
-
a) resistant to all beta-lactams excluding Vth generation of cephalosporin
-
b) resistant to all beta lactams including Vth generation of cephalosporin
-
c) resistant to methicillin, susceptible to oxacillin and carbapenems
-
d) susceptible to all beta lactams, excluding narrow spectrum penicillins
-
e) susceptible to all beta lactams including narrow spectrum penicillins
Questão 19
Questão
Which of the drugs are pumped out by efflux
Responda
-
a) Tetrayclines
-
b) Vancomycin
-
c) Tigecycline
-
d) a+c
-
e) all of the mentionend
Questão 20
Questão
Choose correct Statement
Responda
-
The class C beta-lactamases are primarily cephalosporinases and are encoded on bacterial chromosomes
-
Class B carbapenemases are i.A. New Delhi metallo-beta-lactamases
-
Colistin binds to the membrane instead of penetrating it
-
Tigecycline may be affected by efflux or enzymatic modification
-
Active efflux of gentamycin is commonly observed in Bacteroides fragilis
Questão 21
Questão
Which of the following phenotypes relate to the enzyme production:
1. VRE
2. ESBL-positive
3. HLAR
4. PRSP
5. MBL-positive
6. NDM-positive
Responda
-
a) 1,2,3,5
-
b) 2,4
-
c) 2,5
-
d) Only 4
-
e) 2,3,5,6
Questão 22
Questão
What is an “intrinsic resistance”
[blank_start]Natural resistance[blank_end]
definition they want us to write:
Bacteria is born with such a resistance, “comes into the world”
Responda
-
Natural resistance
Questão 23
Questão
Explain the abbreviation “NDM”: [blank_start]New Delhi[blank_end] [blank_start]Metallo-beta lactamase[blank_end]
Responda
-
New Delhi
-
Metallo-beta lactamase
Questão 24
Questão
Resistance to this drug results from [blank_start]acetyltransferase[blank_end] which catalyzes its acetylation. This characteristic indicates:
Chloramphenicol
Responda
-
acetyltransferase
Questão 25
Questão
Class B ß-Lactamases:
Responda
-
a.) Are Zinc dependent Metalloenzymes
-
b.) Have Broad spectrum of action
-
c.) SHV-1 and TEM-1 are Major examples
-
d.) a+b
-
e.) None of the above
Questão 26
Questão
Tetracycline resistance develops with which of the following mechanisms?
Responda
-
a) Decreased penetration into the bacterial cell
-
b) Active efflux of the drug
-
c) Alteration of the ribosomal target site
-
d) a+c
-
e) all of the above
Questão 27
Questão
Natural resistance is observed in:
Responda
-
a) Pediococcus, Leuconostonc, Erysipelothrix, Lactobacillus
-
b) E.Coli, Klebsilla
-
c) Staphylococci
-
d) a+b
-
e) none of the above
Questão 28
Questão
Pseudomonoas aeruginosa is intrinsically resistant to:
Responda
-
a) Tigecycline
-
b) Tobramycin
-
c) Meropenem
-
d) Ceftazidime
-
e) Sulphonamides
-
f) d+e
Questão 29
Questão
Resistance through enzymatic modification of the drug is observed in:
Responda
-
a. Clindamycin – Str. Pyogenes
-
b. ß-Lactams – chlamydia
-
c. E. coli – glycopeptides
-
d. Isoniazid – mycobacteria
-
e. None of the above
Questão 30
Questão
Strict anaerobic bacteria have an intrinsic resistance to:
Responda
-
d. Clindamycin
-
e. None of the above
-
c. Metronidazole
-
b. Ampicillin
-
a. Gentamicin
Questão 31
Questão
Which of the following phenotypes (resistance) matches the description for MRSA
Responda
-
a. Penicillin G, ureidopenicillin, imipenem, vancomycin – susceptible
-
b. Vancomycin, imipenem – susceptible; penicillin, 1st and 2nd Generation cephalosporins – resistant
-
c. Vancomycin – susceptible; penicillin, Cephalosporin, carbapenem – resistant d. Penicillin – susceptible; vancomycin, carbapenem, cephalosporin – resistant
-
d) a+b
-
e) none
Questão 32
Questão
Partial modification of a PBP through recombination in:
Responda
-
e. All of the above
-
d. Klebsiella pneumoniae
-
c. MRSA-acquisition of new pbp
-
b. Streptococcus pneumoniae
-
a. Escherichia Coli
Questão 33
Questão
Which of the following haven an aquired resistance to ß-Lactams
Responda
-
a) MRSA
-
b) PRSP
-
c) ESBL
-
d) a+b
-
e) All of the above
Questão 34
Questão
Strict anaerobic bacteria are resistant to:
Responda
-
a) Gentamicin
-
b) Penicillin
-
c) Metronidazole
Questão 35
Questão
Which of the following resistance phenotypes are associated with PBP modification
Responda
-
a) NDM
-
b) ESBL
-
c) PRSP
-
d) KPC
-
e) MRSA
-
f) c+e
Questão 36
Questão
Choose true Statement
Responda
-
a) Efflux of aminoglycosides occurs rarely in gram negative bacteria
-
b) Penicillin G is inactivated with gastric acid
-
c) Gram negative bacteria rapidly develop resistance against beta lactams by production
-
d) all of the above
Questão 37
Questão
Intrinsic Resistance to sulphonamides
Responda
-
a) Pseudomonas aeruginosa
-
b) Nocardia
-
c) Chlamydia
-
d) B+c
Questão 38
Questão
HLAR - [blank_start]high level[blank_end] [blank_start]aminoglycoside[blank_end] [blank_start]resistance[blank_end]
Responda
-
high level
-
aminoglycoside
-
resistance
Questão 39
Questão
MRSA - [blank_start]methicillin[blank_end] [blank_start]resistant[blank_end] [blank_start]staphylococcus[blank_end] [blank_start]aureus[blank_end]
Responda
-
methicillin
-
resistant
-
staphylococcus
-
aureus
Questão 40
Questão
Choose true combination of drugs resistance against
Responda
-
a) Rifampin – rna polymerase
-
b) Levofloxacin – mosaic PBP
-
c) Erythromycin – enzyme modification
-
d) Penicillin G- enzyme modification
-
e) a+c+d
Questão 41
Questão
Resistance to this drug with protein production similar to elongation factor that protects 30S ribosomal subunit indicates the resistance to?
Responda
-
a) Penicillin
-
b) Azithromycin
-
c) Tetracyclines
-
d) Rifampin
Questão 42
Questão
Acquired resistance to penicillin G is observed in
Responda
-
a) Streptococcus pyogenes
-
b) E.coli
-
c) Streptococcus pneumonia
-
d) a+c
Questão 43
Questão
Give two examples of mechanisms of resistance with change of target site?
Responda
-
PRSP
-
MRSA
Questão 44
Questão
Give 2 groups of drugs that are elimanted by efflux group
Responda
-
Quinolones
-
Tetracycline
Questão 45
Questão
Resistance to aminoglycosides
Responda
-
Decreased permeability
-
Enzymatic modification
Questão 46
Questão
Erythomyocin is not active against K.Pneumoniae
Responda
- True
- False
Questão 47
Questão
Which of the following resistant phenotypes are associated with aminoglycosides modyfying enzyme production
HLAR
Responda
- True
- False
Questão 48
Questão
Choose True sentence
Responda
-
a) Bacteria can become resistant to β-lactam antibiotics hydrolysis of the antibiotic by bacterial enzymes
-
b) Exclusion of B-lactamases in treatment of infection caused by non fermented process also due to decreased permeability of membrane
-
c) Enterobacteriaceae develop resistance to cephalosporins also due to the enzymes production
-
d) a+c
Questão 49
Questão
Intrinsic resistance to Linezolid - Escheria
Responda
- True
- False
Questão 50
Questão
Resistance to Metronidauole due to
Responda
-
Rescreased uptake of antibiotic
-
Elimination of cytotoxic compound before they reach DNA
Questão 51
Questão
Intrinsic resistance to Penicillin G - S pyogenes
- Chlamydia
Responda
- True
- False
Questão 52
Questão
Pumped out by efflux pump
Responda
-
Tetracyclines
-
Aminoglycosides
Questão 53
Questão
Which phenotype refers to MRSA?
Responda
-
a.) resistant to all beta lactams including vth generations of cephalosporins
-
b.) resistant to all beta lactams excluding vth generations of cephalosporins
-
c.) resistant to methicillin,susceptible to oxacillin and carbapenem
-
d.) resistant to beta lactams,resistant to vancomycin,susceptible to monobactams
-
e.) none of the mentioned
Questão 54
Questão
Enterococcus gallinarum and casseliflavus are instrinctly resistant
Responda
-
e)all mentioned
-
d.) a+c
-
c.) vancomycin contain D-alanine-D-serine terminus
-
b.)Linezolid
-
a.) Tigecycline
Questão 55
Questão
Correct Examples
Responda
-
A class beta- lactamase = SHV-1 penicillinases found in common gram negative rods (and TEM-1)
-
B class beta - lactamase= New Delhi metallo-ß-lactamases
Questão 56
Questão
Which of the following may become resistant (acquired resistant) to macrolides
Responda
-
S.pyogenes
-
K.pneumoniae
-
S.aureus
-
Acinetobacter baumannii
-
P.aeruginosa
-
E.coli
Questão 57
Questão
Resistance to Aminoglycosides may result from:-
Responda
-
e.)all mentioned
-
d.)a+c
-
c.)increased expulsion of drug from cell
-
d.)decrease uptake of drug
-
a.)mutation of ribosomal target site
Questão 58
Questão
Resistance to this drug results from acetyltransferase which catalyse to acetylation:-this characteristics indicate
Responda
-
e.)chloramphenicol
-
d.)imipenem
-
c.)penicillin G
-
b.)ceftriaxone
-
a.)Sulfamethoxazol
Questão 59
Questão
Intrinsic resistance to tigecyycline is observed in
Responda
-
a) Morganella
-
b) Providencia Proteus and P aeruginosa
-
c) Pseudomonas
-
d) b+c
-
e) all mentioned
Questão 60
Questão
Which of the following is/are enzyme producers:
1.S.pyogenes
2.ESBL +
3.HLAR +
4.PRSP
5.MBL +
6.chlamydia trachomatis
Responda
-
1,2,3,5
-
2,5
-
2,3,5
-
only 4
-
2,3,5,6
Questão 61
Questão
Becomes resistant to aztreonam
Responda
-
e. faecalis
-
p.aeruginosa
-
acinobacter baumanii
-
s.aureus
-
s epidermidis
-
s pygones
Questão 62
Questão
1. Complete information regarding the 3 ways how bacteria can become resistant to beta-lactam antibiotics:
Responda
-
Decreased concentration of antibiotic at the cell wall from target site
-
Decreased binding of antibiotic to the PBP
-
Enzymatic modification
-
All
-
None
Questão 63
Questão
a. ESBL - [blank_start]Extended[blank_end] [blank_start]spectrum[blank_end] [blank_start]beta lactamase[blank_end]
b. VRE - [blank_start]Vancomycin[blank_end] [blank_start]resistant[blank_end] [blank_start]enterococci[blank_end]
c. KPC - [blank_start]Klebsiella[blank_end] [blank_start]Pneumoniae[blank_end] [blank_start]Carbapenemase[blank_end]
Responda
-
Extended
-
spectrum
-
beta lactamase
-
Vancomycin
-
resistant
-
enterococci
-
Klebsiella
-
Pneumoniae
-
Carbapenemase
Questão 64
Questão
5. Which of the following resistance mechanism phenotypes stem from the enzymatic modification of the drug:
Responda
-
a. PRSA
-
b. VRE
-
c. HLAR
-
d. MBL
-
e. a+c+d
Questão 65
Questão
7. Which of the following phenotype refers to MBL + P.aeruginosa:
Responda
-
a. Susceptible to carbapenems, resistant to beta lactams and its combinations with inhibitors
-
b. resistant to all beta lactams with exclusion of its combination with inhibitors
-
c. resistant to all beta lactams with possible exception of aztreonam
-
d. resistant to all beta lactams with possible exception of monobactams
-
e. c+d
Questão 66
Questão
a. A class beta lactamases: [blank_start]KPC, SHV-1, TEM-1[blank_end]
b. B class beta lactamases: [blank_start]MBL, NDM, VIM[blank_end]
Responda
-
KPC, SHV-1, TEM-1
-
MBL, NDM, VIM
Questão 67
Questão
Which of the following may become resistant to Rifampin?
Responda
-
E.Coli
-
P. Aeruginosa
-
Acinebacter Baumanii
-
S. Auereus
-
S. Pneumonia
-
M. Tuberculosis
Questão 68
Questão
10. which of the following may become resistant (acquire resistance) to rifampin:
(1) E.coli
(2) P. aeurigonase
(3) acinetobacter baumanii
(4) S .aureus
(5) K .pneumonia
(6) M. tuberculosis
Responda
-
1,2,3,5,6
-
4,3,5
-
4,5,6
-
2,3
-
4,6
Questão 69
Questão
Choose Correct Statement
Responda
-
1. Resistance to amikacin can stem from decreased uptake of drug into bacterial cell
-
2. Bacteroides fragilis is intrinsically resistant to metronidazole
-
3. Most of gram (+) bacteria is resistant to macrolides
Questão 70
Questão
Which of the follwoing resistance phenotypes refers to MBL P+Aeruginosa
Responda
-
1. Susceptible to carbapenems, resistant to B-lactams and its combinations
-
2. Resistant to all B-lactams, with exclusion of its combination with inhibitors
-
3. Resistant to all B-lactams, with possible exception of azteonem
-
4. Resistant to all B-lactams, with possible exception of macrolides
Questão 71
Questão
Complete information regarding the ways how bacteria can become resistant to aminoglycosides:
Responda
-
Target site modification
-
Decreased membrane permeability
-
Active efflux
-
: Enzymatic inactivation of antimicrobial agent
Questão 72
Questão
Choose Correct Statement
Responda
-
a/ Pseudomonas aeruginosa is intrinsically resistant to trimethoprim.
-
b/ Overexpression of efflux pumps determines the resistance to ciprofloxacin
-
c/ Polymyxins are not effective against Gram-positive bacteria due to the lack of outer membrane in these.
Questão 73
Questão
Explain the abbreviations:
PRSP: [blank_start]Penicillin resistant[blank_end] [blank_start]streptococcus pneumoniae[blank_end]
HLAR: [blank_start]High level[blank_end] [blank_start]aminoglycoside[blank_end] [blank_start]resistance[blank_end]
NDM: [blank_start]New delhi[blank_end] [blank_start]metallo-beta-lactamase[blank_end]
Responda
-
Penicillin resistant
-
streptococcus pneumoniae
-
High level
-
aminoglycoside
-
resistance
-
New delhi
-
metallo-beta-lactamase
Questão 74
Questão
Intrinsic resistance to glycopeptides is observed in:
Responda
-
a/ Lactobacillus
-
b/ Streptococcus pneumoniae
-
c/Enterococci
-
d/ E coli
-
e/ a+d
Questão 75
Questão
Which of the following resistance phenotype refers to MRSA:
Responda
-
a/ Resistant to beta-lactams with possible exception of its combinations with inhibitors.
-
b/ Resistant to all beta-lactams, susceptible to Vth generation of cephalosporins
-
c/ Resistant to narrow spectrum penicillins, resistant to macrolides and lincosamides.
-
d/ Resistant to all beta-lactams, with possible exception of monobactams.
-
e/ c+d
Questão 76
Questão
Resistance to gentamicin in Bacteroides fragilis is due to...[blank_start].lack of aerobic metabolism[blank_end]
Responda
-
.lack of aerobic metabolism
Questão 77
Questão
Which of the following may become resistant (acquire resistance) to tigecycline:
Responda
-
1. Proteus mirabilis
-
2. P. aeruginosa
-
3. Morganella morganii
-
4. E. faecalis
-
5. K. pneumoniae
-
6. Providencia retgerii
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