Complimentation Tests & Epistasis

Descrição

Year 2 Quiz sobre Complimentation Tests & Epistasis, criado por gina_evans0312 em 16-12-2013.
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Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 quase 11 anos atrás
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Resumo de Recurso

Questão 1

Questão
The complimentation test is used to find out if mutations are allelic or non allelic
Responda
  • True
  • False

Questão 2

Questão
In what circumstances will a Complimentation Test give a false result?
Responda
  • When the mutation is recessive
  • When the mutation is dominant
  • When the mutated gene is part of a complex
  • Where proteins form multimers

Questão 3

Questão
Genotypes M1 & M2 are bred together, and a Wild Type result is obtained- are the mutations allelic
Responda
  • No- as the presentation of a wild type phenotypes shows there is at least one dominant wild type allele for each gene
  • Yes- The two mutations on the same allele are able to compliment each other sufficiently to produce a wild type phenotype

Questão 4

Questão
If M3 and M2 are bred together and they present as M2, what does this tell us about the mutation's location?
Responda
  • They are on the same allele- there is no dominant wild type allele to mask their activity
  • They are on separate alleles, but M2 has a far greater effect than previously thought

Questão 5

Questão
According to the above table, which mutations are allelic
Responda
  • M9 & M4
  • M8 & M6
  • M2
  • All of the above

Questão 6

Questão
A Complimentation Test can be fooled if the mutant protein can form a functioning heterodimer with the wild type protein
Responda
  • True
  • False

Questão 7

Questão
One gene is said to be epistatic to another if...
Responda
  • The presence of a double mutant exhibits the phenotype of the mutant gene
  • The presence of the wild type masks the phenotype of the mutant gene
  • A genes expression causes a change in the expression of another gene further down the pathway

Questão 8

Questão
Where are epistatic genes usually found in substrate dependent pathways?
Responda
  • Upstream
  • Downstream

Questão 9

Questão
A substrate dependent pathway is a series of positive and negative regulators that act on one another of the final product
Responda
  • True
  • False

Questão 10

Questão
This image is of a Switch Regulatory Pathway
Responda
  • True
  • False

Questão 11

Questão
Why should null alleles be used for epistatic analysis (i.e how to find out the order of gene function in a pathway)
Responda
  • The masking of alleles downstream becomes obvious
  • They are easier to make than hypomorphic alleles
  • They can be used for both Substrate Dependent and Switch pathways

Questão 12

Questão
How do we identify that the pathway effected by the (epistatic) mutation is a Switch Regulatory pathway?
Responda
  • If the mutation prevents the production of the final product
  • If the phenotype of a double mutant is different to the phenotype of either single mutant

Questão 13

Questão
The Rif1 & Rif2 strains are both causes lengthened telomeres, as shown in the diagram. Based on the Rif1/Rif2 double mutation, which of the two availible pathways (shown) is likely to be the one used?
Responda
  • Pathway A
  • Pathway B

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