Apoptosis

Descrição

Year 2 Quiz sobre Apoptosis, criado por gina_evans0312 em 03-12-2013.
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Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 aproximadamente 11 anos atrás
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Resumo de Recurso

Questão 1

Questão
What is the main difference between apoptosis and necrosis?
Responda
  • In necrosis release of cell contents is controlled In apoptosis it's not
  • In apoptosis release of cell contents is controlled In necrosis it's not

Questão 2

Questão
What protein condenses during apoptosis
Responda
  • Chromatin
  • Actin
  • Myosin

Questão 3

Questão
What form are caspases usually found in?
Responda
  • Inactive, with their DED domain tails intact
  • Active, with their DED domain tails intact
  • Inactive, with their DED domain tails removed
  • Active, with their DED domain tails removed

Questão 4

Questão
What is required for caspase activation?
Responda
  • Addition of a DED domain tail
  • Removal of the DED domain tail

Questão 5

Questão
What are the roles of the 2 main caspases?
Responda
  • 3 is the initation 8 does most damage
  • 8 is the initiator 3 does most damage

Questão 6

Questão
Which of the following are survival/protector proteins that inhibit caspase activation?
Responda
  • BAX, BAD, PUMA
  • Bci-2, Mcl1, A1

Questão 7

Questão
What is required for ligand acitvated apoptosis?
Responda
  • For the receptors to contain DED domains
  • For the receptors to be bound to caspases
  • For the receptors to be expressed only in certain areas of the cell membrane

Questão 8

Questão
What protein inhibits the activation of apoptic receptors?
Responda
  • Flp
  • Flr
  • Fld

Questão 9

Questão
Name an apoptic receptor
Responda
  • Fas
  • Far
  • Fam

Questão 10

Questão
How does the receptor activate caspase 8?
Responda
  • By recruiting it and cleaving off the DED domain
  • By recruiting it and adding a DED domain

Questão 11

Questão
Name the two methods caspase 8 uses to destroy the cell
Responda
  • Activation of Caspase 3
  • Deactivation of Caspase 3
  • Damage to mitochondria, which releases Cyt. C

Questão 12

Questão
What does mitochondrial damage do to Casp 9?
Responda
  • Activates it
  • Deactivates it

Questão 13

Questão
What happens when essential growth factors are withdrawn from the cell?
Responda
  • PI3K cannot activate
  • PKB cannot activate
  • Casp 8 cannot activate

Questão 14

Questão
How does PKB inhibit apoptosis?
Responda
  • Releases Bad from Blc-2
  • Releases Blc2 from Bad

Questão 15

Questão
Identify methods which cells can use to evade apoptosis
Responda
  • Decreased Fas receptor expression
  • Inc Blc2 & decrease bax/bad expression
  • Loss of Casp 8
  • Increased Flp expression
  • Soluble fas to causes apoptosis in t-cells
  • Large amounts of Fas ligand produced to kill t-cells

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