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412799
Apoptosis
Descrição
Year 2 Quiz sobre Apoptosis, criado por gina_evans0312 em 03-12-2013.
Sem etiquetas
cell signalling and cancer
oncogenes
year 2
Quiz por
gina_evans0312
, atualizado more than 1 year ago
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Criado por
gina_evans0312
aproximadamente 11 anos atrás
1490
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Resumo de Recurso
Questão 1
Questão
What is the main difference between apoptosis and necrosis?
Responda
In necrosis release of cell contents is controlled In apoptosis it's not
In apoptosis release of cell contents is controlled In necrosis it's not
Questão 2
Questão
What protein condenses during apoptosis
Responda
Chromatin
Actin
Myosin
Questão 3
Questão
What form are caspases usually found in?
Responda
Inactive, with their DED domain tails intact
Active, with their DED domain tails intact
Inactive, with their DED domain tails removed
Active, with their DED domain tails removed
Questão 4
Questão
What is required for caspase activation?
Responda
Addition of a DED domain tail
Removal of the DED domain tail
Questão 5
Questão
What are the roles of the 2 main caspases?
Responda
3 is the initation 8 does most damage
8 is the initiator 3 does most damage
Questão 6
Questão
Which of the following are survival/protector proteins that inhibit caspase activation?
Responda
BAX, BAD, PUMA
Bci-2, Mcl1, A1
Questão 7
Questão
What is required for ligand acitvated apoptosis?
Responda
For the receptors to contain DED domains
For the receptors to be bound to caspases
For the receptors to be expressed only in certain areas of the cell membrane
Questão 8
Questão
What protein inhibits the activation of apoptic receptors?
Responda
Flp
Flr
Fld
Questão 9
Questão
Name an apoptic receptor
Responda
Fas
Far
Fam
Questão 10
Questão
How does the receptor activate caspase 8?
Responda
By recruiting it and cleaving off the DED domain
By recruiting it and adding a DED domain
Questão 11
Questão
Name the two methods caspase 8 uses to destroy the cell
Responda
Activation of Caspase 3
Deactivation of Caspase 3
Damage to mitochondria, which releases Cyt. C
Questão 12
Questão
What does mitochondrial damage do to Casp 9?
Responda
Activates it
Deactivates it
Questão 13
Questão
What happens when essential growth factors are withdrawn from the cell?
Responda
PI3K cannot activate
PKB cannot activate
Casp 8 cannot activate
Questão 14
Questão
How does PKB inhibit apoptosis?
Responda
Releases Bad from Blc-2
Releases Blc2 from Bad
Questão 15
Questão
Identify methods which cells can use to evade apoptosis
Responda
Decreased Fas receptor expression
Inc Blc2 & decrease bax/bad expression
Loss of Casp 8
Increased Flp expression
Soluble fas to causes apoptosis in t-cells
Large amounts of Fas ligand produced to kill t-cells
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